Accurate and comprehensive evaluation of three-dimensional (3D) pelvic-floor-muscle (PFM) strength distributions are highly expected to play a crucial role in clinical early diagnosis and physiotherapy precise treatment of women’s pelvic-floor-dysfunction (PFD). However, clinically existing PFM-evaluating methods merely assess a rough and synthetical PFM strength from the whole vagina muscle tunnel, seriously restricting the development of PFD-related diagnostic methodologies and therapeutic interventions. Here, 3D complex female PFM-strength distributions have been accurately detected by developing a portable multi-channel PFM-pressure dynamic measuring system. Clinical trials demonstrate the superiority in high PFM-strength sensitivity and 3D spatial resolution, offering the opportunities to imply specific deficits in personalized PFM functions and customized interventions accordingly. Significantly, various subclinical PFM abnormalities can be identified by the 3D accurate PFM-strength distributions, which is not possible using traditional PFM-evaluating methods, providing a visual biomechanical foundation for clinical early diagnosis and physiotherapy precise treatment of PFD. Combined with the additional advance in physical comfortability, patients-friendliness universality, and stability without motion artifact achieved by the novel designed vaginal probe, this proof of concept research holds the promise for paradigm revolution in PFM pathological research, and promotes the transformation of clinical pelvic-floor medicine from empirical medicine to data-driven precision medicine.

The authors have declared no competing interest.

This work was funded by the National Key Research and Development Program of China (2021YFC2009100), the Science and Technology Department of Sichuan Province Project (2023YFS0024), and the Sichuan Provincial Health Commission Project (21ZD002).

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

The Research Medical Ethics Committee of the West China Second University Hospital in Sichuan University gave ethical approval for this work.

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