Ellison DH, Felker GM. Diuretic treatment in heart failure. N Engl J Med. 2017;377(20):1964–75.
Article CAS PubMed PubMed Central Google Scholar
Authors/Task Force M, McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2022;24(1):4–131.
Jardim SI, Ramos Dos Santos L, Araujo I, Marques F, Branco P, Gaspar A, et al. A 2018 overview of diuretic resistance in heart failure. Rev Port Cardiol (Engl Ed). 2018;37(11):935–45.
Wu L, Rodriguez M, El Hachem K, Krittanawong C. Diuretic treatment in heart failure: a practical guide for clinicians. J Clin Med. 2024. https://doi.org/10.3390/jcm13154470.
Article PubMed PubMed Central Google Scholar
Meekers E, Martens P, Dauw J, Gruwez H, Dhont S, Nijst P, et al. Nurse-led diuretic titration via a point-of-care urinary sodium sensor in patients with acute decompensated heart failure (EASY-HF): A single-centre, randomized, open-label study. Eur J Heart Fail. 2024;26(10):2129–39.
Article CAS PubMed Google Scholar
Cannata A, Anastasia G, De Marzo V, Caspi O, Bromage D, Porto I, et al. Diuretic strategies in acute heart failure: a systematic review and network meta-analysis of randomized clinical trials. Eur Heart J Cardiovasc Pharmacother. 2026;12(1):6–14.
Article CAS PubMed PubMed Central Google Scholar
Felker GM, Ellison DH, Mullens W, Cox ZL, Testani JM. Diuretic therapy for patients with heart failure: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(10):1178–95.
Article CAS PubMed Google Scholar
Wilcox CS, Testani JM, Pitt B. Pathophysiology of diuretic resistance and its implications for the management of chronic heart failure. Hypertension. 2020;76(4):1045–54.
Article CAS PubMed PubMed Central Google Scholar
Lu X, Xin Y, Zhu J, Dong W, Guan TP, Li JY, et al. Diuretic Resistance Prediction and Risk Factor Analysis of Patients with Heart Failure During Hospitalization. Glob Heart. 2022;17(1):33.
Article PubMed PubMed Central Google Scholar
Segar MW, Khan MS, Patel KV, Butler J, Ravichandran AK, Walsh MN, et al. A phenomapping tool and clinical score to identify low diuretic efficiency in acute decompensated heart failure. JACC Heart Fail. 2024;12(3):508–20.
Article CAS PubMed Google Scholar
Desai RJ, Wang SV, Vaduganathan M, Evers T, Schneeweiss S. Comparison of machine learning methods with traditional models for use of administrative claims with electronic medical records to predict heart failure outcomes. JAMA Netw Open. 2020;3(1):e1918962.
Article PubMed PubMed Central Google Scholar
Wang H, Arulraj T, Kimko H, Popel AS. Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition. NPJ Precis Oncol. 2023;7(1):55.
Article CAS PubMed PubMed Central Google Scholar
Arulraj T, Wang H, Deshpande A, Varadhan R, Emens LA, Jaffee EM, et al. Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade. Proc Natl Acad Sci U S A. 2024;121(45):e2410911121.
Article CAS PubMed PubMed Central Google Scholar
Hu J, Zhao Y, Rao Q, Li G, Jiao Z, Wang H, et al. Combining mechanistic quantitative systems pharmacology modeling and patient-derived organoid testing in MET-aberrant non-small cell lung cancer for high-throughput combination efficacy analysis and personalized treatment design. Front Pharmacol. 2025;16:1685468.
Article CAS PubMed PubMed Central Google Scholar
Yang S, Wang W, Rao Q, Xu Y, Zhang S, Qu Y, et al. Mechanistic data-informed multiscale quantitative systems pharmacology modeling framework enables the clinical translation and efficacy assessment of CAR-T therapy in solid tumors. J Immunother Cancer. 2025;13(10): e012331.
Article PubMed PubMed Central Google Scholar
Zhu AZX, Rogge M. Applications of Quantitative System Pharmacology modeling to model-informed drug development. Methods Mol Biol. 2022;2486:71–86.
Article CAS PubMed Google Scholar
Tindall MJ, Cucurull-Sanchez L, Mistry H, Yates JWT. Quantitative Systems Pharmacology and machine learning: A match made in Heaven or Hell? J Pharmacol Exp Ther. 2023;387(1):92–9.
Article CAS PubMed Google Scholar
Sove RJ, Jafarnejad M, Zhao C, Wang H, Ma H, Popel AS. QSP-IO: A Quantitative Systems Pharmacology toolbox for mechanistic multiscale modeling for Immuno-Oncology applications. CPT Pharmacomet Syst Pharmacol. 2020;9(9):484–97.
Hallow KM, Gebremichael Y. A quantitative systems physiology model of renal function and blood pressure regulation: Model description. CPT Pharmacometrics Syst Pharmacol. 2017;6(6):383–92.
Article CAS PubMed PubMed Central Google Scholar
Shoaf SE, Bramer SL, Bricmont P, Zimmer CA. Pharmacokinetic and pharmacodynamic interaction between tolvaptan, a non-peptide AVP antagonist, and furosemide or hydrochlorothiazide. J Cardiovasc Pharmacol. 2007;50(2):213–22.
Article CAS PubMed Google Scholar
Van Wart SA, Shoaf SE, Mallikaarjun S, Mager DE. Population-based meta-analysis of furosemide pharmacokinetics. Biopharm Drug Dispos. 2014;35(2):119–33.
McMahon BA, Chawla LS. The furosemide stress test: current use and future potential. Ren Fail. 2021;43(1):830–9.
Article PubMed PubMed Central Google Scholar
Liu D, Li L, Rostami-Hodjegan A, Bois FY, Jamei M. Considerations and caveats when applying global sensitivity analysis methods to physiologically based pharmacokinetic models. AAPS J. 2020;22(5):93.
Article CAS PubMed PubMed Central Google Scholar
Aronson D. The interstitial compartment as a therapeutic target in heart failure. Front Cardiovasc Med. 2022;9:933384.
Article PubMed PubMed Central Google Scholar
Brater DC. Diuretic therapy. N Engl J Med. 1998;339(6):387–95.
Article CAS PubMed Google Scholar
Nijst P, Olinevich M, Hilkens P, Martens P, Dupont M, Tang WHW, et al. Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation? Circ Heart Fail. 2018;11(7):e004763.
Ter Maaten JM, Rao VS, Hanberg JS, Perry Wilson F, Bellumkonda L, Assefa M, et al. Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure. Eur J Heart Fail. 2017;19(8):1014–22.
Article PubMed PubMed Central Google Scholar
Stevens PE, Levin A, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group M. Evaluation and management of chronic kidney disease: synopsis of the Kidney Disease: Improving Global Outcomes 2012 clinical practice guideline. Ann Intern Med. 2013;158(11):825–30.
Nijst P, Verbrugge FH, Martens P, Dupont M, Tang WHW, Mullens W. Renal response to intravascular volume expansion in euvolemic heart failure patients with reduced ejection fraction: mechanistic insights and clinical implications. Int J Cardiol. 2017;243:318–25.
Vergaro G, Emdin M, Iervasi A, Zyw L, Gabutti A, Poletti R, et al. Prognostic value of plasma renin activity in heart failure. Am J Cardiol. 2011;108(2):246–51.
Article CAS PubMed Google Scholar
Inoue K, Goldwater D, Allison M, Seeman T, Kestenbaum BR, Watson KE. Serum aldosterone concentration, blood pressure, and coronary artery calcium: the Multi-Ethnic Study of Atherosclerosis. Hypertension. 2020;76(1):113–20.
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