Lee, S. and Jeong, K.H., Patterns and determinants of medication adherence among older adult patients with diabetes in Korea: Insights from a nationwide survey, BMC Geriatr., 2025, vol. 25, no. 1, p. 366. https://doi.org/10.1186/s12877-025-05915-8
Rock, A.E., Russell, M.L., and Triant, V.A., Balancing polypharmacy and comorbidity management: Cardiovascular health, Curr. Opin. HIV AIDS, 2025, vol. 20, no. 4, pp. 409–415. https://doi.org/10.1097/COH.0000000000000948
Salh, H.J.H., Aziz, T.A., Mahwi, T.O., Hussen, N.H., and Aziz, D.F., The relation between polypharmacy, potentially inappropriate medications, organ function, and quality of life in elderly patients with type 2 diabetes, Hosp. Pharm., 2025, p. 00185787251337592. https://doi.org/10.1177/00185787251337592
Cruz-Jentoft, A.J., Bahat, G., Bauer, J., Boirie, Y., Bruyere, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A.A., Schneider, S.M., Sieber, C.C., Topinkova, E., Vandewoude, M., Visser, M., and Zamboni, M., Sarcopenia: Revised European consensus on definition and diagnosis, Age Ageing, 2019, vol. 48, no. 4, pp. 16–31. https://doi.org/10.1093/ageing/afy169
Papadopoulou, S.K., Tsintavis, P., Potsaki, P., and Papandreou, D., Differences in the prevalence of sarcopenia in community-dwelling, nursing home and hospitalized individuals. A systematic review and meta-analysis, J. Nutr. Health Aging, 2020, vol. 24, no. 1, pp. 83–90. https://doi.org/10.1007/s12603-019-1267-x
Article PubMed CAS Google Scholar
Pedauyé-Rueda, B., García-Fernandez, P., Maicas-Pérez, L., Maté-Muñoz, J.L., and Hernández-Lougedo, J., Different diagnostic criteria for determining the prevalence of sarcopenia in older adults: A systematic review, J. Clin. Med., 2024, vol. 13, no. 9, p. 2520. https://doi.org/10.3390/jcm13092520
Article PubMed PubMed Central Google Scholar
Beaudart, C., Rizzoli, R., Bruyère, O., Reginster, J.Y., and Biver, E., Sarcopenia: Burden and challenges for public health, Arch. Public Health, 2014, vol. 72, no. 1, p. 45. https://doi.org/10.1186/2049-3258-72-45
Article PubMed PubMed Central Google Scholar
Zeng, Z., Ho, C.Y., Sit, C.H., Wong, S.H., Liao, J., and Yang, Y., Effectiveness of exercise intervention on mobility, postural control, and falls for older adults with mild cognitive impairment: A systematic review and network meta-analysis, Arch. Phys. Med. Rehabil., 2025, vol. 106, no. 5, pp. 781–800. https://doi.org/10.1016/j.apmr.2024.12.002
Marques, A. and Queirós, C., Frailty, sarcopenia and falls, in Fragility Fracture Nursing: Holistic Care and Management of the Orthogeriatric Patient, Hertz, K. and Santy-Tomlinson, J., Eds., Springer, Cham, 2018, pp. 13–26. https://pubmed.ncbi.nlm.nih.gov/31314472.
Pana, A., Sourtzi, P., Kalokairinou, A., and Velonaki, V.S., Sarcopenia and polypharmacy among older adults: A scoping review of the literature, Arch. Gerontol. Geriatr., 2022, vol. 98, p. 104520. https://doi.org/10.1016/j.archger.2021.104520
Katsimpris, A., Linseisen, J., Meisinger, C., and Volaklis, K., The association between polypharmacy and physical function in older adults: A systematic review, J. Gen. Intern. Med., 2019, vol. 34, no. 9, pp. 1865–1873. https://doi.org/10.1007/s11606-019-05106-3
Manias, E., Kabir, M.Z., and Maier, A.B., Inappropriate medications and physical function: A systematic review, Ther. Adv. Drug Saf., 2021, vol. 12, p. 20420986211030371. https://doi.org/10.1177/20420986211030371
Article PubMed PubMed Central Google Scholar
de Souza, I.K.C., Rosa-Souza, F.J., de Lucena Alves, C.P., Duhamel, T.A., Waters, D.L., Martins, R.R., and Costa, E.C., Polypharmacy, physical activity, and sedentary time in older adults: A scoping review, Exp. Gerontol., 2023, vol. 183, p. 112317. https://doi.org/10.1016/j.exger.2023.112317
Kuzuya, M., Drug-related sarcopenia as a secondary sarcopenia, Geriatr. Gerontol. Int., 2024, vol. 24, no. 2, pp. 195–203. https://doi.org/10.1111/ggi.14770
Jerzak, P., Kusztal, M., Dziubek, W., Rogowski, Ł., Ostrowska, B., Gołębiowski, M., Bronikowska, P., Chumadevska, M., Stojanowski, J., and Gołębiowski, T., Motor coordination disorders in patients with chronic kidney disease, J. Clin. Med., 2025, vol. 14, no. 8, p. 2804. https://doi.org/10.3390/jcm14082804
Article PubMed PubMed Central CAS Google Scholar
Lai, T.F., Park, J.H., Jang, M., Chen, J., Shin, M.J., Moon, E., Kang, J.M., Lee, J.W., Cho, Y.J., Liao, Y., Goh, T.S., and Lee, J.S., Elevated extracellular water to total body water ratio and low phase angle in relation to muscle function in middle-aged and older adults, J. Int. Soc. Sports Nutr., 2025, vol. 22, no. 1, p. 2536693. https://doi.org/10.1080/15502783.2025.2536693
Article PubMed PubMed Central CAS Google Scholar
Fox, C., Smith, T., Maidment, I., Chan, W.Y., Bua, N., Myint, P.K., Boustani, M., Kwok, C.S., Glover, M., Koopmans, I., and Campbell, N., Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: A systematic review, Age Ageing, 2014, vol. 43, no. 5, pp. 604–615. https://doi.org/10.1093/ageing/afu096
Goto, S., Sasaki, A., Takahashi, I., Mitsuhashi, Y., Nakaji, S., and Matsubara, A., Relationship between cognitive function and balance in a community-dwelling population in Japan, Acta Otolaryngol., 2018, vol. 138, no. 5, pp. 471–474. https://doi.org/10.1080/00016489.2017.1408142
Roubenoff, R., Physical activity, inflammation, and muscle loss, Nutr. Rev., 2007, vol. 65, 12 Pt. 2, pp. S208–S212. https://doi.org/10.1111/j.1753-4887.2007.tb00364.x
McDermott, M.M., Liu, K., Ferrucci, L., Tian, L., Guralnik, J.M., Liao, Y., and Criqui, M.H., Decline in functional performance predicts later increased mobility loss and mortality in peripheral arterial disease, J. Am. Coll. Cardiol., 2011, vol. 57, no. 8, pp. 962–970. https://doi.org/10.1016/j.jacc.2010.09.053
Folstein, M.F., Folstein, S.E., and McHugh, P.R., “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician, J. Psychiatr. Res., 1975, vol. 12, no. 3, pp. 189–198. https://doi.org/10.1016/0022-3956(75)90026-6
Widen, E.M., Strain, G., King, W.C., Yu, W., Lin, S., Goodpaster, B., Thornton, J., Courcoulas, A., Pomp, A., and Gallagher, D., Validity of bioelectrical impedance analysis for measuring changes in body water and percent fat after bariatric surgery, Obes. Surg., 2014, vol. 24, no. 6, pp. 847–854. https://doi.org/10.1007/s11695-014-1182-5
Article PubMed PubMed Central Google Scholar
Ritz, P. and Source Study, Bioelectrical impedance analysis estimation of water compartments in elderly diseased patients: The source study, J. Gerontol. A Biol. Sci. Med. Sci., 2011, vol. 56, no. 6, pp. M344–M348. https://doi.org/10.1093/gerona/56.6.m344
van Marken Lichtenbelt, W.D., Westerterp, K.R., Wouters, L., and Luijendijk, S.C., Validation of bioelectrical-impedance measurements as a method to estimate body-water compartments, Am. J. Clin. Nutr., 1994, vol. 60, no. 2, pp. 159–166. https://doi.org/10.1093/ajcn/60.2.159
Article PubMed CAS Google Scholar
Martinoli, R., Mohamed, E.I., Maiolo, C., Cianci, R., Denoth, F., Salvadori, S., and Iacopino, L., Total body water estimation using bioelectrical impedance: A meta-analysis of the data available in the literature, Acta Diabetol., 2003, vol. 40, suppl. 1, pp. S203–S206. https://doi.org/10.1007/s00592-003-0066-2
Simpson, J.A., Lobo, D.N., Anderson, J.A., Macdonald, I.A., Perkins, A.C., Neal, K.R., Allison, S.P., and Rowlands, B.J., Body water compartment measurements: A comparison of bioelectrical impedance analysis with tritium and sodium bromide dilution techniques, Clin. Nutr. (Edinburgh, Scotland), 2001, vol. 20, no. 4, pp. 339–343. https://doi.org/10.1054/clnu.2001.0398
Guralnik, J.M., Simonsick, E.M., Ferrucci, L., Glynn, R.J., Berkman, L.F., Blazer, D.G., Scherr, P.A., and Wallace, R.B.,, A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission, J. Gerontol., 1994, vol. 49, no. 2, pp. M85–M94. https://doi.org/10.1093/geronj/49.2.m85
Wearing, J., Konings, P., de Bie, R.A., Stokes, M., and de Bruin, E.D., Prevalence of probable sarcopenia in community-dwelling older Swiss people—a cross-sectional study, BMC Geriatr., 2020, vol. 20, no. 1, p. 307. https://doi.org/10.1186/s12877-020-01718-1
Connolly, K., Cunningham, C., Murphy, N., Romero-Ortuno, R., and Horgan, F., Prevalence of sarcopenia and associated factors in older adults attending a day hospital service in Ireland, Eur. Geriatr. Med., 2021, vol. 12, no. 4, pp. 851–862. https://doi.org/10.1007/s41999-021-00463-x
Pan, S., Li, S., Jiang, S., Shin, J.I., Liu, G.G., Wu, H., and Lyu, B., Trends in number and appropriateness of prescription medication utilization among community-dwelling older adults in the United States: 2011–2020, J. Gerontol. A Biol. Sci. Med. Sci., 2024, vol. 79, no. 7, p. glae108. https://doi.org/10.1093/gerona/glae108
Rawle, M.J., Cooper, R., Kuh, D., and Richards, M., Associations between polypharmacy and cognitive and physical capability: A British birth cohort study, J. Am. Geriatr. Soc., 2018, vol. 66, no. 5, pp. 916–923. https://doi.org/10.1111/jgs.15317
Eyigor, S., Kutsal, Y.G., Toraman, F., Durmus, B., Gokkaya, K.O., Aydeniz, A., Paker, N., and Borman, P., Polypharmacy, physical and nutritional status, and depression in the elderly: Do polypharmacy deserve some credits in these problems?, Exp. Aging Res., 2021, vol. 47, no. 1, pp. 79–91. https://doi.org/10.1080/0361073X.2020.1846949
Ozkok, S., Aydin, C.O., Sacar, D.E., Catikkas, N.M., Erdogan, T., Kilic, C., Karan, M.A., and Bahat, G., Associations between polypharmacy and physical performance measures in older adults, Arch. Gerontol. Geriatr., 2022, vol. 98, p. 104553. https://doi.org/10.1016/j.archger.2021.104553
Article PubMed CAS Google Scholar
Mohamed, M.R., Juba, K., Awad, H., Flannery, M., Culakova, E., Wells, M., Cacciatore, J., Jensen-Battaglia, M., Mohile, S., and Ramsdale, E., Effect of polypharmacy and potentially inappropriate medications on physical functional decline among older adults with advanced cancer receiving systemic treatment, Support. Care Cancer, 2024, vol. 32, no. 10, p. 674. https://doi.org/10.1007/s00520-024-08877-6
Katsimpris, A., Linseisen, J., Meisinger, C., and Volaklis, K., The association between polypharmacy and physical function in older adults: A systematic review, J. Gen. Intern. Med., 2019, vol. 34, no. 9, pp. 1865–1873. https://doi.org/10.1007/s11606-019-05106-3
Manias, E., Kabir, M.Z., and Maier, A.B., Inappropriate medications and physical function: A systematic review, Ther. Adv. Drug. Saf., 2021, vol. 12, p. 20420986211030371. https://doi.org/10.1177/20420986211030371
Article PubMed PubMed Central Google Scholar
George, C. and Verghese, J., Polypharmacy and gait performance in community-dwelling older adults, J. Am. Geriatr. Soc., 2017, vol. 65, no. 9, pp. 2082–2087. https://doi.org/10.1111/jgs.14957
Sganga, F., Vetrano, D.L., Volpato, S., Cherubini, A., Ruggiero, C., Corsonello, A., Fabbietti, P., Lattanzio, F., Bernabei, R., and Onder, G., Physical performance measures and polypharmacy among hospitalized older adults: Results from the CRIME study, J. Nutr. Health Aging, 2014, vol. 18, no. 6, pp. 616–621. https://doi.org/10.1007/s12603-014-0029-z
MacKinnon, D.P., Taborga, M.P., and Morgan-Lopez, A.A., Mediation designs for tobacco prevention research, Drug Alcohol Depend., 2002, vol. 68, suppl. 1, pp. S69–S83. https://doi.org/10.1016/s0376-8716(02)00216-8
Article PubMed PubMed Central Google Scholar
Layne, A.S., Hsu, F.C., Blair, S.N., Chen, S.H., Dungan, J., Fielding, R.A., Glynn, N.W., Hajduk, A.M., King, A.C., Manini, T.M., Marsh, A.P., Pahor, M., Pellegrini, C.A., Buford, T.W., and LIFE Study Investigator, Predictors of change in physical function in older adults in response to long-term, structured physical activity: The LIFE study, Arch. Phys. Med. Rehabil., 2017, vol. 98, no. 1, pp. 11–24.e3. https://doi.org/10.1016/j.apmr.2016.07.019
Patel, K.V., Coppin, A.K., Manini, T.M., Lauretani, F., Bandinelli, S., Ferrucci, L., and Guralnik, J.M., Midlife physical activity and mobility in older age: The InCHIANTI study, Am. J. Prev. Med., 2006, vol. 31, no. 3, pp. 217–224. https://doi.org/10.1016/j.amepre.2006.05.005
Article PubMed PubMed Central Google Scholar
Yamada, Y., Schoeller, D.A., Nakamura, E., Morimoto, T., Kimura, M., and Oda, S., Extracellular water may mask actual muscle atrophy during aging, J. Gerontol. A Biol. Sci. Med. Sci., 2010, vol. 65, no. 5, pp. 510–516. https://doi.org/10.1093/gerona/glq001
Taniguchi, M., Yamada, Y., Fukumoto, Y., Sawano, S., Minami, S., Ikezoe, T., Watanabe, Y., Kimura, M., and Ichihashi, N., Increase in echo intensity and extracellular-to-intracellular water ratio is independently associated with muscle weakness in elderly women, Eur. J. Appl. Physiol., 2017, vol. 117, no. 10, pp. 2001–2007. https://doi.org/10.1007/s00421-017-3686-x
Park, K.S., Lee, G.Y., Seo, Y.M., Seo, S.H., and Yoo, J.I., The relationship between extracellular water-to-body water ratio and sarcopenia according to the newly revised Asian Working Group for Sarcopenia: 2019 Consensus Update, Aging Clin. Exp. Res., 2021, vol. 33, no. 9, pp. 2471–2477. https://doi.org/10.1007/s40520-020-01766-y
Ishiyama, D., Yamada, M., Makino, A., Iwasaki, S., Otobe, Y., Shinohara, A., Nishio, N., Kimura, Y., Itagaki, A., Koyama, S., Yagi
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