B cells help cross-priming antiviral CD8⁺ T cells

Upasani V, Rodenhuis-Zybert I, Cantaert T. Antibody-independent functions of B cells during viral infections. PLoS Pathog. 2021;17:e1009708.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu X, Waisman A. B cells maintainthe homeostasis of splenic marginal zone antigen-presenting cells topromote the anti-viral CD8+ T-cell response. Cell Mol Immunol. 2026;23:383–99.

Joffre OP, Segura E, Savina A, Amigorena S. Cross-presentation by dendritic cells. Nat Rev Immunol. 2012;12:557–69.

Article  PubMed  CAS  Google Scholar 

Mihalic A, Zeleznjak J, Lisnic B, Jonjic S, Juranic Lisnic V, Brizic I. Immune surveillance of cytomegalovirus in tissues. Cell Mol Immunol. 2024;21:959–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

A-Gonzalez N, Castrillo A. Origin and specialization of splenic macrophages. Cell Immunol. 2018;330:151–8.

Article  PubMed  CAS  Google Scholar 

Hsu KM, Pratt JR, Akers WJ, Achilefu SI, Yokoyama WM. Murine cytomegalovirus displays selective infection of cells within hours after systemic administration. J Gen Virol. 2009;90:33–43.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mauvais FX, Hamel Y, Silvin A, Mulder K, Hildner K, Akyol R, et al. Metallophilic marginal zone macrophages cross-prime CD8(+) T-cell-mediated protective immunity against blood-borne tumors. Immunity. 2025;58:843–60.e20.

Article  PubMed  CAS  Google Scholar 

Backer R, Schwandt T, Greuter M, Oosting M, Jungerkes F, Tuting T, et al. Effective collaboration between marginal metallophilic macrophages and CD8+ dendritic cells in the generation of cytotoxic T cells. Proc Natl Acad Sci USA. 2010;107:216–21.

Article  PubMed  CAS  Google Scholar 

van Dinther D, Veninga H, Iborra S, Borg EGF, Hoogterp L, Olesek K, et al. Functional CD169 on macrophages mediates interaction with dendritic cells for CD8(+) T-cell cross-priming. Cell Rep. 2018;22:1484–95.

Article  PubMed  Google Scholar 

Schneider K, Loewendorf A, De Trez C, Fulton J, Rhode A, Shumway H, et al. Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus. Cell Host Microbe. 2008;3:67–76.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Comments (0)

No login
gif