Agrawal RP, Budania S, Sharma P, Gupta R, Kochar DK, Panwar RB, Sahani MS (2007) Zero prevalence of diabetes in camel milk consuming Raica community of north-west Rajasthan, India. Diabetes Res Clin Pract 76(2):290–296. https://doi.org/10.1016/j.diabres.2006.09.036

Article  CAS  PubMed  Google Scholar 

An N, Yang J, Zhang Y, Suo H, Song J (2025) Enzymatic hydrolysis of buffalo casein enhances DPP-4 inhibition: Structural modifications and bioactive peptide identification. J Dairy Sci 108(3):2169–2181. https://doi.org/10.3168/jds.2024-25552

Article  CAS  PubMed  Google Scholar 

Ayoub MA, Yap PG, Mudgil P, Khan FB, Anwar I, Muhammad K, Maqsood S (2024) Camel milk-derived bioactive peptides and diabetes: Molecular view and perspectives. J Dairy Sci 107(2):649–668. https://doi.org/10.3168/jds.2023-23733

Article  CAS  PubMed  Google Scholar 

Baig D, Sabikhi L, Khetra Y, Kumar D (2022) Effect of casein to fat ratio of camel milk on solids losses in cheese whey and their recovery in camel milk cheese. Int Dairy J 124:105185. https://doi.org/10.1016/j.idairyj.2021.105185

Article  CAS  Google Scholar 

Bhat DK, Kanga U, Kumar N, Agrawal RP, Mourya M, Kalaivani M, Mehra NK (2014) The Raikas: A unique combination of high prevalence of type 1 diabetes susceptibility genes and near zero incidence of the disease. Hum Immunol 75(12):1252–1258. https://doi.org/10.1016/j.humimm.2014.09.009

Article  CAS  PubMed  Google Scholar 

Bolleddula J, Brady K, Bruin G, Lee A, Martin JA, Walles M, Yu H (2022) Absorption, distribution, metabolism, and excretion of therapeutic proteins: Current industry practices and future perspectives. Drug Metab Dispos 50(6):837–845. https://doi.org/10.1124/dmd.121.000461

Article  CAS  PubMed  Google Scholar 

Cassidy CS, Lin J, Frey PA (1997) A new concept for the mechanism of action of chymotrypsin: The role of the low-barrier hydrogen bond. Biochemistry 36(15):4576–4584. https://doi.org/10.1021/bi962013o

Article  CAS  PubMed  Google Scholar 

Chen C, Li H, Zhang J, Wang Y, Li Y (2023) Alterations in β-cell calcium dynamics and efficacy outweigh islet mass adaptation in compensation of insulin resistance and prediabetes onset. Cell Rep 42(1):112–123. https://doi.org/10.2337/db15-1718

Article  CAS  Google Scholar 

Department of Animal Husbandry and Dairying (2019) 20th livestock census. Government of India, New Delhi. https://ruralindiaonline.org/en/library/resource/20th-livestock-census-2019-all-india-report/. Accessed 22 Nov 2025

Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes. Endocr Rev 23(5):599–622. https://doi.org/10.1210/er.2001-0039

Article  CAS  PubMed  Google Scholar 

Gahlot RK, Jyotsana B, Prakash V, Narnaware SD, Rathore NS (2023) Molecular characterization of toll-like receptor 2 gene in Bikaneri camels. Indian J Anim Sci 93(7):706–710

Article  CAS  Google Scholar 

García-Moreno PJ, Espejo-Carpio FJ, Guadix A, Guadix EM (2015) Production and identification of ACE-inhibitory peptides from Mediterranean fish discards. J Funct Foods 18:95–105. https://doi.org/10.1016/j.jff.2015.06.062

Article  CAS  Google Scholar 

Guo H, Pan L, Wu Q et al (2025) Type 2 diabetes and the multifaceted Gut-X axes. Nutrients 17(16):2708. https://doi.org/10.3390/nu17162708

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jia CL, Hussain N, Ujiroghene OJ, Pang XY, Zhang SW, Lu J et al (2020) Generation and characterization of DPP-IV inhibitory peptides from trypsin-hydrolyzed α-lactalbumin-rich whey proteins. Food Chem 318:126333. https://doi.org/10.1016/j.foodchem.2020.126333

Article  CAS  PubMed  Google Scholar 

Kalyan S, Meena S, Kapila S, Yadav R, Deshwal GK (2021) In vitro assessment of antioxidative potential of goat milk, casein and its hydrolysates: Comparison of goat milk with bovine and buffalo milk. Indian J Dairy Sci 74(5):402–408. https://doi.org/10.33785/ijds.2021.v74i05.004

Article  Google Scholar 

Kalyan S, Raman RK, Meena S (2025) Impact of low-molecular-weight (< 3 kDa) camel milk casein and whey protein hydrolysates on hyperglycemia and associated hyperlipidemia, oxidative stress, and reproductive health in type 2 diabetic male rats. ACS Food Sci Technol 5(9):3507–3519. https://doi.org/10.1021/acsfoodscitech.5c00548

Article  CAS  Google Scholar 

Kamal H, Jafar S, Mudgil P, Murali C, Amin A, Maqsood S (2018) Inhibitory properties of camel whey protein hydrolysates toward liver cancer cells, dipeptidyl peptidase-IV, and inflammation. J Dairy Sci 101(10):8711–8720. https://doi.org/10.3168/jds.2018-14586

Article  CAS  PubMed  Google Scholar 

Khan SH, Devi U, Yadav R, Meena S, Kapila R, Kapila S (2026) Anti-diabetic effect of camel milk and protein hydrolysates in rat model. Mol Biol Rep 53(1):131. https://doi.org/10.1007/s11033-025-11275-8

Article  CAS  Google Scholar 

Komatsu Y, Wada Y, Izumi H, Shimizu T, Takeda Y, Hira T, Hara H (2019) Casein materials show different digestion patterns using an in vitro gastrointestinal model and different release of glucagon-like peptide-1 by enteroendocrine GLUTag cells. Food Chem 277:423–431. https://doi.org/10.1016/j.foodchem.2018.10.123

Article  CAS  PubMed  Google Scholar 

Lacroix IME, Li-Chan ECY (2014) Isolation and characterization of DPP-IV inhibitory peptides from bovine whey proteins. Peptides 54:39–48. https://doi.org/10.1016/j.peptides.2014.01.002

Article  CAS  PubMed  Google Scholar 

Li L, El-Kholy W, Rhodes CJ, Brubaker PL (2005) Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia 48(7):1339–1349. https://doi.org/10.1007/s00125-005-1787-2

Article  CAS  PubMed  Google Scholar 

Magliano D, Boyko EJ (2025) IDF Diabetes Atlas, 11th edn. International Diabetes Federation, Brussels. https://diabetesatlas.org/resources/idf-diabetes-atlas-2025/#. Accessed 15 Oct 2025

Mashili F, Chibalin AV, Krook A, Zierath JR (2013) Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes 62(2):457–465. https://doi.org/10.2337/db12-0337

Article  CAS  PubMed  Google Scholar 

Ministry of Fisheries, Animal Husbandry and Dairying (2022) Breed-wise report of livestock and poultry based on 20th livestock census. Government of India. https://www.pib.gov.in/PressReleasePage.aspx?PRID=1824647. Accessed 22 Nov 2025

Mudgil P, Kamal H, Yuen GC, Maqsood S (2018) Characterization and identification of novel antidiabetic and anti-obesity peptides from camel milk protein hydrolysates. Food Chem 259:46–54. https://doi.org/10.1016/j.foodchem.2018.03.082

Article  CAS  PubMed  Google Scholar 

Nithyasree V, Magdalene P, Praveen Kumar PK, Preethi J, Gromiha MM (2024) Role of HSP90 in type 2 diabetes mellitus and its association with liver diseases. Mol Biotechnol. https://doi.org/10.1007/s12033-024-01251-1

Article  PubMed  Google Scholar 

Nongonierma AB, Mooney C, Shields DC, FitzGerald RJ (2013) Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chem 141(1):644–653. https://doi.org/10.1016/j.foodchem.2013.02.115

Article  CAS  PubMed  Google Scholar 

Nongonierma AB, Paolella S, Mudgil P, Maqsood S, FitzGerald RJ (2018) Identification of novel DPP-IV inhibitory peptides in camel milk protein hydrolysates. Food Chem 244:340–348. https://doi.org/10.1016/j.foodchem.2017.10.033

Article  CAS  PubMed  Google Scholar 

Sahoo A, Patel S (2021) Camel husbandry in India: Challenges and perspectives. In: Sahoo A, Sawal RK (eds) Opportunities and constraints in camel production system and its sustainability. ICAR–National Research Centre on Camel, Bikaner, India, pp 1–11

Google Scholar 

Salami M, Yousefi R, Ehsani MR, Dalgalarrondo M, Chobert JM, Haertlé T, Moosavi-Movahedi AA (2008) Kinetic characterization of hydrolysis of camel and bovine milk proteins by pancreatic enzymes. Int Dairy J 18(12):1097–1102. https://doi.org/10.1016/j.idairyj.2008.06.003

Article  CAS  Google Scholar 

Shanmugam VP, Kapila S, Kemgang TS, Reddi S, Kapila R, Muthukumar S, Rajesh D (2021) Isolation and characterization of angiotensin converting enzyme inhibitory peptide from buffalo casein. Int J Pept Res Ther 27(2):1481–1491. https://doi.org/10.1007/s10989-021-10185-0

Article  CAS  Google Scholar 

Smith PE, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano M et al (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150(1):76–85. https://doi.org/10.1016/0003-2697(85)90442-7