Association between resting heart rate and clinical outcomes in heart failure with preserved ejection fraction: age stratified insights from the KUNIUMI Registry

Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, Yaku H, Akiyama E, Ando M, Izumi C, Ide T (2025) JCS/JHFS 2025 guideline on diagnosis and treatment of heart failure. Circ J 89(8):1278–1444

Article  PubMed  Google Scholar 

Kitao T, Hikoso S, Tamaki S, Seo M, Yano M, Hayashi T, Nakagawa A, Nakagawa Y, Sotomi Y, Nakatani D, Yamada T, Yasumura Y, Sakata Y, Investigators OC-HF (2025) Post-discharge changes in nutritional status predict prognosis in patients with acute decompensated HFpEF from the PURSUIT-HFpEF Registry. Heart Vessels 40:577–591

PubMed  Google Scholar 

Nishino M, Egami Y, Sugino A, Kobayashi N, Abe M, Ohsuga M, Nohara H, Kawanami S, Ukita K, Kawamura A, Yasumoto K, Okamoto N, Matsunaga-Lee Y, Yano M, Yamada M, Yasumura Y, Seo M, Hayashi T, Nakagawa A, Nakagawa Y, Tamaki S, Okada K, Sotomi Y, Nakatani D, Hikoso S, Sakata Y, Osaka CardioVascular Conference -Heart Failure I (2025) Characteristics of comparatively young heart failure with preserved ejection fraction: PurSuit-HFpEF registry. Heart Vessels 40:863–873

Article  PubMed  Google Scholar 

Gazewood JD, Turner PL (2017) Heart Failure with Preserved Ejection Fraction: Diagnosis and Management. Am Fam Physician 96:582–588

PubMed  Google Scholar 

Jouven X, Empana JP, Schwartz PJ, Desnos M, Courbon D, Ducimetiere P (2005) Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352:1951–1958

Article  CAS  PubMed  Google Scholar 

Bohm M, Swedberg K, Komajda M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L, Investigators S (2010) Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet 376:886–894

Article  PubMed  Google Scholar 

Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L, Investigators S (2010) Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 376:875–885

Article  CAS  PubMed  Google Scholar 

Koruth JS, Lala A, Pinney S, Reddy VY, Dukkipati SR (2017) The Clinical Use of Ivabradine. J Am Coll Cardiol 70:1777–1784

Article  PubMed  Google Scholar 

Bohm M, Perez AC, Jhund PS, Reil JC, Komajda M, Zile MR, McKelvie RS, Anand IS, Massie BM, Carson PE, McMurray JJ, Committees IP, Investigators (2014) Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve). Eur J Heart Fail 16:778–787

Article  PubMed  Google Scholar 

Komajda M, Isnard R, Cohen-Solal A, Metra M, Pieske B, Ponikowski P, Voors AA, Dominjon F, Henon-Goburdhun C, Pannaux M, Bohm M, prEserve DFI (2017) Effect of ivabradine in patients with heart failure with preserved ejection fraction: the EDIFY randomized placebo-controlled trial. Eur J Heart Fail 19:1495–1503

Article  CAS  PubMed  Google Scholar 

Conceicao LSR, Gois C, Fernandes RES, Souza DS, Junior MBG, Carvalho VO (2021) Effect of ivabradine on exercise capacity in individuals with heart failure with preserved ejection fraction. Heart Fail Rev 26:157–163

Article  CAS  PubMed  Google Scholar 

Fujimoto W, Toh R, Takegami M, Imanishi J, Hamana T, Odajima S, Takemoto M, Kuroda K, Hatani Y, Yamashita S, Iwasaki M, Inoue T, Okamoto H, Todoroki T, Okuda M, Hayashi T, Konishi A, Tanaka H, Shinohara M, Nagao M, Murata S, Ogata S, Nishimura K, Hirata KI (2023) Aetiology of chronic heart failure in patients from a super-aged society: the KUNIUMI registry chronic cohort. ESC Heart Fail 10:100–110

Article  PubMed  Google Scholar 

Odajima S, Fujimoto W, Takegami M, Nishimura K, Iwasaki M, Okuda M, Konishi A, Shinohara M, Nagao M, Toh R, Hirata KI, Tanaka H (2024) BEEAF(2) Score: A New Risk Stratification Score for Patients With Stage B Heart Failure From the KUNIUMI Registry Chronic Cohort. J Am Heart Assoc 13:e034793

Article  PubMed  PubMed Central  Google Scholar 

Shiba N, Nochioka K, Miura M, Kohno H, Shimokawa H, Investigators C- (2011) Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan–first report from the CHART-2 study. Circ J 75:823–833

Article  PubMed  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1–39 e14

Article  PubMed  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 16:233–270

Article  PubMed  Google Scholar 

Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J, Lang RM, Little SH, Shah DJ, Shernan S, Thavendiranathan P, Thomas JD, Weissman NJ (2017) Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr 30:303–371

Article  PubMed  Google Scholar 

Yamamoto K, Origasa H, Hori M, Investigators JD (2013) Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF). Eur J Heart Fail 15:110–118

Article  CAS  PubMed  Google Scholar 

Tanaka H, Yamauchi Y, Imanishi J, Hatani Y, Odajima S, Okamoto H, Hayashi T, Hirata KI (2022) Effect of Ivabradine on Left Ventricular Diastolic Function of Patients With Preserved Ejection Fraction - Results of the IVA-PEF Study. Circ Rep 4:499–504

Article  PubMed  PubMed Central  Google Scholar 

Noiri J, Fujimoto W, Takemoto M, Kuroda K, Yamashita S, Imanishi J, Iwasaki M, Todoroki T, Okuda M, Nagao M, Konishi A, Shinohara M, Toh R, Nishimura K, Tanaka H (2025) Population Gap for Chronic Heart Failure Patients Between Randomized Controlled Trials and Japan’s Super-Aged Society. Circ Rep 7:331–340

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif