Siegel RL, Miller KD, Wagle NS et al. Cancer statistics, 2023. CA Cancer J Clin 2023;73:17–48.

PubMed  Google Scholar 

Kamisawa T, Wood LD, Itoi T et al. Pancreatic cancer. Lancet 2016;388:73–85.

Article  PubMed  CAS  Google Scholar 

Blackford AL, Canto MI, Klein AP et al. Recent trends in the incidence and survival of stage 1A pancreatic cancer: a surveillance, epidemiology, and end results analysis. J Natl Cancer Inst 2020;112:1162–1169.

Article  PubMed  PubMed Central  Google Scholar 

Klein AP. Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol 2021;18:493–502.

Article  PubMed  PubMed Central  Google Scholar 

Singhi AD, Koay EJ, Chari ST et al. Early detection of pancreatic cancer: opportunities and challenges. Gastroenterology 2019;156:2024–2040.

Article  PubMed  PubMed Central  Google Scholar 

Pereira SP, Oldfield L, Ney A et al. Early detection of pancreatic cancer. Lancet Gastroenterol Hepatol 2020;5:698–710.

Article  PubMed  PubMed Central  Google Scholar 

Nakahodo J, Kikuyama M, Nojiri S et al. Focal parenchymal atrophy of pancreas: an important sign of underlying high-grade pancreatic intraepithelial neoplasia without invasive carcinoma, i.e., carcinoma in situ. Pancreatology 2020;20:1689–1697.

Article  PubMed  CAS  Google Scholar 

Yamao K, Takenaka M, Ishikawa R et al. Partial pancreatic parenchymal atrophy is a new specific finding to diagnose small pancreatic cancer (≤10 mm) including carcinoma in situ: comparison with localized benign main pancreatic duct stenosis patients. Diagnostics (Basel) 2020;10:445.

Article  PubMed  PubMed Central  Google Scholar 

Kikuyama M, Kamisawa T, Kuruma S et al. Early diagnosis to improve the poor prognosis of pancreatic cancer. Cancers (Basel) 2018;10:48.

Article  PubMed  PubMed Central  Google Scholar 

Prokesch RW, Chow LC, Beaulieu CF et al. Isoattenuating pancreatic adenocarcinoma at multi-detector row CT: secondary signs. Radiology 2002;224:764–768.

Article  PubMed  Google Scholar 

Kim JH, Park SH, Yu ES et al. Visually isoattenuating pancreatic adenocarcinoma at dynamic-enhanced CT: frequency, clinical and pathologic characteristics, and diagnosis at imaging examinations. Radiology 2010;257:87–96.

Article  PubMed  Google Scholar 

Yoon SH, Lee JM, Cho JY et al. Small (<20 mm) pancreatic adenocarcinomas: analysis of enhancement patterns and secondary signs with multiphasic multidetector CT. Radiology 2011;259:442–452.

Article  PubMed  Google Scholar 

Ishigami K, Yoshimitsu K, Irie H et al. Diagnostic value of the delayed phase image for isoattenuating pancreatic carcinomas in the pancreatic parenchymal phase on multidetector computed tomography. Eur J Radiol 2009;69:139–146.

Article  PubMed  Google Scholar 

Fukukura Y, Kumagae Y, Fujisaki Y et al. Adding delayed phase images to dual-phase contrast-enhanced CT increases sensitivity for small pancreatic ductal adenocarcinoma. AJR Am J Roentgenol 2021;217:888–897.

Article  PubMed  Google Scholar 

Lee ES, Lee JM. Imaging diagnosis of pancreatic cancer: a state-of-the-art review. World J Gastroenterol 2014;20:7864–7877.

Article  PubMed  PubMed Central  Google Scholar 

Elbanna KY, Jang HJ, Kim TK. Imaging diagnosis and staging of pancreatic ductal adenocarcinoma: a comprehensive review. Insights Imaging 2020;11:58.

Article  PubMed  PubMed Central  Google Scholar 

Al-Hawary MM, Francis IR, Chari ST et al. Pancreatic ductal adenocarcinoma radiology reporting template: consensus statement of the society of abdominal radiology and the American pancreatic association. Gastroenterology 2014;146:291-304.e1.

Article  PubMed  Google Scholar 

Kanno A, Masamune A, Okazaki K et al. Multicenter study of early pancreatic cancer in Japan. Pancreatology 2018;18:61–67.

Article  PubMed  Google Scholar 

Hanada K, Okazaki A, Hirano N et al. Roles of ERCP in the Early Diagnosis of Pancreatic Cancer. Diagnostics (Basel) 2019;9:30.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mori T, Yamaguchi A, Kuwai T et al. Carcinoma in situ of the pancreas with fibrosis area around the carcinoma: a case report. Medicine (Baltimore) 2020;99:e22645.

Article  PubMed  PubMed Central  Google Scholar 

Kitagawa K, Mitoro A, Tomooka F et al. Diagnostic yield of liquid-based cytology in serial pancreatic juice aspiration cytological examination. DEN Open 2023;3:e177.

Article  PubMed  Google Scholar 

Nakamura S, Ishii Y, Serikawa M et al. Diagnostic ability and safety of repeated pancreatic juice cytology using an endoscopic nasopancreatic drainage catheter for pancreatic ductal adenocarcinoma: a multicenter prospective study. Diagnostics (Basel) 2023;13:2696.

Article  PubMed  PubMed Central  Google Scholar 

Ohashi Y, Iwashita T, Iwata S et al. Efficacy of serial pancreatic juice aspiration cytological examination for focal pancreatic duct stenosis: multicenter, retrospective, cohort study. Endosc Int Open 2025;13:a26556348.

PubMed  PubMed Central  Google Scholar 

Iiboshi T, Hanada K, Fukuda T, Yonehara S, Sasaki T, Chayama K. Value of cytodiagnosis using endoscopic nasopancreatic drainage for early diagnosis of pancreatic cancer: establishing a new method for the early detection of pancreatic carcinoma in situ. Pancreas 2012;41:523–529.

Article  PubMed  Google Scholar 

Mikata R, Ishihara T, Tada M et al. Clinical usefulness of repeated pancreatic juice cytology via endoscopic naso-pancreatic drainage tube in patients with pancreatic cancer. J Gastroenterol 2013;48:866–873.

Article  PubMed  Google Scholar 

Hewitt MJ, McPhail MJW, Possamai L et al. EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysis. Gastrointest Endosc 2012;75:319–331.

Article  PubMed  Google Scholar 

Ransohoff DF, Feinstein AR. Problems of spectrum and bias in evaluating the efficacy of diagnostic tests. N Engl J Med 1978;299:926–930.

Article  PubMed  CAS  Google Scholar 

Begg CB, Greenes RA. Assessment of diagnostic tests when disease verification is subject to selection bias. Biometrics 1983;39:207–215.

Article  PubMed  CAS  Google Scholar 

Bossuyt PM, Reitsma JB, Bruns DE et al. STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ 2015;351:h5527.

Article  PubMed  PubMed Central  Google Scholar 

Whiting PF, Rutjes AWS, Westwood ME et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 2011;155:529–536.

Article  PubMed  Google Scholar 

Leeflang MMG, Rutjes AWS, Reitsma JB, Hooft L, Bossuyt PMM. Variation of a test’s sensitivity and specificity with disease prevalence. CMAJ 2013;185:E537–E544.

Article  PubMed  PubMed Central  Google Scholar 

US Preventive Services Task Force, Owens DK, Davidson KW, et al. Screening for pancreatic cancer: US Preventive Services Task Force reaffirmation recommendation statement. JAMA 2019. 322: 438–444.

Goggins M, Overbeek KA, Brand R et al. Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium. Gut 2020;69:7–17.

Article  PubMed  CAS  Google Scholar 

Aslanian HR, Lee JH, Canto MI. AGA clinical practice update on pancreas cancer screening in high-risk individuals: expert review. Gastroenterology 2020;159:358–362.

Article  PubMed  CAS