Mechanism of Anticoagulation, Inhibition of Thrombus Formation, and Assessment of Preclinical Safety of a Snake Venom Phospholipase A Enzyme-inspired New Antithrombotic Custom Peptide

Blaszczyk M, Ciemny MP, Kolinski A, Kurcinski M, Kmiecik S (2019) Protein–peptide docking using CABS-dock and contact information. Brief Bioinform 20:2299–2305. https://doi.org/10.1093/bib/bby080

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borissoff JI, Spronk HM, ten Cate H (2011) The hemostatic system as a modulator of atherosclerosis. N Engl J Med 364:1746–1760. https://doi.org/10.1056/NEJMra1011670

Article  CAS  PubMed  Google Scholar 

Brown MA, Stenberg LM, Stenflo J (2013) Coagulation Factor Xa. Handb Proteolytic Enzymes 9:2908–2915. https://doi.org/10.1016/B978-0-12-382219-2.00642-6

Article  Google Scholar 

Campbell WR, Hanna MI (1937) The albumin, globulins, and fibrinogen of serum and plasma. J Biol Chem 119:15–33. https://doi.org/10.1016/S0021-9258(18)74428-1

Article  CAS  Google Scholar 

Cappello M, Bergum PW, Vlasuk GP, Furmidge BA, Pritchard DI, Aksoy S (1996) Isolation and characterization of the tsetse thrombin inhibitor: a potent antithrombotic peptide from the saliva of Glossina morsitans morsitans. Am J Trop Med Hyg 54:475–480. https://doi.org/10.4269/ajtmh.1996.54.475

Article  CAS  PubMed  Google Scholar 

Chan YS, Cheung RCF, Xia L, Wong JH, Ng TB, Chan WY (2016) Snake venom toxins: toxicity and medicinal applications. Appl Microbiol Biotechnol 100:6165–6181. https://doi.org/10.1007/s00253-016-7610-9

Article  CAS  PubMed  Google Scholar 

Chen F, Huang G (2020) Mechanism and inhibition kinetics of peptide P13 as thrombin inhibitor. Int J Biol Macromol 150:1046–1052. https://doi.org/10.1016/j.ijbiomac.2019.10.109

Article  CAS  PubMed  Google Scholar 

Chen M, Ye X, Ming X, Chen Y, Wang Y, Su X, Su W, Kong Y (2015) A novel direct Factor Xa inhibitory peptide with antiplatelet aggregation activity from Agkistrodon acutus venom hydrolysates. Sci Rep 5:10846. https://doi.org/10.1038/srep10846

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciprandi A, de Oliveira SK, Masuda A, Horn F, Termignoni C (2006) Boophilus microplus: its saliva contains microphilin, a small thrombin inhibitor. Exp Parasitol 114:40–46. https://doi.org/10.1016/j.exppara.2006.02.010

Article  CAS  PubMed  Google Scholar 

Cossy J, Belotti D (2001) A short synthesis of argatroban a potent selective thrombin inhibitor. Bioorg Med Chem Lett 11:1989–1992. https://doi.org/10.1016/s0960-894x(01)00351-1

Article  CAS  PubMed  Google Scholar 

Craik DJ, Fairlie DP, Liras S, Price D (2013) The future of peptide-based drugs. Chem Biol Drug Des 81:136–147. https://doi.org/10.1111/cbdd.12055

Article  CAS  PubMed  Google Scholar 

Davie EW, Fujikawa K, Kisiel W (1991) The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 30:10363–10370. https://doi.org/10.1021/bi00107a001

Article  CAS  PubMed  Google Scholar 

De Groot AS, Scott DW (2007) Immunogenicity of protein therapeutics. Trends Immunol 28:482–490. https://doi.org/10.1016/j.it.2007.07.011

Article  CAS  PubMed  Google Scholar 

Di Cera E (2008) Thrombin. Mol Aspects Med 29:203–254. https://doi.org/10.1016/j.mam.2008.01.001

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Veroli GY, Fornari C, Goldlust I, Mills G, Koh SB, Bramhall JL, Richards FM, Jodrell DI (2015) An automated fitting procedure and software for dose-response curves with multiphasic features. Sci Rep 5:14701. https://doi.org/10.1038/srep14701

Article  CAS  PubMed  PubMed Central  Google Scholar 

Doley R, Mukherjee AK (2003) Purification and characterization of an anticoagulant phospholipase A(2) from Indian monocled cobra (Naja kaouthia) venom. Toxicon 41(1):81–91. https://doi.org/10.1016/s0041-0101(02)00213-1

Article  CAS  PubMed  Google Scholar 

Dougall IG, Unitt J (2015) Evaluation of the biological activity of compounds: techniques and mechanism of action studies, In The Practice of Medicinal Chemistry, The Practice of Medicinal Chemistry. Elsevier 15–43. https://doi.org/10.1016/B978-0-12-417205-0.00002-X

Dutta S, Gogoi D, Mukherjee AK (2015) Anticoagulant mechanism and platelet deaggregation property of a non-cytotoxic, acidic phospholipase A2 purified from Indian cobra (Naja naja) venom: inhibition of anticoagulant activity by low molecular weight heparin. Biochimie 110:93–106. https://doi.org/10.1016/j.biochi.2014.12.020

Article  CAS  PubMed  Google Scholar 

Esmon CT (2014) Targeting factor Xa and thrombin: impact on coagulation and beyond. Thromb Haemost 111:625–633. https://doi.org/10.1160/th13-09-0730

Article  CAS  PubMed  Google Scholar 

Fenton JW, Ofosu FA, Brezniak DV, Hassouna HI (1993) Understanding thrombin and hemostasis. Hematol Oncol Clin North Am 7:1107–1119. https://doi.org/10.1016/S0889-8588(18)30201-6

Article  PubMed  Google Scholar 

Fosgerau K, Hoffmann T (2015) Peptide therapeutics: current status and future directions. Drug Discov Today 20:122–128. https://doi.org/10.1016/j.drudis.2014.10.003

Article  CAS  PubMed  Google Scholar 

Gerlier D, Thomasset N (1986) Use of MTT colorimetric assay to measure cell activation. J Immunol Methods 94:57–63. https://doi.org/10.1016/0022-1759(86)90215-2

Article  CAS  PubMed  Google Scholar 

Giannis D, Ziogas IA, Gianni P (2020) Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol 127:104362. https://doi.org/10.1016/j.jcv.2020.104362

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girish VM, Kini, RM (2016) Exactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus. Sci Rep 6:32036. https://doi.org/10.1038/srep32036

Gogoi D, Arora N, Kalita B, Sarma R, Islam T, Ghosh SS, Devi R, Mukherjee AK (2018) Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin(ogen)olytic serine protease from leaves of Leucas indica. Sci Rep 8:6210. https://doi.org/10.1038/s41598-018-24422-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heron M, National Center for Health Statistics (2013) Deaths: leading causes for 2010. National vital statistics reports: from the Centers for Disease Control and Prevention. Natl Vital Stat Rep 62:1–96. https://stacks.cdc.gov/view/cdc/21434/cdc_21434_DS1.pdf

PubMed  Google Scholar 

Hirsh J, O’Donnell M, Weitz JI (2005) New anticoagulants. Blood 105:453–463. https://doi.org/10.1182/blood-2003-12-4195

Article  CAS  PubMed  Google Scholar 

Horstkotte D, Schulte HD, Bircks W, Strauer BE (1994) Lower intensity anticoagulation therapy results in lower complication rates with the St. Jude Medical prosthesis. J Thorac Cardiovasc Surg 107:1136–1145. https://doi.org/10.1016/S0022-5223(94)70391-4

Article  CAS  PubMed  Google Scholar 

Howell W (1935) Theories of blood coagulation. Physiol Rev 15:435–470. https://doi.org/10.1152/physrev.1935.15.3.435

Article  CAS  Google Scholar 

Huntington JA (2005) Molecular recognition mechanisms of thrombin. J Thromb Haemost 3(8):1861–1872. https://doi.org/10.1111/j.1538-7836.2005.01363.x

Article  CAS  PubMed  Google Scholar 

Iannaccone PM, Jacob HJ (2009) Rats! Dis Model Mech 2:206–210.

Comments (0)

No login
gif