Freedman MS, Gnanapavan S, Booth RA, Calabresi PA, Khalil M, Kuhle J, Lycke J, Olsson T (2024) Guidance for use of neurofilament light chain as a cerebrospinal fluid and blood biomarker in multiple sclerosis management. EBioMedicine 101:104970. https://doi.org/10.1016/j.ebiom.2024.104970
Article CAS PubMed PubMed Central Google Scholar
Suh A, Hampel G, Vinjamuri A, Ong J, Kamran SA, Waisberg E, Paladugu P, Zaman N et al (2024) Oculomics analysis in multiple sclerosis: current ophthalmic clinical and imaging biomarkers. Eye 38(14):2701–2710. https://doi.org/10.1038/s41433-024-03132-y
Article PubMed PubMed Central Google Scholar
Agarwal R, Risk BB, Sandlin DS, Mulamalla AR, Sadigh G, Allen JW, Fleischer CC (2024) Effects of financial toxicity and socioeconomic status on MRI follow‐up time in multiple sclerosis. Clin Neuroimaging. https://doi.org/10.1002/neo2.10
Fleischer V, Brummer T, Muthuraman M, Steffen F, Heldt M, Protopapa M, Schraad M, Gonzalez-Escamilla G et al (2025) Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis. Front Immunol 16:1532660. https://doi.org/10.3389/fimmu.2025.1532660
Article CAS PubMed PubMed Central Google Scholar
Asl ER, Hosseini SE, Tahmasebi F, Bolandi N, Barati S (2025) MiR-124 and MiR-155 as therapeutic targets in microglia-mediated inflammation in multiple sclerosis. Cell Mol Neurobiol 45(1):63. https://doi.org/10.1007/s10571-025-01578-6
Article CAS PubMed PubMed Central Google Scholar
Nikanfar M, Nouri M, Hassanpour M, Rezaei J, Nourazarian A (2025) Elevated miRNA-21, miRNA-155, and miRNA-182 levels correlate with cytokine dysregulation in neurological disorders and indicate potential for biomarker and therapy development. Sci Rep 15(1):23523. https://doi.org/10.1038/s41598-025-05372-8
Article CAS PubMed PubMed Central Google Scholar
Koruyucu D, Can Demirdöğen B (2025) Exploring miRNA inhibiting therapeutic strategies for multiple sclerosis: insights from experimental autoimmune encephalomyelitis studies – a traditional review. Sağlık Bilimlerinde Değer 15(3):498–508. https://doi.org/10.33631/sabd.1560606
Sanadgol N, Samadi M, Voelz C, Khalseh R, Amini J, Beyer C, Kipp M, Clarner T (2025) Genomic ncRNAs regulating mitochondrial function in neurodegeneration: a neglected clue in the complex etiopathogenesis of multiple sclerosis. Cell Biosci 15(1):93. https://doi.org/10.1186/s13578-025-01438-2
Article CAS PubMed PubMed Central Google Scholar
Yousefi MJ, Afshar Y, Amoozadehsamakoosh A, Naseri A, Soltani F, Yazdanpanah N, Saleki K, Rezaei N (2025) Interplay between innate-like T-cells and microRNAs in cancer immunity. Discov Oncol 16(1):1425. https://doi.org/10.1007/s12672-025-03234-3
Article CAS PubMed PubMed Central Google Scholar
Zare E, Yaghoubi SM, Khoshnazar M, Jafari Dargahlou S, Machhar JS, Zheng Z, Duijf PHG et al (2025) MicroRNAs in cancer immunology: master regulators of the tumor microenvironment and immune evasion, with therapeutic potential. Cancers (Basel). https://doi.org/10.3390/cancers17132172
Gauthier T, Martin-Rodriguez O, Chague C, Daoui A, Ceroi A, Varin A, Bonnefoy F, Valmary-Degano S et al (2023) Amelioration of experimental autoimmune encephalomyelitis by in vivo reprogramming of macrophages using pro-resolving factors. J Neuroinflammation 20(1):307. https://doi.org/10.1186/s12974-023-02994-5
Article CAS PubMed PubMed Central Google Scholar
Ahlberg E, Al-Kaabawi A, Thune R, Simpson MR, Pedersen SA, Cione E, Jenmalm MC, Tingo L (2023) Breast milk microRNAs: potential players in oral tolerance development. Front Immunol 14:1154211. https://doi.org/10.3389/fimmu.2023.1154211
Article CAS PubMed PubMed Central Google Scholar
Liu YJ, Miao HB, Lin S, Chen Z (2023) Current progress in treating systemic lupus erythematosus using exosomes/microRNAs. Cell Transplant 32:9636897221148775. https://doi.org/10.1177/09636897221148775
Shi Q, Gutierrez RA, Bhat MA (2025) Microglia, Trem2, and neurodegeneration. Neuroscientist 31(2):159–176. https://doi.org/10.1177/10738584241254118
Article CAS PubMed Google Scholar
Doroszkiewicz J, Winkel I, Mroczko B (2025) Comparative analysis of neuroinflammatory pathways in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis: insights into similarities and distinctions. Front Neurosci 19:1579511. https://doi.org/10.3389/fnins.2025.1579511
Article PubMed PubMed Central Google Scholar
He C, Chen B, Yang H, Zhou X (2025) The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression. Front Aging Neurosci 17:1554398. https://doi.org/10.3389/fnagi.2025.1554398
Article CAS PubMed PubMed Central Google Scholar
Cross AH, Gelfand JM, Thebault S, Bennett JL, von Budingen HC, Cameron B, Carruthers R, Edwards K et al (2024) Emerging cerebrospinal fluid biomarkers of disease activity and progression in multiple sclerosis. JAMA Neurol 81(4):373–383. https://doi.org/10.1001/jamaneurol.2024.0017
Article PubMed PubMed Central Google Scholar
Yu H, Zhang L, Song B, Ren K, Chen X, Dai Y, Yang Y, Xu Y et al (2025) TREM2-mediated regulation of microglial activity: a promising target for the treatment of ischemic stroke. J Transl Med 23(1):782. https://doi.org/10.1186/s12967-025-06799-3
Article PubMed PubMed Central Google Scholar
Wang X, Wang Y, Yang L, Zhang Y, Yang L (2025) TREM2(+) macrophages: a key role in disease development. Front Immunol 16:1550893. https://doi.org/10.3389/fimmu.2025.1550893
Article CAS PubMed PubMed Central Google Scholar
McCray TJ (2025) The role of TREM2 and the responses mediated by Galectin-3 during age-related myelin degeneration. Indiana University-Purdue University Indianapolis
Rinaldi A (2025) Microglia derived extracellular vesicles (EVs) in brain aging: a rejuvenation approach. Sapienza University of Rome
Chen Y, Yin P, Chen Q, Zhang Y, Tang Y, Jin W, Yu L (2025) Neurodegenerative diseases and immune system: from pathogenic mechanism to therapy. Neural Regen Res. https://doi.org/10.4103/NRR.NRR-D-25-00274
Article PubMed PubMed Central Google Scholar
Vermersch P, Airas L, Berger T, Deisenhammer F, Grigoriadis N, Hartung HP, Magyari M, Popescu V et al (2025) The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors. Front Immunol 16:1495529. https://doi.org/10.3389/fimmu.2025.1495529
Article CAS PubMed PubMed Central Google Scholar
Bettcher BM, de Oliveira FF, Willette AA, Michalowska MM, Machado LS, Rajbanshi B, Borelli WV, Tansey MG et al (2025) Analysis and interpretation of inflammatory fluid markers in Alzheimer’s disease: a roadmap for standardization. J Neuroinflammation 22(1):105. https://doi.org/10.1186/s12974-025-03432-4
Article PubMed PubMed Central Google Scholar
Heneka MT, Gauthier S, Chandekar SA, Hviid Hahn-Pedersen J, Bentsen MA, Zetterberg H (2025) Neuroinflammatory fluid biomarkers in patients with Alzheimer’s disease: a systematic literature review. Mol Psychiatry 30(6):2783–2798. https://doi.org/10.1038/s41380-025-02939-9
Article PubMed PubMed Central Google Scholar
Hok AHYS, Del Campo M, Boiten WA, Stoops E, Vanhooren M, Lemstra AW, van der Flier WM, Teunissen CE (2023) Neuroinflammatory CSF biomarkers MIF, sTREM1, and sTREM2 show dynamic expression profiles in Alzheimer’s disease. J Neuroinflammation 20(1):107. https://doi.org/10.1186/s12974-023-02796-9
Asih PR, Morris CW, Wang H, Pedrini S, Goozee K, Laws SM, Chatterjee P, Taddei K et al (2025) Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer’s disease. preprint. https://doi.org/10.1101/2025.08.11.25333037
Zhang L, Xiang X, Li Y, Bu G, Chen XF (2025) TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies. Mol Neurodegener 20(1):43. https://doi.org/10.1186/s13024-025-00834-z
Article CAS PubMed PubMed Central Google Scholar
Maeda T, Mizutani Y, Ohdake R, Nagao R, Kawabata K, Shima S, Ueda A, Ito M et al (2025) Elevated levels of cerebrospinal fluid soluble triggering receptor expressed on myeloid cells 2 in multiple system atrophy: a marker of disease-associated microglial activation. J Neural Transm (Vienna).
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