Continuous Infusions of IV Anesthetizing Antiseizure Medications for the Treatment of Refractory Status Epilepticus: A Critical Review

Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus–Report of the ILAE Task Force on Classification of Status Epilepticus. Epilepsia. 2015;56(10):1515–23. https://doi.org/10.1111/epi.13121. (In eng).

Article  PubMed  Google Scholar 

Vossler DG. First Seizures, Acute Repetitive, Seizures, Status Epilepticus. Continuum (Minneap Minn). 2025;31(1):Epilepsy95-124. https://doi.org/10.1212/cont.0000000000001530.

Article  Google Scholar 

Delgado-Escueta AV, Wasterlain C, Treiman DM, Porter RJ. Current concepts in neurology: management of status epilepticus. N Engl J Med. 1982;306(22):1337–40. https://doi.org/10.1056/NEJM198206033062205.

Article  CAS  PubMed  Google Scholar 

Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA. 1993;270(7):854–9. https://doi.org/10.1001/jama.1993.03510070076040.

Article  Google Scholar 

Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134:2802–18. https://doi.org/10.1093/brain/awr215. (In eng).

Article  PubMed  Google Scholar 

Marini C, Rosati A, Fusco L, et al. Genetic Etiologies of Epilepsies With Status Epilepticus: Insights From the Italian Pediatric Status Epilepticus Group Cohort. Neurology. 2026;106(8):e214791. https://doi.org/10.1212/WNL.0000000000214791.

Article  PubMed  Google Scholar 

Pang EW, Lawn ND, Lee J, Dunne JW. Mortality after a first-ever unprovoked seizure. Epilepsia. 2023;64(5):1266–77. https://doi.org/10.1111/epi.17567.

Article  PubMed  Google Scholar 

Calonge Q, Hanin A, Januel E, et al. Incidence, mortality, and management of status epilepticus from 2012 to 2022: An 11-year nationwide study. Epilepsia. 2026;67(1):213–28. https://doi.org/10.1111/epi.18627.

Article  PubMed  Google Scholar 

Calonge Q, Guinebretiere O, Nedelec T, et al. Recurrence and Mortality After a First Status Epilepticus: A Retrospective Nationwide Study From the French National Health Data System. Neurology. 2025;104(12):e213693. https://doi.org/10.1212/WNL.0000000000213693.

Article  PubMed  Google Scholar 

Trinka E, Rainer LJ, Granbichler CA, Zimmermann G, Leitinger M. Mortality, and life expectancy in Epilepsy and Status epilepticus-current trends and future aspects. Front Epidemiol. 2023;3(3):1081757. https://doi.org/10.3389/fepid.2023.1081757.

Article  PubMed  PubMed Central  Google Scholar 

Woodward MR, Armahizer MJ, Wang TI, Badjatia N, Johnson EL, Gilmore EJ. Status epilepticus in older adults: A critical review. Epilepsia. 2025;66(9):3118–37. https://doi.org/10.1111/epi.18453.

Article  PubMed  Google Scholar 

Cornwall CD, Kristensen SB, Ulvin LB, et al. Trajectories of long-term survival after status epilepticus. Epilepsia. 2025;66(8):2790–802. https://doi.org/10.1111/epi.18428.

Article  PubMed  PubMed Central  Google Scholar 

Terman SW, Guterman EL, Lin CC, Thompson MP, Burke JF. Hospital variation of outcomes in status epilepticus. Epilepsia. 2024;65(5):1415–27. https://doi.org/10.1111/epi.17927.

Article  PubMed  PubMed Central  Google Scholar 

De Stefano P, Baumann SM, Fisch U, et al. Impact of Etiology on Mortality and Recovery in Patients With Status Epilepticus. Neurology. 2026;106(5):e214624. https://doi.org/10.1212/WNL.0000000000214624.

Article  PubMed  PubMed Central  Google Scholar 

Fong MWK, Stephens E, Brockington A, et al. Status epilepticus in Auckland, New Zealand: Treatment patterns and determinants of outcome in a prospective population-based cohort. Epilepsia. 2024;65(6):1605–19. https://doi.org/10.1111/epi.17975.

Article  CAS  PubMed  Google Scholar 

Nadeem ZA, Kashif MAB, Nadeem A, et al. Temporal Trends and Regional Variations in Mortality of Adults With Status Epilepticus in the United States: A Retrospective Study From 1999 to 2020. Neurology. 2026;106(10):e214939. https://doi.org/10.1212/WNL.0000000000214939.

Article  PubMed  Google Scholar 

Glauser T, Shinnar S, Gloss D, et al. Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society. Epilepsy currents. 2016;16(1):48–61. https://doi.org/10.5698/1535-7597-16.1.48. (In eng).

Article  PubMed  PubMed Central  Google Scholar 

Gronseth GS, Cox J, Gloss D et al. Clinical Practice Guideline Process Manual. 2017 Edition ed., American Academy of Neurology, 2017.

Meierkord H, Boon P, Engelsen B, et al. EFNS guideline on the management of status epilepticus in adults. Eur J Neurol. 2010;17(3):348–55. https://doi.org/10.1111/j.1468-1331.2009.02917.x. (In eng).

Article  CAS  PubMed  Google Scholar 

Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17(1):3–23. https://doi.org/10.1007/s12028-012-9695-z. (In eng).

Article  PubMed  Google Scholar 

Silbergleit R, Durkalski V, Lowenstein D, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012;366(7):591–600. https://doi.org/10.1056/NEJMoa1107494.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001;345(9):631–7. https://doi.org/10.1056/NEJMoa002141.

Article  CAS  PubMed  Google Scholar 

Treiman DM, Meyers PD, Walton NY, et al. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med. 1998;339(12):792–8. https://doi.org/10.1056/NEJM199809173391202. (In eng).

Article  CAS  PubMed  Google Scholar 

Cruickshank M, Imamura M, Booth C, et al. Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis. Health Technol Assess. 2022;26(20):1–76. https://doi.org/10.3310/RSVK2062.

Article  PubMed  PubMed Central  Google Scholar 

Leppik IE, Derivan AT, Homan RW, Walker J, Ramsay RE, Patrick B. Double-blind study of lorazepam and diazepam in status epilepticus. JAMA. 1983;249(11):1452–4. https://doi.org/10.1001/jama.1983.03330350028021.

Article  CAS  PubMed  Google Scholar 

Walker JE, Homan RW, Vasko MR, Crawford IL, Bell RD, Tasker WG. Lorazepam in status epilepticus. Ann Neurol. 1979;6(3):207–13. https://doi.org/10.1002/ana.410060305.

Article  CAS  PubMed  Google Scholar 

Vossler DG, Gidal BE. A Summary of Antiseizure Medications Available in the United States. (https://aesnet.org/docs/default-source/pdfs-clinical/42981132_aes_summary_of_antiseizure_medications_available_in_the_united_states_4th_edition_april_2024.pdf?sfvrsn=65016203_1)

Guterman EL, Burke JF, Sporer KA. Prehospital Treatment of Status Epilepticus in the United States. JAMA. 2021;326(19):1970–1. https://doi.org/10.1001/jama.2021.15964.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guterman EL, Sanford JK, Betjemann JP, et al. Prehospital midazolam use and outcomes among patients with out-of-hospital status epilepticus. Neurology. 2020;95(24):e3203-12. https://doi.org/10.1212/WNL.0000000000010913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kellinghaus C, Rossetti AO, Trinka E, et al. Factors predicting cessation of status epilepticus in clinical practice: Data from a prospective observational registry (SENSE). Ann Neurol. 2019;85(3):421–32. https://doi.org/10.1002/ana.25416.

Article  CAS  PubMed  Google Scholar 

Sathe AG, Underwood E, Coles LD, et al. Patterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial. Epilepsia. 2021;62(3):795–806. https://doi.org/10.1111/epi.16825.

Article  CAS 

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