Khorasani MMY, Hassanshahi G, Brodzikowska A, Khorramdelazad H. Role(s) of cytokines in pulpitis: latest evidence and therapeutic approaches. Cytokine. 2020;126:154896. https://doi.org/10.1016/j.cyto.2019.154896.

Article  CAS  PubMed  Google Scholar 

Yu L, Zeng L, Zhang Z, et al. Cannabidiol rescues TNF-α-inhibited proliferation, migration, and osteogenic/odontogenic differentiation of dental pulp stem cells. Biomolecules. 2023;13(1):118. https://doi.org/10.3390/biom13010118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pohl S, Akamp T, Smeda M, et al. Understanding dental pulp inflammation: from signaling to structure. Front Immunol. 2024;15:1474466. https://doi.org/10.3389/fimmu.2024.1474466.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soares CLR, Wilairatana P, Silva LR, et al. Biochemical aspects of the inflammatory process: a narrative review. Biomed Pharmacother. 2023;168:115764. https://doi.org/10.1016/j.biopha.2023.115764.

Article  CAS  PubMed  Google Scholar 

Turner MD, Nedjai B, Hurst T, Pennington DJ. Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2014;1843(11):2563–82. https://doi.org/10.1016/j.bbamcr.2014.05.014.

Article  CAS  PubMed  Google Scholar 

Goldberg M, Njeh A, Uzunoglu E. Is pulp inflammation a prerequisite for pulp healing and regeneration? Mediators Inflamm. 2015;2015:347649. https://doi.org/10.1155/2015/347649.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galler KM, Weber M, Korkmaz Y, Widbiller M, Feuerer M. Inflammatory response mechanisms of the dentine–pulp complex and the periapical tissues. Int J Mol Sci. 2021;22(3):1480. https://doi.org/10.3390/ijms22031480.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li P, Ou Q, Shi S, Shao C. Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications. Cell Mol Immunol. 2023;20(6):558–69. https://doi.org/10.1038/s41423-023-00998-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tong Z, Wu J, Gong Q, Yuan Y, Wang S, Jiang W. Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA-sequencing. J Adv Res. 2024. https://doi.org/10.1016/j.jare.2024.12.018.

Article  PubMed  PubMed Central  Google Scholar 

Kavakebian F, Rezapour A, Seyedebrahimi R, et al. Intrinsic and extrinsic modulators of human dental pulp stem cells: advancing strategies for tissue engineering applications. Mol Biol Rep. 2025;52(1):190. https://doi.org/10.1007/s11033-025-10281-0.

Article  CAS  PubMed  Google Scholar 

Song M, Yu B, Kim S, et al. Clinical and molecular perspectives of reparative dentin formation. Dent Clin North Am. 2017;61(1):93–110. https://doi.org/10.1016/j.cden.2016.08.008.

Article  PubMed  PubMed Central  Google Scholar 

Qin Z, Fang Z, Zhao L, Chen J, Li Y, Liu G. High dose of TNF-α suppressed osteogenic differentiation of human dental pulp stem cells by activating the Wnt/β-catenin signaling. J Mol Histol. 2015;46(4–5):409–20. https://doi.org/10.1007/s10735-015-9630-7.

Article  CAS  PubMed  Google Scholar 

Ayadilord M, Nasseri S, Emadian Razavi F, Saharkhiz M, Rostami Z, Naseri M. Immunomodulatory effects of phytosomal curcumin on related-micro RNAs, CD200 expression and inflammatory pathways in dental pulp stem cells. Cell Biochem Funct. 2021;39(7):886–95. https://doi.org/10.1002/cbf.3659.

Article  CAS  PubMed  Google Scholar 

Chen J, Xu H, Xia K, Cheng S, Zhang Q. Resolvin E1 accelerates pulp repair by regulating inflammation and stimulating dentin regeneration in dental pulp stem cells. Stem Cell Res Ther. 2021;12(1):75. https://doi.org/10.1186/s13287-021-02141-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang Z, Zhou W, Tian X, et al. A protective role of canonical Wnt/β-catenin pathway in pathogenic bacteria-induced inflammatory responses. Mediators Inflamm. 2024;2024:8869510. https://doi.org/10.1155/2024/8869510.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang R, Huang S, Wang L, Peng B. Histochemical localization of Dickkopf-1 in induced rat periapical lesions. J Endod. 2014;40(9):1394–9. https://doi.org/10.1016/j.joen.2014.03.023.

Article  PubMed  Google Scholar 

Liu J, Ren X, Zhang M, Lei Y, Chen Y, He H. Roles of Wnt3a and Dkk1 in experimental periodontitis. J Dent Sci. 2017;12(3):220–5. https://doi.org/10.1016/j.jds.2016.11.006.

Article  PubMed  PubMed Central  Google Scholar 

Napimoga MH, Nametala C, da Silva FL, et al. Involvement of the Wnt-β-catenin signalling antagonists, sclerostin and dickkopf-related protein 1, in chronic periodontitis. J Clin Periodontol. 2014;41(6):550–7. https://doi.org/10.1111/jcpe.12245.

Article  CAS  PubMed  Google Scholar 

Duspara K, Sikora R, Petrovic A, et al. Changes in Dickkopf-1, but not sclerostin, in gingival crevicular fluid are associated with peroral statin treatment in patients with periodontitis. Medicina (Kaunas). 2024. https://doi.org/10.3390/medicina60030508.

Article  PubMed  PubMed Central  Google Scholar 

Xu F-F, Jiang B-Z. Effect of DKK1 on the biological behaviors of dental pulp cells exposed to lipopolysaccharide. Shanghai J Stomatol. 2021;30(4):355. https://doi.org/10.19439/j.sjos.2021.04.004.

Article  CAS  Google Scholar 

Brodzikowska A, Ciechanowska M, Kopka M, Stachura A, Włodarski PK. Role of lipopolysaccharide, derived from various bacterial species, in pulpitis—a systematic review. Biomolecules. 2022;12(1):138. https://doi.org/10.3390/biom12010138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzec‐Interián JA, González‐Padilla D, Góngora‐Castillo EB. Bioinformatics perspectives on transcriptomics: a comprehensive review of bulk and single‐cell RNA-sequencing analyses. Quant Biol. 2025;13(2):e78. https://doi.org/10.1002/qub2.78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanches PHG, de Melo NC, Porcari AM, de Carvalho LM. Integrating molecular perspectives: strategies for comprehensive multi-omics integrative data analysis and machine learning applications in transcriptomics, proteomics, and metabolomics. Biology. 2024;13(11):848. https://doi.org/10.3390/biology13110848.

Article  PubMed  PubMed Central  Google Scholar 

Huang P, Wang F, Wang X, Meng X, Qiao W, Meng L. RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells. Int Endod J. 2023;56(1):39–52. https://doi.org/10.1111/iej.13842.

Article  PubMed  Google Scholar 

Nam OH, Kim JH, Kang SW, et al. Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammation in human dental pulp cells via the PI3K/Akt, NF-κB, and MAPK signalling pathways. Int Endod J. 2024;57(6):759–68. https://doi.org/10.1111/iej.14058.

Article  PubMed  Google Scholar 

Liu M, Chen L, Wu J, Lin Z, Huang S. Long noncoding RNA MEG3 expressed in human dental pulp regulates LPS-induced inflammation and odontogenic differentiation in pulpitis. Exp Cell Res. 2021;400(2):112495. https://doi.org/10.1016/j.yexcr.2021.112495.

Article  CAS  PubMed  Google Scholar 

Sasaki JI, Zhang Z, Oh M, et al. VE-cadherin and anastomosis of blood vessels formed by dental stem cells. J Dent Res. 2020;99(4):437–45. https://doi.org/10.1177/0022034520902458.

Article  CAS  PubMed