Mortz CG, Andersen KE, Dellgren C, Barington T, Bindslev-Jensen C. Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities. Allergy. 2015;70(7):836–45. https://doi.org/10.1111/all.12619. (PubMed PMID: 25832131).

Article  CAS  PubMed  Google Scholar 

Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ. Persistence of mild to moderate atopic dermatitis. JAMA Dermatol. 2014;150(6):593–600. https://doi.org/10.1001/jamadermatol.2013.10271. (PubMed PMID: 24696036; PubMed Central PMCID: PMC4352328).

Article  PubMed  PubMed Central  Google Scholar 

Sidbury R, Alikhan A, Bercovitch L, Cohen DE, Darr JM, Drucker AM, et al. Guidelines of care for the management of atopic dermatitis in adults with topical therapies. J Am Acad Dermatol. 2023;89(1):e1-20. https://doi.org/10.1016/j.jaad.2022.12.029. (PubMed PMID: 36641009).

Article  CAS  PubMed  Google Scholar 

World Health Organization. Adherence to long-term therapies : evidence for action [Internet]. World Health Organization; 2003. https://iris.who.int/handle/10665/42682. Cited 16 Aug 2025.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;29(372):n71. https://doi.org/10.1136/bmj.n71. (PubMed PMID: 33782057).

Article  Google Scholar 

JBI manual for evidence synthesis Nov 2024.

Huynh R, Wong H, Aw D, Toh M. Adherence to topical corticosteroids and moisturisers in adults with endogenous eczema in Singapore. Hong Kong J Dermatol Venereol. 2015;1(23):161–74.

Google Scholar 

Murota H, Takeuchi S, Sugaya M, Tanioka M, Onozuka D, Hagihara A, et al. Characterization of socioeconomic status of Japanese patients with atopic dermatitis showing poor medical adherence and reasons for drug discontinuation. J Dermatol Sci. 2015;79(3):279–87. https://doi.org/10.1016/j.jdermsci.2015.05.010. (PubMed PMID: 26255207).

Article  PubMed  Google Scholar 

Mollerup A, Veien NK, Johansen JD. An analysis of gender differences in patients with hand eczema—everyday exposures, severity, and consequences. Contact Dermatitis. 2014;71(1):21–30. https://doi.org/10.1111/cod.12206. (PubMed PMID: 24618009).

Article  PubMed  Google Scholar 

Starbek Zorko M, Benko M, Rakuša M, Prunk ZT. Evaluation of corticophobia in patients with atopic dermatitis and psoriasis using the TOPICOP© score. Acta Dermatovenerol Alp Pannonica Adriat. 2023;32(4):135–9 (PubMed PMID: 38126095).

PubMed  Google Scholar 

Torrelo A, Ortiz J, Alomar A, Ros S, Pedrosa E, Cuervo J. Health-related quality of life, patient satisfaction, and adherence to treatment in patients with moderate or severe atopic dermatitis on maintenance therapy: the CONDA-SAT study. Actas Dermosifiliogr. 2013;104(5):409–17. https://doi.org/10.1016/j.adengl.2013.04.004. (PubMed PMID: 23665434).

Article  CAS  PubMed  Google Scholar 

Kontzias C, Prajapati S, Feldman SR. Greater disease severity and reduced quality of life are not associated with treatment adherence in atopic patients with xerosis. J Cutan Med Surg. 2023;27(5):534–6. https://doi.org/10.1177/12034754231188435. (PubMed PMID: 37493272).

Article  CAS  PubMed  Google Scholar 

Pena-Robichaux V, Kvedar JC, Watson AJ. Text messages as a reminder aid and educational tool in adults and adolescents with atopic dermatitis: a pilot study. Dermatol Res Pract. 2010;2010:894258. https://doi.org/10.1155/2010/894258. (PubMed PMID: 20885940; PubMed Central PMCID: PMC2946611).

Article  PubMed  PubMed Central  Google Scholar 

Erdil D, Koku Aksu AE, Falay Gür T, Gürel MS. Hand eczema treatment: change behaviour with text messaging, a randomized trial. Contact Dermatitis. 2020;82(3):153–60. https://doi.org/10.1111/cod.13448. (PubMed PMID: 31794053).

Article  PubMed  Google Scholar 

Okwundu N, Cardwell LA, Cline A, Unrue EL, Richardson IM, Feldman SR. Topical corticosteroids for treatment-resistant atopic dermatitis. Cutis. 2018;102(3):205–9 (PubMed PMID: 30372711).

PubMed  Google Scholar 

Prajapati S, Kontzias C, Feldman SR. The impact accountability has on adherence to moisturizer treatment in atopic patients with xerosis. J Cutan Med Surg. 2023;27(5):538–9. https://doi.org/10.1177/12034754231188433. (PubMed PMID: 37489931).

Article  PubMed  Google Scholar 

Snyder S, Collins A, Cline A, Bashyam A, Unrue E, Feldman S, et al. Measuring and improving adherence to crisaborole 2% ointment in patients with atopic dermatitis. J Drugs Dermatol JDD. 2022;21(10):1043–8. https://doi.org/10.36849/JDD.6280. (PubMed PMID: 36219061).

Article  PubMed  Google Scholar 

Aubert-Wastiaux H, Moret L, Le Rhun A, Fontenoy AM, Nguyen JM, Leux C, et al. Topical corticosteroid phobia in atopic dermatitis: a study of its nature, origins and frequency. Br J Dermatol. 2011;165(4):808–14. https://doi.org/10.1111/j.1365-2133.2011.10449.x. (PubMed PMID: 21671892).

Article  CAS  PubMed  Google Scholar 

Kamei K, Hirose T, Yoshii N, Tanaka A. Burden of illness, medication adherence, and unmet medical needs in Japanese patients with atopic dermatitis: a retrospective analysis of a cross-sectional questionnaire survey. J Dermatol. 2021;48(10):1491–8. https://doi.org/10.1111/1346-8138.16054. (PubMed PMID: 34231235; PubMed Central PMCID: PMC9291885).

Article  PubMed  PubMed Central  Google Scholar 

Fukaya M. Why do patients with atopic dermatitis refuse to apply topical corticosteroids? Dermatol Basel Switz. 2000;201(3):242–5. https://doi.org/10.1159/000018495. (PubMed PMID: 11096196).

Article  CAS  Google Scholar 

Choi E, Tan KW, Tang F, Tan C, Chandran NS. Efficacy of targeted education in reducing topical steroid phobia: a randomized clinical trial. J Am Acad Dermatol. 2020;83(6):1681–7. https://doi.org/10.1016/j.jaad.2020.02.079. (PubMed PMID: 32171815).

Article  CAS  PubMed  Google Scholar 

Müller SM, Tomaschett D, Euler S, Vogt DR, Herzog L, Itin P. Topical corticosteroid concerns in dermatological outpatients: a cross-sectional and interventional study. Dermatol Basel Switz. 2016;232(4):444–52. https://doi.org/10.1159/000446068. (PubMed PMID: 27322385).

Article  Google Scholar 

Mollerup A, Veien NK, Johansen JD. Effectiveness of the Healthy Skin Clinic—a randomized clinical trial of nurse-led patient counselling in hand eczema. Contact Dermatitis. 2014;71(4):202–14. https://doi.org/10.1111/cod.12243. (PubMed PMID: 24766387).

Article  PubMed  Google Scholar 

Corti MAM, Stirnimann R, Borradori L, Simon D. Effects of systematic patient education in skin care and protection in a hand eczema clinic. Dermatol Basel Switz. 2014;228(3):220–4. https://doi.org/10.1159/000357523. (PubMed PMID: 24776632).

Article  Google Scholar 

Yentzer BA, Ade RA, Fountain JM, Clark AR, Taylor SL, Borgerding E, et al. Improvement in treatment adherence with a 3-day course of fluocinonide cream 0.1% for atopic dermatitis. Cutis. 2010;86(4):208–13 (PubMed PMID: 21140931).

PubMed  Google Scholar 

Hix E, Gustafson CJ, O’Neill JL, Huang K, Sandoval LF, Harrison J, et al. Adherence to a five day treatment course of topical fluocinonide 0.1% cream in atopic dermatitis. Dermatol Online J. 2013;19(10):20029 (PubMed PMID: 24139369).

Article  PubMed  Google Scholar 

Wilson R, Camacho F, Clark AR, Young T, Inabinet R, Yentzer BA, et al. Adherence to topical hydrocortisone 17-butyrate 0.1% in different vehicles in adults with atopic dermatitis. J Am Acad Dermatol. 2009;60(1):166–8. https://doi.org/10.1016/j.jaad.2008.09.031.

Article  PubMed  Google Scholar 

Gregersen DM, Peckruhn M, Breternitz-Gruhne M, Schiller I, Schumacher U, Franke L, et al. Cream versus ointment: randomized single-blinded study on the adherence to treatment with topical methylprednisolone aceponate. Contact Dermatitis. 2024;90(2):161–8. https://doi.org/10.1111/cod.14447. (PubMed PMID: 37960922).

Article  CAS  PubMed  Google Scholar 

Ervin C, Crawford R, Evans E, Feldman SR, Zeichner J, Zielinski MA, et al. Patient and caregiver preferences on treatment attributes for atopic dermatitis. J Dermatol Treat. 2022;33(4):2225–33. https://doi.org/10.1080/09546634.2021.1940810. (PubMed PMID: 34264145).

Article  Google Scholar 

Myers K, Silverberg JI, Parasuraman S, Pierce A, Eichenfield LF, Poulos C. Treatment preferences among patients with mild-to-moderate atopic dermatitis. J Dermatol Treat. 2023;34(1):2215356. https://doi.org/10.1080/09546634.2023.2215356. (PubMed PMID: 37259544).

Article  Google Scholar 

Yang MY, Jin H, Shim WH, Kim GW, Kim HS, Ko HC, et al. High rates of secondary non-adherence causes decreased efficacy of 0.1% topical tacrolimus in adult eczema patients: results from a multicenter clinical trial. J Dermatol Treat. 2018;29(2):129–34. https://doi.org/10.1080/09546634.2017.1350256.

Article  CAS  Google Scholar 

Jeziorkowska R, Sysa-Jędrzejowska A, Samochocki Z. Topical steroid therapy in atopic dermatitis in theory and practice. Postepy Dermatol Alergol. 2015;32(3):162–6. https://doi.org/10.5114/pdia.2014.40962. (PubMed PMID: 26161055; PubMed Central PMCID: PMC4495104).

Article  PubMed  PubMed Central