Influence of endplate degeneration on fusion process in lateral lumbar interbody fusion

Sono T, Shima K, Shimizu T, Murata K, Matsuda S, Otsuki B (2024) Regenerative therapies for lumbar degenerative disc diseases: a literature review. Front Bioeng Biotechnol 12:1417600. https://doi.org/10.3389/fbioe.2024.1417600

Article  PubMed  PubMed Central  Google Scholar 

Ding S, Chen L, Fu C, Liu M, Yuan Y, BattiÉ MC, Wang Y (2024) Lumbar foraminal stenosis was associated with back pain and leg pain: epidemiological evidence from a population-based cohort. Neuroradiology 66:1649–1656. https://doi.org/10.1007/s00234-024-03391-2

Article  PubMed  Google Scholar 

Lykissas MG (2013) Current concepts on spinal arthrodesis in degenerative disorders of the lumbar spine. World J Clin Cases 1:4. https://doi.org/10.12998/wjcc.v1.i1.4

Article  PubMed  PubMed Central  Google Scholar 

Rathbone J, Rackham M, Nielsen D, Lee SM, Hing W, Riar S, Scott-Young M (2023) A systematic review of anterior lumbar interbody fusion (ALIF) versus posterior lumbar interbody fusion (PLIF), transforaminal lumbar interbody fusion (TLIF), posterolateral lumbar fusion (PLF). Eur Spine J 32:1911–26. https://doi.org/10.1007/s00586-023-07567-x

Article  PubMed  Google Scholar 

Fogel GR, Rosen L, Koltsov JCB, Cheng I (2018) Neurologic adverse event avoidance in lateral lumbar interbody fusion: technical considerations using muscle relaxants. J Spine Surg 4:247–253. https://doi.org/10.21037/jss.2018.06.01

Article  PubMed  PubMed Central  Google Scholar 

Boonsirikamchai W, Wilartratsami S, Ruangchainikom M, Korwutthikulrangsri E, Tongsai S, Luksanapruksa P (2024) Pseudarthrosis risk factors in lumbar fusion: a systematic review and meta-analysis. BMC Musculoskelet Disord 25:10.1186/s12891-024-07531-w

Article  Google Scholar 

Shahzad H, Ahmad M, Singh VK, Bhatti N, Yu E, Phillips FM, Khan SN (2024) Predictive factors of symptomatic lumbar pseudoarthrosis following multilevel primary lumbar fusion. North American Spine Society Journal (NASSJ). https://doi.org/10.1016/j.xnsj.2023.100302

Article  PubMed  Google Scholar 

Chen R, Zou K, Liu J, Li K, Zhou Y, Huang H, Yang F (2024) Do modic changes affect the fusion rate in spinal interbody fusion surgery? A systematic review and network meta-analysis. J Clin Neurosci 125:110–9. https://doi.org/10.1016/j.jocn.2024.05.019

Article  PubMed  Google Scholar 

Li H, Chen S, Wei H-Y, Han C-Y, Zeng F-Y, Yuan S-S, Qin H-Y, Yang J-S (2021) Type 2 sclerotic modic change affect fusion result in patients undergoing PLIF with pedicle screw instrumentation: a retrospective study. BMC Musculoskelet Disord. https://doi.org/10.1186/s12891-021-04461-9

Article  PubMed  PubMed Central  Google Scholar 

ErinÇ S, TalmaÇ MA, Kemah B, ÖZdemİR MH (2023) The effect of modic changes on the fusion rates of posterior interbody fusion surgery. J Neurosurg Sci. https://doi.org/10.23736/s0390-5616.21.05386-8

Article  PubMed  Google Scholar 

Lotz JC, Fields AJ, Liebenberg EC (2013) The role of the vertebral end plate in low back pain. Glob Spine J 3:153–63. https://doi.org/10.1055/s-0033-1347298

Article  CAS  Google Scholar 

Ashinsky BG, Bonnevie ED, Mandalapu SA, Pickup S, Wang C, Han L, Mauck RL, Smith HE, Gullbrand SE (2020) Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport. J Bone Miner Res 35:1572–81. https://doi.org/10.1002/jbmr.4009

Article  PubMed  PubMed Central  Google Scholar 

Chung N-S, Lee H-D, Jeon C-H (2020) The impact of vertebral end plate lesions on the radiological outcome in oblique lateral interbody fusion. Glob Spine J 11:1176–82. https://doi.org/10.1177/2192568220941447

Article  Google Scholar 

Xiao Z-f, He J-b, Su G-y, Chen M-h, Hou Y, Chen S-d, Lin D-k (2018) Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice. Arthritis Res Ther. https://doi.org/10.1186/s13075-018-1701-1

Article  PubMed  PubMed Central  Google Scholar 

Li H, Tang Y, Liu Z, Chen K, Zhang K, Hu S, Pan C, Yang H, Li B, Chen H (2024) Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling. Bone Res. https://doi.org/10.1038/s41413-024-00331-x

Article  PubMed  PubMed Central  Google Scholar 

Peng S-H, Pao J-L (2026) CT evaluation of lumbar interbody fusion: a comprehensive review with an integrated framework for principle-based interpretation. Diagnostics (Basel). https://doi.org/10.3390/diagnostics16010140

Article  PubMed  PubMed Central  Google Scholar 

Jia W (2015) Obesity in China: its characteristics, diagnostic criteria, and implications. Front Med 9:129–33. https://doi.org/10.1007/s11684-015-0387-x

Article  PubMed  Google Scholar 

Mera Y, Teraguchi M, Hashizume H, Oka H, Muraki S, Akune T, Kawaguchi H, Nakamura K, Tamai H, Tanaka S, Yoshida M, Yoshimura N, Yamada H (2020) Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study. Eur Spine J 30:1011–7. https://doi.org/10.1007/s00586-020-06618-x

Article  PubMed  Google Scholar 

Wang Z, Wang J, Jin C, Zhan X, Li Y, Xiang Q, Wang K, Ni H, Dai T, Yu Y, Xie N (2025) Development and validation of a risk prediction model for pseudarthrosis following transforaminal lumbar interbody fusion: a retrospective analysis. World Neurosurg 193:636–46. https://doi.org/10.1016/j.wneu.2024.10.021

Article  PubMed  Google Scholar 

Bekas KN, Zafeiris C (2024) The role of bone mineral density in a successful lumbar interbody fusion: a narrative review. Cureus. https://doi.org/10.7759/cureus.54727

Article  PubMed  PubMed Central  Google Scholar 

Phan K, Fadhil M, Chang N, Giang G, Gragnaniello C, Mobbs RJ (2018) Effect of smoking status on successful arthrodesis, clinical outcome, and complications after anterior lumbar interbody fusion (ALIF). World Neurosurg 110:e998–e1003. https://doi.org/10.1016/j.wneu.2017.11.157

Article  PubMed  Google Scholar 

Hsu EL, Sonn K, Kannan A, Bellary S, Yun C, Hashmi S, Nelson J, Mendoza M, Nickoli M, Ghodasra J, Park C, Mitchell S, Ashtekar A, Ghosh A, Jain A, Stock SR, Hsu WK (2015) Dioxin exposure impairs BMP-2-mediated spinal fusion in a rat arthrodesis model. J Bone Joint Surg Am 97:1003–10. https://doi.org/10.2106/jbjs.N.01311

Article  PubMed  Google Scholar 

Daffner SD, Waugh S, Norman TL, Mukherjee N, France JC (2015) Effect of serum nicotine level on posterior spinal fusion in an in vivo rabbit model. Spine J 15:1402–8. https://doi.org/10.1016/j.spinee.2015.02.041

Article  PubMed  Google Scholar 

Chin DK, Park JY, Yoon YS, Kuh SU, Jin BH, Kim KS, Cho YE (2007) Prevalence of osteoporosis in patients requiring spine surgery: incidence and significance of osteoporosis in spine disease. Osteoporos Int 18:1219–1224. https://doi.org/10.1007/s00198-007-0370-8

Article  CAS  PubMed  Google Scholar 

Filley A, Baldwin A, Ben-Natan AR, Hansen K, Arora A, Xiao A, Hammond D, Chen C, Tweedt I, Rohde J, Link T, Berven S, Sawyer A (2024) The influence of osteoporosis on mechanical complications in lumbar fusion surgery: a systematic review. North American Spine Society Journal (NASSJ). https://doi.org/10.1016/j.xnsj.2024.100327

Article  PubMed  PubMed Central  Google Scholar 

Yu Y, Robinson DL, Ackland DC, Yang Y, Lee PVS (2022) Influence of the geometric and material properties of lumbar endplate on lumbar interbody fusion failure: a systematic review. J Orthop Surg Res. https://doi.org/10.1186/s13018-022-03091-8

Article  PubMed  PubMed Central  Google Scholar 

Yang H, Chen X, Chen J, Dong Y, Huang Y, Qin L, Tan J, Yi W (2024) The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2024.1492870

Article  PubMed  PubMed Central  Google Scholar 

Mohd Isa IL, Teoh SL, Mohd Nor NH, Mokhtar SA (2022) Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration. Int J Mol Sci. https://doi.org/10.3390/ijms24010208

Article  PubMed  PubMed Central  Google Scholar 

Salman A, Khawaja AS, Baig K, Zehra U (2024) Comparing contribution of bony and cartilaginous endplate changes to intervertebral disc degeneration. Pak J Med Sci 40:10.12669/pjms.40.7.8762

Article 

Comments (0)

No login
gif