Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

PubMed  Google Scholar 

Vetter MH, Smith B, Benedict J, Hade EM, Bixel K, Copeland LJ, et al. Preoperative predictors of endometrial cancer at time of hysterectomy for endometrial intraepithelial neoplasia or complex atypical hyperplasia. Am J Obstet Gynecol. 2020;222(1):60–e1.

Article  Google Scholar 

Clarke MA, Long BJ, Morillo ADM, Arbyn M, Bakkum-Gamez JN, Wentzensen N. Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern Med. 2018;178(9):1210–22.

Article  PubMed  PubMed Central  Google Scholar 

Matteson KA, Robison K, Jacoby VL. Opportunities for early detection of endometrial cancer in women with postmenopausal bleeding. JAMA Intern Med. 2018;178(9):1222–3.

Article  PubMed  Google Scholar 

Pennant M, Mehta R, Moody P, Hackett G, Prentice A, Sharp S, et al. Premenopausal abnormal uterine bleeding and risk of endometrial cancer. BJOG: An International Journal of Obstetrics & Gynaecology. 2017;124(3):404–11.

Article  CAS  Google Scholar 

Raffone A, Travaglino A, Saccone G, D’Alessandro P, Arduino B, Mascolo M, et al. Diabetes mellitus is associated with occult cancer in endometrial hyperplasia. Pathol Oncol Res. 2020;26:1377–84.

Article  PubMed  Google Scholar 

National Cancer Institute Surveillance. Epidemiology and End Results Program (SEER). Cancer Stat facts: uterine cancer. 2018.

Alblas M, Velt KB, Pashayan N, Widschwendter M, Steyerberg EW, Vergouwe Y. Prediction models for endometrial cancer for the general population or symptomatic women: a systematic review. Crit Rev Oncol Hematol. 2018;126:92–9.

Article  PubMed  Google Scholar 

Szubert S, Szpurek D, Wójtowicz A, Żywica P, Stukan M, Sajdak S, et al. Performance of selected models for predicting malignancy in ovarian tumors in relation to the degree of diagnostic uncertainty by subjective assessment with ultrasound. J Ultrasound Med. 2020;39(5):939–47.

Article  PubMed  Google Scholar 

Scioscia M, Noventa M, Laganà AS. Abnormal uterine bleeding and the risk of endometrial cancer: can subendometrial vascular ultrasound be of help to discriminate cancer from adenomyosis? Am J Obstet Gynecol. 2020;223(4):605–6.

Article  PubMed  Google Scholar 

Bagepalli Srinivas S, Kubakaddi SS, Polisetti S, Amber S, Guruvare S, Vaman Pai M. A novel risk-scoring model for prediction of premalignant and malignant lesions of uterine endometrium among symptomatic premenopausal women. Int J Womens Health. 2020;12:883–91.

Article  PubMed  PubMed Central  Google Scholar 

Rotterdam E. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25.

Article  Google Scholar 

Giannella L, Cerami LB, Setti T, Bergamini E, Boselli F. Prediction of endometrial hyperplasia and cancer among premenopausal women with abnormal uterine bleeding. Biomed Res Int. 2019;2019:8598152.

Article  PubMed  PubMed Central  Google Scholar 

Sweet MG, Schmidt-Dalton TA, Weiss PM, Madsen KP. Evaluation and management of abnormal uterine bleeding in premenopausal women. Am Fam Physician. 2012;85(1):35–43.

PubMed  Google Scholar 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–386.

Article  CAS  PubMed  Google Scholar 

Aune D, Rosenblatt DN, Chan D, Vingeliene S, Abar L, Vieira A, et al. Anthropometric factors and endometrial cancer risk: a systematic review and dose–response meta-analysis of prospective studies. Ann Oncol. 2015;26(8):1635–48.

Article  CAS  PubMed  Google Scholar 

Wise MR, Gill P, Lensen S, Thompson JM, Farquhar CM. Body mass index trumps age in decision for endometrial biopsy: cohort study of symptomatic premenopausal women. Am J Obstet Gynecol. 2016;215(5):598–e1.

Article  Google Scholar 

Guraslan H, Dogan K, Kaya C, Senturk MB, Guraslan B, Helvacioglu C, et al. Could body mass index be an indicator for endometrial biopsy in premenopausal women with heavy menstrual bleeding? Arch Gynecol Obstet. 2016;294:395–402.

Article  PubMed  Google Scholar 

Wang X, Glubb DM, O’Mara TA. Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study. Nutrients. 2023;15(3).

Google Scholar 

Gong TT, Wang YL, Ma XX. Age at menarche and endometrial cancer risk: a dose-response meta-analysis of prospective studies. Sci Rep. 2015;5(1):14051.

Article  PubMed  PubMed Central  Google Scholar 

Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, et al. Endometrial hyperplasia as a risk factor of endometrial cancer. Arch Gynecol Obstet. 2022;306(2):407–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang HP, Murphy KR, Pfeiffer RM, George N, Garcia-Closas M, Lissowska J, et al. Lifetime number of ovulatory cycles and risks of ovarian and endometrial cancer among postmenopausal women. Am J Epidemiol. 2016;183(9):800–14.

Article  PubMed  PubMed Central  Google Scholar 

Stachowicz N, Smoleń A, Ciebiera M, Łoziński T, Poziemski P, Borowski D, et al. Risk assessment of endometrial hyperplasia or endometrial cancer with simplified ultrasound-based scoring systems. Diagnostics. 2021;11(3):442.

Article  PubMed  PubMed Central  Google Scholar 

Wynants L, Verbakel JYJ, Valentin L, De Cock B, Pascual MA, Leone FP, et al. The risk of endometrial malignancy and other endometrial pathology in women with abnormal uterine bleeding: an ultrasound-based model development study by the IETA group. Gynecol Obstet Invest. 2022;87(1):54–61.

Article  CAS  PubMed  Google Scholar 

Kim MJ, Kim JJ, Kim SM. Endometrial evaluation with transvaginal ultrasonography for the screening of endometrial hyperplasia or cancer in premenopausal and perimenopausal women. Obstet Gynecol Sci. 2016;59(3):192.

Article  PubMed  PubMed Central  Google Scholar 

den Van Bosch T, Ameye L, Van Schoubroeck D, Bourne T, Timmerman D. Intra-cavitary uterine pathology in women with abnormal uterine bleeding: a prospective study of 1220 women. Facts Views Vis ObGyn. 2015;7(1):17.

Google Scholar 

Alcázar JL, Bonilla L, Marucco J, Padilla AI, Chacón E, Manzour N, et al. Risk of endometrial cancer and endometrial hyperplasia with atypia in asymptomatic postmenopausal women with endometrial thickness ≥ 11 mm: a systematic review and meta-analysis. J Clin Ultrasound. 2018;46(9):565–70.

Article  PubMed  Google Scholar 

Ruan H, Chen S, Li J, Ma L, Luo J, Huang Y, et al. Development and validation of a nomogram prediction model for endometrial malignancy in patients with abnormal uterine bleeding. Yonsei Med J. 2023;64(3):197.

Article  PubMed  PubMed Central  Google Scholar