We thank the patients for their cooperation in this work. We thank Asuka Toshida, Akiko Abe, Misako Ishihara, and Mizuki Takenonaka from the Genomic Medicine Center in Hiroshima University Hospital for fruitful discussions on this study. This work is supported by cooperation from all of the cooperative hospitals including Hiroshima Prefectural Hospital, NHO Kure Medical Center and Chugoku Cancer Center, Hiroshima City North Medical Center Asa Citizens Hospital, JA Onomichi General Hospital, NHO Higashihiroshima Medical Center, JA Hiroshima General Hospital, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Miyoshi Central Hospital, Kagawa University Hospital, Takamatsu Red Cross Hospital, Yamaguchi University Hospital, and Shimane University Hospital. This study was funded by a Hiroshima University subsidy for the Genomic Medicine Center and JSPS KAKENHI Grant Number JP26K18769. The funder played no role in study design, data collection, analysis and interpretation of data, or the writing of this manuscript.