Navigating Ethics in Global Longevity Research: An Analysis of XPRIZE Healthspan’s Clinical Trial Framework

Abadie, R. 2010. The professional guinea pig: Big Pharma and the risky world of human subjects. Durham: Duke University Press.

Book Google Scholar

Aizenberg, M., and A. Brandolini. 2023. Confidentiality and privacy in digital clinical trials. In Handbook of bioethical decisions, Volume II, eds. E. Valdés and J. A. Lecaros, 145–164. Cham: Springer International Publishing. https://doi.org/10.1007/978-3-031-29455-6_11.

Alliance for Longevity Initiatives. 2023. The advanced approval pathway for longevity medicines. Washington, D.C.: The Alliance for Longevity Initiatives.

Al-Naggar, Iman M., Kenneth G. Campellone, Sara E. Espinoza, et al. 2024. Bringing geroscience into the mainstream: From education to clinical practice, what will it take? Journals of Gerontology: Series A, Biological Sciences and Medical Sciences 79 (9): glae020. https://doi.org/10.1093/gerona/glae020.

Aparicio, A. 2024. Life extension should come with wisdom: Reflections and questions for the geroscience and longevity community. Rejuvenation Research 27 (4): 137–142. https://doi.org/10.1089/rej.2024.0028.

Article Google Scholar

Aparicio, A. 2025. Public alignment with longevity biotechnology: An analysis of framing in surveys and opinion studies. Biogerontology 26 (1) : 13. https://doi.org/10.1007/s10522-024-10157-z.

Article Google Scholar

Appelbaum, P. S., L. H. Roth, and C. Lidz. 1982. The therapeutic misconception: Informed consent in psychiatric research. International Journal of Law and Psychiatry 5 (3–4): 319–329. https://doi.org/10.1016/0160-2527(82)90026-7.

Article Google Scholar

ARPA-H. n.d. PROSPR: Proactive solutions for prolonging resilience. https://arpa-h.gov/explore-funding/programs/prospr. Accessed 19 April 2026.

Barzilai, N. 2020. Age later: Health span, life span, and the new science of longevity. New York: St. Martin’s Press.

Bostrom, N. 2005. The fable of the dragon tyrant. Journal of Medical Ethics 31 (5): 273–277. https://doi.org/10.1136/jme.2004.009035.

Article Google Scholar

Callahan, D. 1995. Setting limits: Medical goals in an aging society. Washington, D.C.: Georgetown University Press.

Caplan, A. L. 2005. Death as an unnatural process: Why is it wrong to seek a cure for ageing? EMBO Reports 6 (S1): S72–S75. https://doi.org/10.1038/sj.embor.7400435.

Caplan, A. L. 2017. How can aging be thought of as anything other than a disease? In Handbook of the Philosophy of Medicine, eds. T. Schramme and S. Edwards, 233–240. Dordrecht: Springer Netherlands. https://doi.org/10.1007/978-94-017-8688-1_10.

Cohen, A. A., John R. Beard, Luigi Ferrucci, et al. 2025. Balancing the promise and risks of geroscience interventions. Nature Aging 5:4–8. https://doi.org/10.1038/s43587-024-00788-9.

Davis, J. K. 2018. New Methuselahs: The ethics of life extension. Cambridge, MA: The MIT Press.

Book Google Scholar

De Grey, A. 2005. Life extension, human rights, and the rational refinement of repugnance. Journal of Medical Ethics 31 (11): 659–663. https://doi.org/10.1136/jme.2005.011957.

Article Google Scholar

De Winter, G. 2015. Aging as disease. Medicine, Health Care and Philosophy 18 (2): 237–243. https://doi.org/10.1007/s11019-014-9600-y.

Article Google Scholar

Diamandis, P. 2025. Longevity guidebook: How to Slow, Stop, and Reverse Aging - and NOT Die from Something Stupid. Powell, OH: Ethos Collective.

Emanuel, E. J., D. Wendler, and C. Grady. 2000. What makes clinical research ethical? JAMA 283 (20): 2701. https://doi.org/10.1001/jama.283.20.2701.

Article Google Scholar

Estes, C. L., and E. A. Binney. 1989. The biomedicalization of aging: Dangers and dilemmas. Gerontologist 29 (5): 587–596. https://doi.org/10.1093/geront/29.5.587.

Evans, J.H. 2014. The history and future of bioethics: A sociological view. Oxford: Oxford University Press.

FDA. 2019. Postmarketing clinical trials. https://www.fda.gov/vaccines-blood-biologics/biologics-post-market-activities/postmarketing-clinical-trials. Accessed 19 April 2026.

Farman, A. 2020. On Not Dying: Secular Immortality in the Age of Technoscience. Minneapolis: University of Minnesota Press. https://www.upress.umn.edu/book-division/books/on-not-dying. Accessed 15 September 2023.

Farrelly, C. 2024. Aging, equality and the human healthspan. HEC Forum 36 (2): 187–205. https://doi.org/10.1007/s10730-022-09499-3.

Article Google Scholar

Fukuyama, F. 2002. Our posthuman future: Consequences of the biotechnology revolution. New York: Farrar, Straus and Giroux.

García-Barranquero, P., J. Llorca Albareda, and G. Díaz-Cobacho. 2024. Is ageing undesirable? An ethical analysis. Journal of Medical Ethics 50 (6): 413–419. https://doi.org/10.1136/jme-2022-108823.

Article Google Scholar

Grady, C. 2010. Do IRBs protect human research participants? JAMA 304 (10): 1122. https://doi.org/10.1001/jama.2010.1304.

Article Google Scholar

Hansen, M., and B. K. Kennedy. 2016. Does longer lifespan mean longer healthspan? Trends in Cell Biology 26 (8): 565–568. https://doi.org/10.1016/j.tcb.2016.05.002.

Article Google Scholar

Hauskeller, M. 2011. Forever young? Ethical Perspectives : An International Journal of Bioethics 18 (3): 385–405. https://doi.org/10.2143/EP.18.3.2131128.

Article Google Scholar

Hood, L., and N. Price. 2023. The age of scientific wellness: Why the future of medicine is personalized, predictive, data-rich, and in your hands. Cambridge: Harvard University Press.

Book Google Scholar

Hordijk, M., S. F. Vermeulen, and E. M. Bunnik. 2022. The ‘false hope’ argument in discussions on expanded access to investigational drugs: A critical assessment. Medicine, Health Care and Philosophy 25 (4): 693–701. https://doi.org/10.1007/s11019-022-10106-y.

Article Google Scholar

Horng, S., and C. Grady. 2003. Misunderstanding in clinical research: Distinguishing therapeutic misconception, therapeutic misestimation, & therapeutic optimism. IRB, Ethics & Human Research 25 (1): 11. https://doi.org/10.2307/3564408.

Article Google Scholar

Horvath, C. J., and M. N. Milton. 2009. The TeGenero incident and the Duff report conclusions: A series of unfortunate events or an avoidable event? Toxicologic Pathology 37 (3): 372–383. https://doi.org/10.1177/0192623309332986.

Article Google Scholar

Johnson, Rebecca A., Annette Rid, Ezekiel Emanuel, and David Wendler. 2016. Risks of phase I research with healthy participants: A systematic review. Clinical Trials 13 (2): 149–160. https://doi.org/10.1177/1740774515602868.

Jones, Jared. 2025. U and XPrize partner to revolutionize healthy aging. University of Utah, 13 May 2025. https://attheu.utah.edu/facultystaff/u-and-xprize-partner-to-revolutionize-healthy-aging/. Accessed 25 November 2025.

Juengst, Eric T. 2004. Anti-aging research and the limits of medicine. In The fountain of youth: Scientific, social and ethical perspectives on a biomedical goal, eds. S. Post and R.H. Binstock, 321–340. New York: Oxford University Press.

Juengst, Eric T., Robert H. Binstock, Maxwell Mehlman, Stephen G. Post, and Peter Whitehouse. 2003. Biogerontology, ‘anti-aging medicine,’ and the challenges of human enhancement. Hastings Center Report 33 (4): 21–30. https://doi.org/10.2307/3528377.

Justice, Jamie N. 2024. XPRIZE healthspan is a global competition to restore function. Nature Aging 4 (2): 165–166. https://doi.org/10.1038/s43587-024-00569-4.

Justice, Jamie N. 2025. XPRIZE Healthspan Qualified Teams Book 2025. XPRIZE. https://www.xprize.org/prizes/healthspan/articles/xprize-healthspan-qualified-teams-book-2025.

Kaeberlein, M. 2018. How healthy is the healthspan concept? GeroScience 40 (4): 361–364. https://doi.org/10.1007/s11357-018-0036-9.

Article Google Scholar

Kaeberlein, M. 2025. We’ll pay $101 million if you prove you can reverse aging. The Optispan Podcast, 19 November 2025. https://www.youtube.com/watch?v=1JediNaSMf4. Accessed 19 April 2026.

Kaeberlein, M., P. S. Rabinovitch, and G. M. Martin. 2015. Healthy aging: The ultimate preventative medicine. Science 350 (6265): 1191–1193. https://doi.org/10.1126/science.aad3267.

Article Google Scholar

Kennedy, Brian K., Shelley L. Berger, Anne Brunet, et al. 2014. Geroscience: Linking aging to chronic disease. Cell 159 (4): 709–713. https://doi.org/10.1016/j.cell.2014.10.039.

Kulkarni, Ameya S., Sandra Aleksic, David M. Berger, Felipe Sierra, George A. Kuchel, and Nir Barzilai. 2022. Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization. Aging Cell 21 (4) : e13596. https://doi.org/10.1111/acel.13596.

Lamkin, M., and C. Elliott. 2018. Avoiding exploitation in phase I clinical trials: More than (un)just compensation. Journal of Law, Medicine & Ethics 46 (1): 52–63. https://doi.org/10.1177/1073110518766008.

Article Google Scholar

Le Bourg, E. 2022. Geroscience: The need to address some issues. Biogerontology 23 (1): 145–150. https://doi.org/10.1007/s10522-022-09951-4.

Article Google Scholar

LeMieux, J. 2022. Blueberries and blood: Aging research goes from great science to snake oil. GEN Biotechnology 1 (1): 3–10. https://doi.org/10.1089/genbio.2022.29013.jlm.

Article Google Scholar

Linden, I. P. 2022. The case against death. Cambridge, MA: MIT Press.

MacKay, D., and K. W. Saylor. 2020. Four faces of fair subject selection. American Journal of Bioethics 20 (2): 5–19. https://doi.org/10.1080/15265161.2019.1701731.

Article Google Scholar

Masfiah, Siti, Alfarid Kurnialandi, Johannes Jacobus Meij, and Andrea Britta Maier. 2025. Definitions of healthspan: A systematic review. Ageing Research Reviews 111:102806. https://doi.org/10.1016/j.arr.2025.102806.

Masny, M. 2023. Healthspan extension, completeness of life and justice. Bioethics 37 (3): 239–245. https://doi.org/10.1111/bioe.13129.

Article Google Scholar

McKibben, B. 2004. Enough: Staying human in an engineered age. New York: Henry Holt & Co.

Miller, F., and A. Wertheimer, eds. 2009. The ethics of consent: Theory and practice. 1st ed. Oxford: Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195335149.001.0001.

Book Google Scholar

Molteni, M. 2024. Harvard longevity scientist sparks furor with claim about reversing aging in dogs. STAT News, 5 March 2024. https://www.statnews.com/2024/03/05/david-sinclair-harvard-longevity-scientist-reversing-aging-dogs. Accessed 19 April 2026.

Musschenga, B. 2019. Is there a problem with false hope? Journal of Medicine and Philosophy 44 (4): 423–441. https://doi.org/10.1093/jmp/jhz010.

Article Google Scholar

Nagai, H., E. Nakazawa, and A. Akabayashi. 2022. The creation of the Belmont Report and its effect on ethical principles: A historical study. Monash Bioethics Review 40 (2): 157–170. https://doi.org/10.1007/s40592-022-00165-5.

Article Google Scholar

National Academy of Medicine. 2022. Global roadmap for healthy longevity. Washington, D.C.: The National Academies Press.

NIH Institute on Aging. 2023. Clinical research: Benefits, risks, and safety. https://www.nia.nih.gov/health/clinical-trials-and-studies/clinical-research-benefits-risks-and-safety. Accessed 19 April 2026.

Olshansky, S.J., J.L. Kirkland, and G.M. Martin. 2015. Aging: The longevity dividend. Cold Spring Harbor: Cold Spring Harbor Laboratory Press.

Partridge, Brad, Jayne Lucke, Helen Bartlett, and Wayne Hall. 2009. Ethical, social, and personal implications of extended human lifespan identified by members of the public. Rejuvenation Research 12 (5): 351–357. https://doi.org/10.1089/rej.2009.0907.

Partridge, L., M. Fuentealba, and B. K. Kennedy. 2020. The quest to slow ageing through drug discovery. Nature Reviews Drug Discovery 19 (8): 513–532. https://doi.org/10.1038/s41573-

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