Blazer D, Hughes DC, George LK (1987) The epidemiology of depression in an elderly community population. Gerontologist 27:281–287. https://doi.org/10.1093/geront/27.3.281
Article CAS PubMed Google Scholar
Braida D, Donzelli A, Martucci R, Capurro V, Busnelli M, Chini B, Sala M (2012) Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish. Psychopharmacol 220:319–330. https://doi.org/10.1007/s00213-011-2482-2
Coker RH, Wolfe RR (2012) Bedrest and sarcopenia. Curr Opin Clin Nutr Metab Care 15:7–11. https://doi.org/10.1097/MCO.0b013e32834da629
Article PubMed PubMed Central Google Scholar
Costa FV, Kolesnikova TO, Galstyan DS, Ilyin NP, de Abreu MS, Petersen EV, Demin KA, Yenkoyan KB, Kalueff AV (2023) Current state of modeling human psychiatric disorders using zebrafish. Int J Mol Sci 24:3187. https://doi.org/10.3390/ijms24043187
Article CAS PubMed PubMed Central Google Scholar
Gemmer A, Mirkes K, Anneser L, Eilers T, Kibat C, Mathuru A, Ryu S, Schuman E (2022) Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Sci Rep 12:4322. https://doi.org/10.1038/s41598-022-07990-y
Article CAS PubMed PubMed Central Google Scholar
Ghisleni G, Capiotti KM, Da Silva RS, Oses JP, Piato ÂL, Soares V, Bogo MR, Bonan CD (2012) The role of CRH in behavioral responses to acute restraint stress in zebrafish. Prog Neuropsychopharmacol Biol Psychiatry 36:176–182. https://doi.org/10.1016/j.pnpbp.2011.08.016
Article CAS PubMed Google Scholar
Herbison AE (1997) Estrogen regulation of GABA transmission in rat preoptic area. Brain Res Bull 44:321–326. https://doi.org/10.1016/S0361-9230(97)00210-4
Article CAS PubMed Google Scholar
Hermans RCJ, Engels RCME, Larsen JK, Herman CP (2009) Modeling of palatable food intake. The influence of quality of social interaction. Appetite 52:801–804. https://doi.org/10.1016/j.appet.2009.03.008
Hibarino M, Aoki E, Kubo Y, Nagata H, Tateno S, Sakaguchi K, Kawaji H, Shiozaki K (2024) Lactic acid-fermented by-product of Shochu distillery reduces anxiety behavior in Neuropeptide Y knockout zebrafish by the regulation of isotoin neuron. J Mater Cycles Waste Manag 26:3852–3863. https://doi.org/10.1007/s10163-024-02092-5
Ishikawa H, Kawakami N, Kessler RC (2016) Lifetime and 12-month prevalence, severity and unmet need for treatment of common mental disorders in Japan: results from the final dataset of World Mental Health Japan Survey. Epidemiol Psychiatr Sci 25:217–229. https://doi.org/10.1017/S2045796015000566
Article CAS PubMed Google Scholar
Ivanova T, Küppers E, Engele J, Beyer C (2001) Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism. J Neurosci Res 66:221–230. https://doi.org/10.1002/jnr.1214
Article CAS PubMed Google Scholar
Kawabe M, Hayashi A, Komatsu M, Inui A, Shiozaki K (2021) Ninjinyoeito improves anxiety behavior in neuropeptide Y deficient zebrafish. Neuropeptides 87:102136. https://doi.org/10.1016/j.npep.2021.102136
Article CAS PubMed Google Scholar
Kawabe M, Nishida T, Horita C, Ikeda A, Takahashi R, Inui A, Shiozaki K (2022) Ninjinyoeito improves social behavior disorder in neuropeptide Y deficient zebrafish. Front Pharmacol 13:905711. https://doi.org/10.3389/fphar.2022.905711
Article CAS PubMed PubMed Central Google Scholar
Kawabe M, Nishida T, Takahashi R, Inui A, Shiozaki K (2023) Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish. Front Pharmacol 14:1168229. https://doi.org/10.3389/fphar.2023.1168229
Article PubMed PubMed Central Google Scholar
Kitanohara M, Yamamoto T, Masunaga S, Ohishi M, Komatsu Y, Nagase M (2017) Effect of porcine placental extract on the mild menopausal symptoms of climacteric women. Climacteric 20:144–150. https://doi.org/10.1080/13697137.2017.1279140
Article CAS PubMed Google Scholar
Kormos V, Gaszner B (2013) Role of neuropeptides in anxiety, stress, and depression: From animals to humans. Neuropeptides 47:401–419. https://doi.org/10.1016/j.npep.2013.10.014
Article CAS PubMed Google Scholar
Laosam P, Panpipat W, Yusakul G, Cheong L, Chaijan M (2021) Porcine placenta hydrolysate as an alternate functional food ingredient: in vitro antioxidant and antibacterial assessments. PLoS ONE 16:e0258445. https://doi.org/10.1371/journal.pone.0258445
Article CAS PubMed PubMed Central Google Scholar
Lee J, Jo D, Moon S, Kong J, Park T, Ko Y, Song Y, Lee J (2012) Narrative review of clinical trials on hominis placenta pharmacopuncture in Korean literature. J Korean Med RehabilJ Orient Rehabil Med 22:79– 88
Lee J, Lee C, Yoon S, Choi H (2020) Effect of porcine placental extract on menopausal symptoms in postmenopausal women: A prospective, randomized, double-blind, placebo-controlled trial. Taiwan J Obstet Gynecol 59:675–681. https://doi.org/10.1016/j.tjog.2020.07.009
Lu Q, Ling N (2024) Research progress on active ingredients, pharmacological effects and clinical applications of Ziheche (dried human placenta). Chin Arch Tradit Chin Med 42:232–236
Lucon-Xiccato T, Tomain M, D’Aniello S, Bertolucci C (2023) bdnf loss affects activity, sociability, and anxiety-like behaviour in zebrafish. Behav Brain Res 436:114115. https://doi.org/10.1016/j.bbr.2022.114115
Article CAS PubMed Google Scholar
Maniezzi C, Talpo F, Spaiardi P, Toselli M, Biella G (2019) Oxytocin increases phasic and tonic GABAergic transmission in CA1 region of mouse hippocampus. Front Cell Neurosci 13:178. https://doi.org/10.3389/fncel.2019.00178
Article CAS PubMed PubMed Central Google Scholar
Meguro K, Yamaguchi S (2018) Decreased behavioral abnormalities after treatment with combined donepezil and Yokukansankachimpihange in Alzheimer disease: An observational study. The Osaki-Tajiri Project. Neurol Ther 7:333–340. https://doi.org/10.1007/s40120-018-0109-9
Article PubMed PubMed Central Google Scholar
Mizoguchi K, Ikeda R, Shoji H, Tanaka Y, Jin X, Kase Y, Takeda S, Maruyama W, Tabira T (2009) Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam. J Nat Med 63:69–74. https://doi.org/10.1007/s11418-008-0281-9
Moos FC (1995) GABA-induced facilitation of the periodic bursting activity of oxytocin neurones in suckled rats. J Physiol 488:103–114. https://doi.org/10.1113/jphysiol.1995.sp020949
Article CAS PubMed PubMed Central Google Scholar
Morita N, Hirano E (2025) Supplementation with porcine placenta extract reduces negative emotions and enhances positive emotions in healthy adults: a randomized, double-blind, placebo-controlled study. Front Nutr 12:1570736. https://doi.org/10.3389/fnut.2025.1570736
Article CAS PubMed PubMed Central Google Scholar
Murata K, Fujita N, Takahashi R, Inui A (2018) Ninjinyoeito improves behavioral abnormalities and hippocampal neurogenesis in the corticosterone model of depression. Front Pharmacol 9:1216. https://doi.org/10.3389/fphar.2018.01216
Article CAS PubMed PubMed Central Google Scholar
Nishida T, Horita C, Imagawa M, Hibarino M, Tateno S, Kubo Y, Kawabe M, Morishita N, Endo S, Shiozaki K (2023) Glucosyl hesperidin exhibits more potent anxiolytic activity than hesperidin accompanied by the attenuation of noradrenaline induction in a zebrafish model. Front Pharmacol 14:1213252. https://doi.org/10.3389/fphar.2023.1213252
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