Galea I, Bechmann I, Perry VH. What is immune privilege (not)? Trends Immunol. 2007;28(1):12–8. https://doi.org/10.1016/j.it.2006.11.004.

Article  CAS  PubMed  Google Scholar 

Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci. 2014;15(5):300–12. https://doi.org/10.1038/nrn3722.

Article  CAS  PubMed  Google Scholar 

Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46–56. https://doi.org/10.1038/nrn2297.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsokos GC. Systemic lupus erythematosus. N Engl J Med. 2011;365(22):2110–21. https://doi.org/10.1056/NEJMra1100359.

Article  CAS  PubMed  Google Scholar 

Rönnblom L, Eloranta ML, Alm GV. The type I interferon system in systemic lupus erythematosus. Arthritis Rheum. 2006;54(2):408–20. https://doi.org/10.1002/art.21571.

Article  CAS  PubMed  Google Scholar 

Jeltsch-David H, Muller S. Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Nat Rev Neurol. 2014;10(10):579–96. https://doi.org/10.1038/nrneurol.2014.148.

Article  CAS  PubMed  Google Scholar 

Unterman A, Nolte JE, Boaz M, Abady M, Shoenfeld Y, Zandman-Goddard G. Neuropsychiatric syndromes in systemic lupus erythematosus: a meta-analysis. Semin Arthritis Rheum. 2011;41(1):1–11. https://doi.org/10.1016/j.semarthrit.2010.08.001.

Article  PubMed  Google Scholar 

Zirkzee EJ, Huizinga TW, Bollen EL, et al. Mortality in neuropsychiatric systemic lupus erythematosus (NPSLE). Lupus. 2014;23(1):31–8. https://doi.org/10.1177/0961203313512540.

Article  CAS  PubMed  Google Scholar 

Bertsias GK, Ioannidis JP, Aringer M, et al. EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs. Ann Rheum Dis. 2010;69(12):2074–82. https://doi.org/10.1136/ard.2010.130476.

Article  CAS  PubMed  Google Scholar 

Barile-Fabris L, Ariza-Andraca R, Olguín-Ortega L, et al. Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus. Ann Rheum Dis. 2005;64(4):620–5. https://doi.org/10.1136/ard.2004.025528.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwartz N, Stock AD, Putterman C. Neuropsychiatric lupus: new mechanistic insights and future treatment directions. Nat Rev Rheumatol. 2019;15(3):137–52. https://doi.org/10.1038/s41584-018-0156-8.

Article  PubMed  PubMed Central  Google Scholar 

Kaplan MJ. Role of neutrophils in systemic autoimmune diseases. Arthritis Res Ther. 2013;15(5):219. https://doi.org/10.1186/ar4325.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hakkim A, Fürnrohr BG, Amann K, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A. 2010;107(21):9813–8. https://doi.org/10.1073/pnas.0909927107.

Article  PubMed  PubMed Central  Google Scholar 

Gaipl US, Munoz LE, Grossmayer G, et al. Clearance deficiency and systemic lupus erythematosus (SLE). J Autoimmun. 2007;28(2–3):114–21. https://doi.org/10.1016/j.jaut.2007.02.005.

Article  PubMed  Google Scholar 

Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol. 2006;6(11):823–35. https://doi.org/10.1038/nri1957.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006;25(3):417–28. https://doi.org/10.1016/j.immuni.2006.07.013.

Article  CAS  PubMed  Google Scholar 

Ablasser A, Chen ZJ. cGAS in action: Expanding roles in immunity and inflammation. Science. 2019. https://doi.org/10.1126/science.aat8657.

Article  PubMed  Google Scholar 

Siegal FP, Kadowaki N, Shodell M, et al. The nature of the principal type 1 interferon-producing cells in human blood. Science. 1999;284(5421):1835–7. https://doi.org/10.1126/science.284.5421.1835.

Article  CAS  PubMed  Google Scholar 

Baechler EC, Batliwalla FM, Karypis G, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A. 2003;100(5):2610–5. https://doi.org/10.1073/pnas.0337679100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crow MK. Type I interferon in the pathogenesis of lupus. J Immunol. 2014;192(12):5459–68. https://doi.org/10.4049/jimmunol.1002795.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell IL, Krucker T, Steffensen S, et al. Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha. Brain Res. 1999;835(1):46–61. https://doi.org/10.1016/s0006-8993(99)01328-1.

Article  CAS  PubMed  Google Scholar 

Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Structure and function of the blood–brain barrier. Neurobiol Dis. 2010;37(1):13–25. https://doi.org/10.1016/j.nbd.2009.07.030.

Article  CAS  PubMed  Google Scholar 

Daneman R, Prat A. The blood–brain barrier. Cold Spring Harb Perspect Biol. 2015;7(1):a020412. https://doi.org/10.1101/cshperspect.a020412.

Article  PubMed  PubMed Central  Google Scholar 

Abbott NJ, Rönnbäck L, Hansson E. Astrocyte–endothelial interactions at the blood–brain barrier. Nat Rev Neurosci. 2006;7(1):41–53. https://doi.org/10.1038/nrn1824.

Article  CAS  PubMed  Google Scholar 

Iadecola C. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron. 2017;96(1):17–42. https://doi.org/10.1016/j.neuron.2017.07.030.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varatharaj A, Galea I. The blood–brain barrier in systemic inflammation. Brain Behav Immun. 2017;60:1–12. https://doi.org/10.1016/j.bbi.2016.03.010.

Article  CAS  PubMed  Google Scholar 

Luissint AC, Artus C, Glacial F, Ganeshamoorthy K, Couraud PO. Tight junctions at the blood–brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS. 2012;9(1):23. https://doi.org/10.1186/2045-8118-9-23.

Article  PubMed  PubMed Central  Google Scholar 

Stamatovic SM, Keep RF, Andjelkovic AV. Brain endothelial cell–cell junctions: how to “open” the blood–brain barrier. Curr Neuropharmacol. 2008;6(3):179–92. https://doi.org/10.2174/157015908785777210.

Article  CAS  PubMed