Alimi H, Ben Salah G, Ben Saad A (2023) Heavy metal exposure impairs neurotrophic signaling and synaptic plasticity. Neurochem Res 48:1725–1737. https://doi.org/10.1007/s11064-023-03845-9

Article  Google Scholar 

ASVCP (2019) Quality assurance guidelines for veterinary hematology laboratories. American Society for Veterinary Clinical Pathology

Bancroft JD, Gamble M (2021) Theory and practice of histological techniques, 8th edn. Elsevier

Boadi NO, Adjei CO, Kusi-Mensah K (2021) Lead-induced neuroinflammation and cytokine dysregulation in experimental models. Environ Toxicol 36:2335–2346. https://doi.org/10.1002/tox.23349

Article  CAS  Google Scholar 

Bradberry SM (2009) Dimercaptosuccinic acid (DMSA) in inorganic lead poisoning. Clin Toxicol 47(7):617–626. https://doi.org/10.1080/15563650903158882

Article  Google Scholar 

Coon Koon Biotech (2024) Rat cytokine ELISA kit instruction manual. Shanghai Coon Koon Biotechnology Co., Ltd.

Crowther JR (2022) The ELISA guidebook, 3rd edn. Springer. https://doi.org/10.1007/978-1-0716-1872-7

FineTest (2023) Wuhan Fine Biotech Co Ltd. Rat-DAB (Poly-HRP) detection IHC kit protocol & antibody datasheets (Catalog Nos. IHC0008, FNab04325, FNab00978). FineTest

Gao H, Liu S, Zhang Y, Zhao D (2023) Polydatin attenuates inflammation and oxidative stress in toxicological models. Front Pharmacol 14:1187642. https://doi.org/10.3389/fphar.2023.1187642

Article  Google Scholar 

Heo JD, Kim JH, Lee JH (2020) Chronic heavy metal exposure and experimental toxicity models. Environ Toxicol Pharmacol 77:103384. https://doi.org/10.1016/j.etap.2020.103384

Article  CAS  Google Scholar 

Hossain MF, Rahman MM, Alam MA (2021) Determination of inflammatory cytokines using sandwich ELISA. In: Methods in Molecular Biology, Vol. 2310. Springer, pp 55–67 https://doi.org/10.1007/978-1-0716-1433-0_5

Ikechukwu NE, Adebayo JO, Ogunyemi EO (2021) Neurotrophic factor depletion in heavy metal–induced neurotoxicity. Toxicol Rep 8:1538–1547. https://doi.org/10.1016/j.toxrep.2021.09.006

Article  CAS  Google Scholar 

Karami A, Fakhri S, Kooshki L, Khan H (2022) Polydatin: Pharmacological mechanisms, therapeutic targets, biological activities, and health benefits. Molecules 27(19):6474. https://doi.org/10.3390/molecules27196474

Karami M, Ghaffari S, Mohammadi A (2022) Pharmacological properties and therapeutic potential of polydatin: a comprehensive review. Phytother Res 36:2271–2288. https://doi.org/10.1002/ptr.7432

Article  CAS  Google Scholar 

Kumar S, Singh R, Chauhan LK (2022) Chronic lead exposure induces neuroinflammation and cognitive impairment. Environ Toxicol Pharmacol 91:103827. https://doi.org/10.1016/j.etap.2022.103827

Article  Google Scholar 

Liang L, Zeng J, Liu R, et al (2024) Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway. Biochemical Pharmacology. https://doi.org/10.1016/j.bcp.2024

Lin Z, Xiong Y, Hu Y, et al (2021) Polydatin ameliorates osteoporosis via suppression of the MAPK signaling pathway. Frontiers in Cell and Developmental Biology, 9:730362. https://doi.org/10.3389/fcell.2021.730362

Luijerink MS, Zhao Y, Liu X (2024) Immunohistochemical assessment of GFAP and BDNF expression in rodent neurotoxicity models. Brain Res Bull 212:111–123. https://doi.org/10.1016/j.brainresbull.2024.03.011

Article  Google Scholar 

Merck Veterinary Manual (2024) Hematologic reference ranges for laboratory animals. Merck & Co

Nix BA, Jensen KJ, Cheng L (2020) Quantitative cytokine analysis by ELISA in rodent plasma. In Methods in Molecular Biology (Vol. 2110, pp. 85–97). Springer. https://doi.org/10.1007/978-1-0716-0260-3_7

Obeng-Gyasi E (2022) Sources of lead exposure, effects on health, and prevention strategies. Int J Environ Res Public Health 19:9502. https://doi.org/10.3390/ijerph19159502

Article  CAS  Google Scholar 

OECD (2001) OECD guideline for testing of chemicals No. 425: Acute oral toxicity—Up-and-down procedure. OECD Publishing

OECD (2021) OECD guideline for testing of chemicals No. 407: Repeated dose 28-day oral toxicity study in rodents. OECD Publishing

Sedeek EK, Soliman MM, Abdel-Daim MM (2022) Lead-induced immune dysregulation and oxidative stress. Environ Sci Pollut Res 29:34521–34534. https://doi.org/10.1007/s11356-021-18274-6

Article  Google Scholar 

Sigma-Aldrich (Merck KGaA). (2024). Polydatin (CAS 65914-17-2) product information / reference standard.

Soliman MM, Abdel-Daim, MM (2020) Novel polydatin-loaded chitosan nanoparticles for safe and efficient type 2 diabetes therapy: In silico, in vitro and in vivo approaches. International Journal of Biological Macromolecules, 154, 1496–1504. https://doi.org/10.1016/j.ijbiomac.2019.11.03110

Sysmex Europe SE. (2023). Literature list – haematology parameters in COVID-19. (company technical document/report)

Tang Q, Liu Y, Zhang H (2022) Safety and pharmacological profile of polydatin in experimental models. Biomed Pharmacother 150:113038. https://doi.org/10.1016/j.biopha.2022.113038

Article  CAS  Google Scholar 

Wang X, Liu Y, Zhao H, Zhang R (2023) Neuroinflammatory and histopathological alterations following chronic lead exposure. Environ Toxicol 38:789–799. https://doi.org/10.1002/tox.23681

Article  CAS  Google Scholar 

Xu Q, Li M, Sun Y, Huang J (2024) Protective effects of polydatin in experimental toxicity models. J Biochem Mol Toxicol 38:e23418. https://doi.org/10.1002/jbt.23418

Article  Google Scholar 

Yang J, Liu Q, Zhang H, Wu Z (2024) Activation of Nrf2/HO-1 signaling by polydatin alleviates oxidative and inflammatory injury. Int J Mol Sci 25:1894. https://doi.org/10.3390/ijms25031894

Article  CAS  Google Scholar 

Zhang Y, He X, Li J (2024) Experimental models of lead-induced neurotoxicity. Environ Res 240:117778. https://doi.org/10.1016/j.envres.2023.117778

Article  CAS  Google Scholar 

Zhao H, Wang L, Chen Z (2021) Mechanisms of lead-induced hematotoxicity. Toxicol Mech Methods 31:529–538. https://doi.org/10.1080/15376516.2021.1900194

Article  Google Scholar 

Zhao X, Liu Y, Zhang Y (2023) Role of NF-κB signaling in lead-induced neurotoxicity. J Neurochem 166:245–258. https://doi.org/10.1111/jnc.15789

Article  CAS  Google Scholar 

Zhou Y, Wang D, Liu X (2021) Protective role of polydatin against heavy metal–induced organ toxicity. Environ Toxicol Pharmacol 88:103742. https://doi.org/10.1016/j.etap.2021.10374

Article  Google Scholar