QiangGuYin-containing serum improves osteogenic differentiation via regulating osteoclast-derived exosomal miR-27b-3p

Cheng F, Yang F, Wang Y, Zhou J, Qian H, Yan Y (2023) Mesenchymal stem cell-derived exosomal miR-27b-3p alleviates liver fibrosis via downregulating YAP/LOXL2 pathway. J Nanobiotechnol 21(1):195

Article  CAS  Google Scholar 

Cui L, Liu Q, Li Z, Li X, Shen G, Fang Y et al (2021) Effect of Qiangguyin on inflammatory cytokines and OPG and RANKL and bone mineral density in serum in senile female patients with osteoporosis. Chin J Trad Med Traumatol Orthop 29(03):30–35

Google Scholar 

Devotta A, Hong CS, Saint-Jeannet JP. Dkk2 promotes neural crest specification by activating Wnt/beta-catenin signaling in a GSK3beta independent manner. Elife. 2018;7.

Feng X, McDonald JM (2011) Disorders of bone remodeling. Annu Rev Pathol 6:121–145

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu S, Rong Y, Deng Y, Li L, Hu J, Yuan X et al (2023) miR-27b-3p inhibits estrogen secretion of goose granulosa cells by targeting CYP1B1 through the AMPK signaling pathway. Poult Sci 102(4):102546

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Zhang J, Zhu Y, Zhao R, Xie Z, Qu X et al (2026) BMP9 alleviates iron accumulation-induced osteoporosis via the USP10/FOXO1/GPX4 axis. J Adv Res 79:953–972

Article  CAS  PubMed  Google Scholar 

Li D, Liu J, Guo B, Liang C, Dang L, Lu C et al (2016) Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun 7:10872

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Chen X, Lu L, Yu X (2020a) The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis. Cytokine Growth Factor Rev 52:88–98

Article  PubMed  Google Scholar 

Li ZH, Hu H, Zhang XY, Liu GD, Ran B, Zhang PG et al (2020b) MiR-291a-3p regulates the BMSCs differentiation via targeting DKK1 in dexamethasone-induced osteoporosis. Kaohsiung J Med Sci 36(1):35–42

Article  CAS  PubMed  Google Scholar 

Li J, Peng XL, Cheng XY, Yang JJ, Cui C, Liu JH (2025) Pinocembrin alleviates postoperative cognitive dysfunction in aged mice by modulating miR-384-5p/FZD1 axis to activate the Wnt/beta-catenin pathway. Mol Neurobiol 62(11):13975–13988

Article  CAS  PubMed  Google Scholar 

Liu J, Wang B, Chen H, Yu X, Cao X, Zhang H (2024) Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis. Biomed Pharmacother 178:117231

Article  CAS  PubMed  Google Scholar 

Ma S, Li S, Zhang Y, Nie J, Cao J, Li A et al (2023) BMSC-derived exosomal CircHIPK3 promotes osteogenic differentiation of MC3T3-E1 cells via mitophagy. Int J Mol Sci. https://doi.org/10.3390/ijms24032785

Article  PubMed  PubMed Central  Google Scholar 

Ma YR, Gao W, Wang HQ, Zhao PS, Zhang YX, Wei FH et al (2024) EGF-driven EGFR/miR-27b-3p/FOXO1 promotes rat FSH synthesis and secretion. FASEB J 38(4):e23469

Article  CAS  PubMed  Google Scholar 

Manochantr S, Meesuk L, Chadee N, Suwanprateeb J, Tantrawatpan C, Kheolamai P (2024) Improvement of osteogenic differentiation potential of placenta-derived mesenchymal stem cells by Metformin via AMPK pathway activation. Stem Cell Res Ther 15(1):417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng S, Zhang X, Yu Y, Tong M, Yuan Y, Cao Y et al (2024) New-QiangGuYin-containing serum inhibits osteoclast-derived exosome secretion and down-regulates Notum to promote osteoblast differentiation. Adv Biol Weinh. https://doi.org/10.1002/adbi.202400166

Article  PubMed  Google Scholar 

Mosa MH, Michels BE, Menche C, Nicolas AM, Darvishi T, Greten FR et al (2020) A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer. Cancer Res 80(24):5569–5582

Article  CAS  PubMed  Google Scholar 

Nguyen HTT, Ngo QV, Le DTT, Nguyen MTH, Nguyen PTM (2022) Beta-sitosterol from Clinacanthus nutans Lindau enhances osteoblastogenic activity via upregulation of differentiation related genes and proteins. Biosci Biotechnol Biochem 86(12):1615–1622

Article  PubMed  Google Scholar 

Pan L, Zhang C, Zhang H, Ke T, Bian M, Yang Y et al (2023) Osteoclast-derived exosomal miR-5134-5p interferes with alveolar bone homeostasis by targeting the JAK2/STAT3 axis. Int J Nanomed 18:3727–3744

Article  CAS  Google Scholar 

Ren L, Zeng F, Deng J, Bai Y, Chen K, Chen L et al (2022) Inflammatory osteoclasts-derived exosomes promote bone formation by selectively transferring lncRNA LIOCE into osteoblasts to interact with and stabilize Osterix. FASEB J 36(2):e22115

Article  CAS  PubMed  Google Scholar 

Shi Z, Liu Z, Chen W, Mao Y, Zhang J, Li C et al (2017) A multicenter clinical study of complex therapy of traditional Chinese medicine for prevention and treatment of postmenopausal osteopenia. J Trad Chin Orthop Trauma 29(04):1–7

Google Scholar 

Sun JG, Zhou H, Huang H, Yuan YF, Wang S, He CJ et al (2022) Randomized controlled study of Yiqi Wenshen formula combined with zoledronic acid in the treatment of primary type I osteoporosis. Chin J Integr Trad West Med 42(06):685–692

CAS  Google Scholar 

Tang B, Yuan Y, Wang S, Li S, Kang S, He C et al (2022) The Chinese herbal formula QiangGuYin regulates the Wnt/β-catenin pathway in osteoblasts by intervening in the expression of miRNAs derived from osteoclast exosomes. Pharmacol Res Mod Chin Med. https://doi.org/10.1016/j.prmcm.2022.100087

Article  Google Scholar 

Wang T, Xu Z (2010) miR-27 promotes osteoblast differentiation by modulating Wnt signaling. Biochem Biophys Res Commun 402(2):186–189

Article  CAS  PubMed  Google Scholar 

Wang N, Wang L, Yang J, Wang Z, Cheng L (2021) Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway. Phytother Res 35(5):2639–2650

Article  CAS  PubMed  Google Scholar 

Wang Y, Zhou X, Wang D (2022) Mesenchymal stem cell-derived extracellular vesicles inhibit osteoporosis via MicroRNA-27a-induced inhibition of DKK2-mediated Wnt/beta-catenin pathway. Inflammation 45(2):780–799

Article  CAS  PubMed  Google Scholar 

Wen J, Bao Z, Li L, Liu Y, Wei B, Ye X et al (2023) Qiangguyin inhibited fat accumulation in OVX mice through the p38 MAPK signaling pathway to achieve anti-osteoporosis effects. Biomed Pharmacother 158:114122

Article  CAS  PubMed  Google Scholar 

Yang JX, Xie P, Li YS, Wen T, Yang XC (2020) Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2. Cell Signal 70:109504

Article  CAS  PubMed  Google Scholar 

Yuan YF, Wang S, Zhou H, Tang BB, Liu Y, Huang H et al (2022a) Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/beta-catenin signaling pathway and analysis of active ingredients by molecular docking. Front Pharmacol 13:994995

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan Y, Sun J, Zhou H, Wang S, He C, Chen T et al (2022b) The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1. Aging (Albany NY) 14(2):892–906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou B, Peng K, Wang G, Chen W, Liu P, Chen F et al (2020) miR‑483‑3p promotes the osteogenesis of human osteoblasts by targeting Dikkopf 2 (DKK2) and the Wnt signaling pathway. Int J Mol Med 46(4):1571–1581

CAS  PubMed  PubMed Central  Google Scholar 

Zhu H, Cai C, Yu Y, Zhou Y, Yang S, Hu Y et al (2024) Quercetin-loaded bioglass injectable hydrogel promotes m6A alteration of Per1 to alleviate oxidative stress for periodontal bone defects. Adv Sci (Weinh) 11(29):e2403412

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif