Agrawal A, Verma I, Shah V et al (2016) Cardiac manifestations of idiopathic pulmonary fibrosis. Intractable Rare Dis Res 5:70–75

Article  PubMed  PubMed Central  Google Scholar 

Alonzo M, Delgado M, Cleetus C et al (2020) Methods for histological characterization of cryo-induced myocardial infarction in a rat model. Acta Histochem 122:151624

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alrashdi BM, Askar H, Germoush MO et al (2025) Cardioprotective, anti-inflammatory, and antioxidative outcome of costus against bleomycin-induced cardiotoxicity in rat model. J Genet Eng Biotechnol 23:100466

Article  PubMed  PubMed Central  Google Scholar 

Assaf N, Salem NA, Khalil WK et al (2011) Evaluation of the potential toxicity of dibromoacetonitrile-induced apoptosis and tumor-initiating activity in rat liver. Food Chem Toxicol 49:3055–3062

Article  CAS  PubMed  Google Scholar 

Atasoy BM, Özgen Z, Bostanci K et al (2012) The effect of magnesium and vitamin E pre-treatments on irradiationinduced oxidative injury of cardiac and pulmonary tissues in rats: a randomized experimental study. Anatol J Cardiol Kardiyol Derg 12

Ayala P, Montenegro J, Vivar R et al (2012) Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp Mol Pathol 92:97–104. https://doi.org/10.1016/j.yexmp.2011.10.012

Article  CAS  PubMed  Google Scholar 

Ayik S, Yildiz A, Ozhan O et al (2025) Cardiovascular impact of consumption of sulfured-dried Malatya apricots (Prunus armeniaca L.) at varying SO2 levels: a comprehensive assessment in a rat model. Food Chem Toxicol 115654

Bestanchuk E, Gozhenko A, Kashchenko O et al (2021) Cardiotoxic effect of bleomycin with a single administration in the experiment. J Educ Health Sport 11:242–251

Article  Google Scholar 

Borges EL, de Barros Pinheiro M, Prata LO et al (2014) Effect of lung fibrosis on glycogen content in different extrapulmonary tissues. Lung 192:125–131

Article  CAS  PubMed  Google Scholar 

Chen K, Chen L, Ouyang Y et al (2020) Pirfenidone attenuates homocysteine–induced apoptosis by regulating the connexin 43 pathway in H9C2 cells. Int J Mol Med. https://doi.org/10.3892/ijmm.2020.4497

Article  PubMed  PubMed Central  Google Scholar 

Cheng WP, Wang BW, Shyu KG (2009) Regulation of GADD153 induced by mechanical stress in cardiomyocytes. Eur J Clin Invest 39:960–971. https://doi.org/10.1111/j.1365-2362.2009.02193.x

Article  CAS  PubMed  Google Scholar 

Elblehi SS, El-Sayed YS, Soliman MM, Shukry M (2021) Date palm pollen extract avert doxorubicin-induced cardiomyopathy fibrosis and associated oxidative/nitrosative stress, inflammatory cascade, and apoptosis-targeting Bax/Bcl-2 and Caspase-3 signaling pathways. Animals 11:886

Article  PubMed  PubMed Central  Google Scholar 

Erden ES, Kirkil G, Deveci F et al (2008) Effects of erdosteine on inflammation and fibrosis in rats with pulmonary fibrosis induced by bleomycin. Tuberk Ve Toraks 56:127–138

Google Scholar 

Erdogmus Ozgen Z, Erdinc M, Kelle İ et al (2022) Protective effects of necrostatin-1 on doxorubicin-induced cardiotoxicity in rat heart. Hum Exp Toxicol 41:09603271211066066. https://doi.org/10.1177/09603271211066066

Article  CAS  Google Scholar 

Groenendyk J, Sreenivasaiah PK, Kim DH et al (2010) Biology of endoplasmic reticulum stress in the heart. Circ Res 107:1185–1197. https://doi.org/10.1161/CIRCRESAHA.110.227033

Article  CAS  PubMed  Google Scholar 

Guan R, Wang X, Zhao X et al (2016) Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation. Sci Rep 6:35696

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamada H, Suzuki M, Yuasa S et al (2004) Dilated Cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice. Mol Cell Biol 24:8007–8017. https://doi.org/10.1128/MCB.24.18.8007-8017.200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hosseini SM, Taghiabadi E, Abnous K et al (2017) Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats. Iran J Basic Med Sci 20:927

PubMed  PubMed Central  Google Scholar 

Inomata M, Kamio K, Azuma A et al (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis. Respir Res 15:16. https://doi.org/10.1186/1465-9921-15-16

Article  PubMed  PubMed Central  Google Scholar 

Jafari A, Pourrazi H, Nikookheslat S, Baradaran B (2015) Effect of exercise training on Bcl-2 and bax gene expression in the rat heart. Gene Cell Tissue 2:e32833

Article  Google Scholar 

Lin W, Chen H, Chen X, Guo C (2024) The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: the new progress. Antioxidants 13:132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma T, Kandhare AD, Mukherjee-Kandhare AA, Bodhankar SL (2019) Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-α. Mol Biol Rep 46:105–118

Article  CAS  PubMed  Google Scholar 

Marciniak SJ, Yun CY, Oyadomari S et al (2004) CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 18:3066–3077

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazières J, Brugger W, Cappuzzo F et al (2013) Evaluation of EGFR protein expression by immunohistochemistry using H-score and the magnification rule: re-analysis of the SATURN study. Lung Cancer 82:231–237

Article  PubMed  Google Scholar 

Mou F, Mou C (2020) Necrostatin-1 alleviates bleomycin-induced pulmonary fibrosis and extracellular matrix expression in interstitial pulmonary fibrosis. Med Sci Monit Int Med J Exp Clin Res 26:e919739–e919731

CAS  Google Scholar 

Muldoon MF, Kritchevsky SB (1996) Flavonoids and heart disease. BMJ 312:458–459

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nathan SD, Basavaraj A, Reichner C et al (2010) Prevalence and impact of coronary artery disease in idiopathic pulmonary fibrosis. Respir Med 104:1035–1041

Article  PubMed  Google Scholar 

Ohkawa H (1978) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 98:351

Google Scholar 

Rao RV, Ellerby HM, Bredesen DE (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11:372–380

Article  CAS  PubMed  Google Scholar 

Salem NA, Salem EA (2011) Renoprotective effect of grape seed extract against oxidative stress induced by gentamicin and hypercholesterolemia in rats. Ren Fail 33:824–832

Article  CAS  PubMed  Google Scholar 

Santos-Ribeiro D, Lecocq M, De Beukelaer M et al (2023) Bleomycin‐induced lung injury: revisiting an old tool to model group III PH associated with pulmonary fibrosis. Pulm Circ 13:e12177. https://doi.org/10.1002/pul2.12177

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarı EN, Soysal Y (2020) Molecular and therapeutic effects of fisetin flavonoid in diseases. J Basic Clin Health Sci 4:190–196

Google Scholar 

Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25:192–205

Article  CAS  PubMed  Google Scholar 

Shahbaz M, Kamran SH, Anwar R (2021) Amelioration of bleomycin and methotrexate-induced pulmonary toxicity by Serratiopeptidase and Fisetin. Nutr Cancer 73:2774–2784. https://doi.org/10.1080/01635581.2020.1860242

Article  CAS  PubMed  Google Scholar