Case Report Oncocytic intraductal papillary neoplasm of the pancreas: Multimodality imaging and cytopathologic correlation

Anju Ranga, Pranav Gupta, Agrima Bansal, Ravindra K. Saran, Sudeshdeep Sinha, Kalpana Bansal

South African Journal of Radiology | Vol 30, No 1 | a3390 | DOI: https://doi.org/10.4102/sajr.v30i1.3390 | © 2026 Anju Ranga, Pranav Gupta, Agrima Bansal, Ravindra K. Saran, Sudeshdeep Sinha, Kalpana Bansal | This work is licensed under CC Attribution 4.0
Submitted: 02 February 2026 | Published: 20 May 2026

About the author(s) Anju Ranga, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India
Pranav Gupta, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India
Agrima Bansal, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India
Ravindra K. Saran, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India
Sudeshdeep Sinha, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India
Kalpana Bansal, Department of Radiology, Govind Ballabh Pant Hospital, New Delhi, India

Abstract

Intraductal oncocytic papillary neoplasm of the pancreas (IOPN-P) is a rare cystic epithelial tumour with distinctive imaging, cytological and histological features. This case report describes a 65-year-old female who presented with abdominal pain and vomiting for 6 months and was later diagnosed with IOPN-P. Multimodality imaging, including ultrasound, contrast-enhanced CT, MRI, MRCP and endoscopic ultrasound, played an important role in lesion evaluation. Cytopathological evaluation and immunohistochemistry confirmed the diagnosis.
Contribution: The case highlights the importance of recognising radiological features of IOPN-P to differentiate it from more aggressive pancreatic neoplasms.

Keywords

intraductal oncocytic papillary neoplasm; IOPN; pancreatic cystic neoplasm; MRI pancreas; mural nodule

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