ReDLat2 is supported mainly by the US National Institute on Aging (R01 AG057234). A.I. is supported by grants from ReDLat, including the Fogarty International Center, the US National Institutes of Health (NIH), the US National Institute on Aging (R01 AG057234, R01 AG075775, R01 AG21051, R01 AG083799, CARDS-NIH and R01 AG057234), the Alzheimer’s Association (SG-20-725707), the Rainwater Charitable Foundation – The Bluefield project to cure FTD, and Global Brain Health Institute, and Agencia Nacional de Investigación y Desarrollo (ANID)/Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) Regular (1250091 and 1210176 and 1220995); ANID/PIA/ANILLOS ACT210096; EU Joint Programme – Neurodegenerative Disease Research (JPND-Care), DISCeRN 2025 - Health and Social Care Research with a Focus on the Moderate and Late Stages of Neurodegenerative Diseases; FONDEF ID20I10152 and ANID/FONDAP 15150012; a Wellcome Trust award for BRAIN-CLIMA: Investigating the Combined Impact of Heat and Air Pollution on Blood-Brain Barrier Integrity and Brain Aging in Latin America (335293/Z/25/Z); the Wellcome Leap CARE Program (CARE-2025-0883490149) for the project “Advancing Female-Specific Predictive Models and Risk Assessment Tools for Alzheimer’s Disease in the US and Latin America; and CliCBrain (Horizon ID, 101236426; Marie Skłodowska-Curie Actions). C.D.-A. is supported by is supported by grants from ReDLat2, supported by Fogarty International Center, the NIH, the US National Institute on Aging (R01 AG057234, R01 AG075775, R01 AG21051, R01 AG083799 and CARDS-NIH), the Alzheimer’s Association (SG-20-725707), the Rainwater Charitable Foundation – The Bluefield project to cure FTD, and Global Brain Health Institute, ANID/FONDECYT Regular (1210622 and 1250091), ANID/NAM22I0007, the Alzheimer’s Association (AARGD-24-1310017), ANID/FOVI240065, ANID/Proyecto Exploracion 13240170, the Wellcome Leap CARE Program (CARE-2025-0883490149), CliCBrain (Horizon ID, 101236426) and A2026019S BrightFocus Foundation Standard Award Program in Alzheimer’s Disease Research. J.S.Y. receives funding from the NIH National Institute on Aging (R01AG057234, P30AG062422, P01AG019724, and U19AG079774); the NIH National Institute of Neurological Disorders and Stroke (U54NS123985); the Rainwater Charitable Foundation; the Alzheimer’s Association; the Global Brain Health Institute; and the Mary Oakley Foundation. The contents of this publication are solely the responsibility of the authors and do not represent the official views of these institutions, including the NIH. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.