Achar RAN, Silva TC, Achar E, Martines RB, Machado JLM (2014) Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats. Acta Cir Bras 29:125–131. https://doi.org/10.1590/s0102-86502014000200009

Article  PubMed  Google Scholar 

Alsarayreh AZ, Khleifat KM, Al-Dalain SEM, Al-Saraireh YM, Al Qaisi YT, Alfarrayeh II, Al-Qaraleh SY (2023) Globularia arabica methanolic leaf extract has higher efficacy on burn wound healing in diabetic rats compared to Malva sylvestris methanolic leaf extract. J Burn Care Res 44(3):563–572. https://doi.org/10.1093/jbcr/irac089

Article  PubMed  Google Scholar 

Arican M, Hatipoglu F, Uyaroglu A, Ozdemir O, Ozkan K (2013) Effect of Acticoat® and Cutinova Hydro® on wound healing. Int Wound J 10(5):549–554. https://doi.org/10.1111/j.1742-481X.2012.01021.x

Article  PubMed  Google Scholar 

Armstrong DG, Boulton AJM, Bus SA (2017) Diabetic foot ulcers and their recurrence. N Engl J Med 376(24):2367–2375. https://doi.org/10.1056/nejmra1615439

Article  PubMed  Google Scholar 

Arribas-López E, Zand N, Ojo O, Snowden MJ, Kochhar T (2022) A systematic review of the effect of Centella asiatica on wound healing. Int J Environ Res Public Health 19(6):3266. https://doi.org/10.3390/ijerph19063266

Article  CAS  PubMed  PubMed Central  Google Scholar 

Atkinson MA, Eisenbarth GS, Michels AW (2014) Type 1 diabetes. Lancet 383(9911):69–82. https://doi.org/10.1016/s0140-6736(13)60591-7

Article  PubMed  Google Scholar 

Azis HA, Taher M, Ahmed AS, Sulaiman WMAW, Susanti D, Chowdhury SR, Zakaria ZA (2017) In vitro and in vivo wound healing studies of methanolic fraction of Centella asiatica extract. S Afr J Bot 108:163–174. https://doi.org/10.1016/j.sajb.2016.10.022

Article  Google Scholar 

Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M (2008) Growth factors and cytokines in wound healing. Wound Repair Regen 16(5):585–601. https://doi.org/10.1111/j.1524-475x.2008.00410.x

Article  PubMed  Google Scholar 

Bitar MS (1997) Insulin-like growth factor-1 reverses diabetes-induced wound healing impairment in rats. Horm Metab Res 29(8):383–386. https://doi.org/10.1055/s-2007-979060

Article  CAS  PubMed  Google Scholar 

Bitar MS, Labbad ZN (1996) Transforming growth factor-β and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing. J Surg Res 61(1):113–119. https://doi.org/10.1006/jsre.1996.0090

Article  CAS  PubMed  Google Scholar 

Brem H, Tomic-Canic M (2007) Cellular and molecular basis of wound healing in diabetes. J Clin Invest 117(5):1219–1222. https://doi.org/10.1172/jci32169

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brizeno LAC, Assreuy AMS, Alves APN, Sousa FB, Silva PGDB, de Sousa SCOM, Mota MRL (2016) Delayed healing of oral mucosa in a diabetic rat model: implication of TNF-α, IL-1β and FGF-2. Life Sci 155:36–47. https://doi.org/10.1016/j.lfs.2016.04.033

Article  CAS  PubMed  Google Scholar 

Burgess JL, Wyant WA, Abdo Abujamra B, Kirsner RS, Jozic I (2021) Diabetic wound-healing science. Medicina 57(10):1072. https://doi.org/10.3390/medicina57101072

Article  PubMed  PubMed Central  Google Scholar 

Chakraborty R, Borah P, Dutta PP, Sen S (2022) Evolving spectrum of diabetic wound: mechanistic insights and therapeutic targets. World J Diabetes 13(9):696. https://doi.org/10.4239/wjd.v13.i9.696

Article  PubMed  PubMed Central  Google Scholar 

Dehghani S, Dalirfardouei R, Jafari Najaf Abadi MH, Ebrahimi Nik M, Jaafari MR, Mahdipour E (2020) Topical application of curcumin regulates the angiogenesis in diabetic-impaired cutaneous wound. Cell Biochem Funct 38(5):558–566. https://doi.org/10.1002/cbf.3500

Article  CAS  PubMed  Google Scholar 

Diniz LRL, Calado LL, Duarte ABS, de Sousa DP (2023) Centella asiatica and its metabolite asiatic acid: wound healing effects and therapeutic potential. Metabolites 13(2):276. https://doi.org/10.3390/metabo13020276

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ermertcan AT, Inan S, Ozturkcan S, Bilac C, Cilaker S (2008) Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study. Wound Repair Regen 16(5):674–681. https://doi.org/10.1111/j.1524-475x.2008.00417.x

Article  PubMed  Google Scholar 

Furman BL (2015) Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol 70(1):5–47. https://doi.org/10.1002/0471141755.ph0547s70

Article  Google Scholar 

Galkowska H, Olszewski WL, Wojewodzka U, Rosinski G, Karnafel W (2006) Neurogenic factors in the impaired healing of diabetic foot ulcers. J Surg Res 134(2):252–258. https://doi.org/10.1016/j.jss.2006.02.006

Article  CAS  PubMed  Google Scholar 

Garoufalia Z, Papadopetraki A, Karatza E, Vardakostas D, Philippou A, Kouraklis G, Mantas D (2021) Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: a systematic review of the literature and future perspectives. Biomed Rep 15(2):66. https://doi.org/10.3892/br.2021.1442

Article  CAS  PubMed  PubMed Central  Google Scholar 

González P, Lozano P, Ros G, Solano F (2023) Hyperglycemia and oxidative stress: an integral, updated and critical overview of their metabolic interconnections. Int J Mol Sci 24(11):9352. https://doi.org/10.3390/ijms24119352

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo SA, DiPietro LA (2010) Factors affecting wound healing. J Dent Res 89(3):219–229. https://doi.org/10.1177/0022034509359125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hou Q, Li M, Lu YH, Liu DH, Li CC (2016) Burn wound healing properties of asiaticoside and madecassoside. Exp Ther Med 12(3):1269–1274. https://doi.org/10.3892/etm.2016.3459

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang K, Mi B, Xiong Y, Fu Z, Zhou W, Liu W, Dai G (2025) Angiogenesis during diabetic wound repair: from mechanism to therapy opportunity. Burns Trauma 13:tkae052. https://doi.org/10.1093/burnst/tkae052

Article  PubMed  PubMed Central  Google Scholar 

Ivens UI, Steinkjer B, Serup J, Tetens V (2001) Ointment is evenly spread on the skin, in contrast to creams and solutions. Br J Dermatol 145(2):264–267. https://doi.org/10.1046/j.1365-2133.2001.04344.x

Article  CAS  PubMed  Google Scholar 

Kimura Y, Sumiyoshi M, Samukawa KI, Satake N, Sakanaka M (2008) Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol 584(2–3):415–423. https://doi.org/10.1016/j.ejphar.2008.02.036

Article  CAS  PubMed  Google Scholar 

Lapmanee S, Bunwatcharaphansakun P, Phongsupa W, Namdee K, Suttisintong K, Asawapirom U, Khongkow M (2025) Transfersomal delivery of Centella asiatica promotes efficient excision wound healing in rats. Drug Deliv 32(1):2563649. https://doi.org/10.1080/10717544.2025.2563649

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R, Meng Z, Xie J (2008) Effects of sulfur dioxide on the expressions of EGF, EGFR, and COX-2 in airway of asthmatic rats. Arch Environ Contam Toxicol 54(4):748–757. https://doi.org/10.1007/s00244-007-9054-9

Article  CAS  PubMed  Google Scholar 

Lin P, Shi HY, Lu YY, Lin J (2023) Centella asiatica alleviates p