Background Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global mortality, with persistent lung inflammation contributing to disease progression. This inflammation is partly associated with reduced levels of histone deacetylase 2 (HDAC2). Previous studies suggest that Vitamin D may modulate HDAC2 levels. This study aimed to evaluate the effect of Vitamin D supplementation on HDAC2 expression in stable COPD patients. This experimental study aimed to evaluate the effect of vitamin D supplementation on HDAC2 expression in stable COPD patients at Jemursari Islamic Hospital.

Methods Five COPD patients received a daily dose of 5000 IU of Vitamin D for three months. Serum levels of 25(OH)D3 and HDAC2 were measured before and after the intervention.

Results Vitamin D supplementation resulted in a significant increase in both 25(OH)D3 and HDAC2 levels. Pulmonary function parameters showed an increasing trend, however, no statistically significant differences were observed.

Conclusion Vitamin D supplementation was associated with increased HDAC2 levels, suggesting a potential anti-inflammatory effect. However, no significant improvement in pulmonary function was observed. Further studies are needed to determine its clinical impact.

The authors have declared no competing interest.

TCTR20260405002

This research was supported by Universitas Nahdlatul Ulama Surabaya (UNUSA) under the Letter of Assignment No. 023.92/UNUSA-LPPM/Adm.E/ST-Pen/III/2024

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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:

This study was approved by the Ethics Committee of Komisi Etik Penelitian Kesehatan Rumah Sakit Islam Surabaya Jemursari, with approval number 052/KEPK-RSISJS/V/2024.

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