Hu X, Guo F. Amino acid sensing in metabolic homeostasis and health. Endocr Rev. 2021;42(1):56–76.
Chrysopoulou M, Rinschen MM. Metabolic rewiring and communication: an integrative view of kidney proximal tubule function. Annu Rev Physiol. 2024;86:405–27.
Article CAS PubMed Google Scholar
Mitrofanova A, Merscher S, Fornoni A. Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease. Nat Rev Nephrol. 2023;19(10):629–45.
Article CAS PubMed PubMed Central Google Scholar
Knol MGE, Wulfmeyer VC, Muller RU, Rinschen MM. Amino acid metabolism in kidney health and disease. Nat Rev Nephrol. 2024;20(12):771–88.
Article CAS PubMed Google Scholar
American Diabetes Association Professional Practice C. 11. Chronic kidney disease and risk management: standards of care in diabetes-2025. Diabetes Care. 2025;48(1 Suppl 1):S239-S251.
Boudonck KJ, Mitchell MW, Nemet L, Keresztes L, Nyska A, Shinar D, Rosenstock M. Discovery of metabolomics biomarkers for early detection of nephrotoxicity. Toxicol Pathol. 2009;37(3):280–92.
Article CAS PubMed Google Scholar
Naaman SC, Bakris GL. Diabetic nephropathy: update on pillars of therapy slowing progression. Diabetes Care. 2023;46(9):1574–86.
Article PubMed PubMed Central Google Scholar
Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Sci Rep. 2021;11(1):6629.
Article CAS PubMed PubMed Central Google Scholar
Dahabiyeh LA, Nimer RM, Sumaily KM, Alabdaljabar MS, Jacob M, Sabi EM, Hussein MH, Rahman AA. Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients. Sci Rep. 2023;13(1):6161.
Article CAS PubMed PubMed Central Google Scholar
Lee H, Jang HB, Yoo MG, Park SI, Lee HJ. Amino acid metabolites associated with chronic kidney disease: an eight-year follow-up Korean epidemiology study. Biomedicines. 2020. https://doi.org/10.3390/biomedicines8070222.
Article PubMed PubMed Central Google Scholar
Hocher B, Adamski J. Metabolomics for clinical use and research in chronic kidney disease. Nat Rev Nephrol. 2017;13(5):269–84.
Article CAS PubMed Google Scholar
Ghafari N, Sleno L. Challenges and recent advances in quantitative mass spectrometry-based metabolomics. Anal Sci Adv. 2024;5(5–6): e2400007.
Article PubMed PubMed Central Google Scholar
Danilova EY, Maslova AO, Stavrianidi AN, Nosyrev AE, Maltseva LD, Morozova OL. CKD urine metabolomics: modern concepts and approaches. Pathophysiology. 2023;30(4):443–66.
Article PubMed PubMed Central Google Scholar
Raptis V, Kapoulas S, Grekas D. Role of asymmetrical dimethylarginine in the progression of renal disease. Nephrology (Carlton). 2013;18(1):11–21.
Article CAS PubMed Google Scholar
Maciel LS, Marengo A, Rubiolo P, Leito I, Herodes K. Derivatization-targeted analysis of amino compounds in plant extracts in neutral loss acquisition mode by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2021;1656: 462555.
Article CAS PubMed Google Scholar
Violi JP, Bishop DP, Padula MP, Westerhausen MT, Rodgers KJ. Acetonitrile adduct analysis of underivatised amino acids offers improved sensitivity for hydrophilic interaction liquid chromatography tandem mass-spectrometry. J Chromatogr A. 2021;1655: 462530.
Article CAS PubMed Google Scholar
van de Merbel NC. Quantitative determination of endogenous compounds in biological samples using chromatographic techniques. TrAC Trends Anal Chem. 2008;27(10):924–33.
Thakare R, Chhonker YS, Gautam N, Alamoudi JA, Alnouti Y. Quantitative analysis of endogenous compounds. J Pharm Biomed Anal. 2016;128:426–37.
Article CAS PubMed Google Scholar
Visconti G, Olesti E, Gonzalez-Ruiz V, Glauser G, Tonoli D, Lescuyer P, Vuilleumier N, Rudaz S. Internal calibration as an emerging approach for endogenous analyte quantification: application to steroids. Talanta. 2022;240:123149.
Article CAS PubMed Google Scholar
FDA. Center for drug evaluation and research, bioanalytical method validation guidance for industry. 2018. https://www.fda.gov/media/70858/download. Accessed 3 Aug 2026.
Mishra S, Rajput N, Jadav T, Sahu AK, Tekade RK, Sengupta P. Advancement in analytical strategies for quantification of biomarkers with a special emphasis on surrogate approaches. Crit Rev Anal Chem. 2023;53(7):1515–30.
Article CAS PubMed Google Scholar
Nelis M, Decraecker L, Boeckxstaens G, Augustijns P, Cabooter D. Development of a HILIC-MS/MS method for the quantification of histamine and its main metabolites in human urine samples. Talanta. 2020;220: 121328.
Article CAS PubMed Google Scholar
Voegel CD, Baumgartner MR, Kraemer T, Wust S, Binz TM. Simultaneous quantification of steroid hormones and endocannabinoids (ECs) in human hair using an automated supported liquid extraction (SLE) and LC-MS/MS - insights into EC baseline values and correlation to steroid concentrations. Talanta. 2021;222: 121499.
Article CAS PubMed Google Scholar
Su M, Drotleff B, Janker T, Burger Z, Kimmig AS, Derntl B, Lammerhofer M. Quantification of endogenous steroids and hormonal contraceptives in human plasma via surrogate calibration and UHPLC-MS/MS. Anal Chem. 2025;97(25):13496–503.
Article CAS PubMed PubMed Central Google Scholar
Wang XN, Liu JQ, Shi ZQ, Sun FY, Liu LF, Xin GZ. Orthogonal label and label-free dual pretreatment for targeted profiling of neurotransmitters in enteric nervous system. Anal Chim Acta. 2020;1139:68–78.
Article CAS PubMed Google Scholar
Virgiliou C, Theodoridis G, Wilson ID, Gika HG. Quantification of endogenous aminoacids and aminoacid derivatives in urine by hydrophilic interaction liquid chromatography tandem mass spectrometry. J Chromatogr A. 2021;1642: 462005.
Article CAS PubMed Google Scholar
Yin X, Baldoni I, Adams E, Van Schepdael A. Analysis profiling of 48 endogenous amino acids and related compounds in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Molecules. 2024. https://doi.org/10.3390/molecules29245993.
Article PubMed PubMed Central Google Scholar
European Medicines Agency. Guideline on bioanalytical method validation, committee for medicinal products for human use; (EMEA/CHMP/EWP/192217/2009). Amsterdam, The Netherlands: European Medicines Agency; 2011.
Khamis MM, Adamko DJ, El-Aneed A. Strategies and challenges in method development and validation for the absolute quantification of endogenous biomarker metabolites using liquid chromatography-tandem mass spectrometry. Mass Spectrom Rev. 2021;40(1):31–52.
Article CAS PubMed Google Scholar
Uher M, Mičuda S, Kacerovský M, Hroch M. An alternative approach to validation of liquid chromatography-mass spectrometry methods for the quantification of endogenous compounds. J Chromatogr A. 2023;1705: 464173.
Article CAS PubMed Google Scholar
Zhou W, Yang S, Wang PG. Matrix effects and application of matrix effect factor. Bioanalysis. 2017;9(23):1839-44.
Duranton F, Lundin U, Gayrard N, Mischak H, Aparicio M, Mourad G, Daures JP, Weinberger KM, Argiles A. Plasma and urinary amino acid metabolomic profiling in patients with different levels of kidney function. Clin J Am Soc Nephrol. 2014;9(1):37–45.
Article CAS PubMed Google Scholar
Lin IC, Hsu CN, Lo MH, Chien SJ, Tain YL. Low urinary citrulline/arginine ratio associated with blood pressure abnormalities and arterial stiffness in childhood chronic kidney disease. J Am Soc Hypertens. 2016;10(2):115–23.
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