Zhou T, Huang W, Wang X, Zhang J, Zhou E, Tu Y, et al. Global burden of head and neck cancers from 1990 to 2019. iScience. 2024;27:109282. https://doi.org/10.1016/j.isci.2024.109282.
Article PubMed PubMed Central Google Scholar
Lalla R, Treister N, Sollecito T, Schmidt B, Patton L, Mohammadi K, et al. Oral complications at 6 months after radiation therapy for head and neck cancer. Oral Dis. 2017;23:1134–43. https://doi.org/10.1111/odi.12710.
Article CAS PubMed PubMed Central Google Scholar
Alterio D, Marvaso G, Ferrari A, Volpe S, Orecchia R, Jereczek-Fossa BA. Modern radiotherapy for head and neck cancer. Semin Oncol. 2019;46:233–45. https://doi.org/10.1053/j.seminoncol.2019.07.002.
Article CAS PubMed Google Scholar
Jansma J, Vissink A, Spijkervet FK, Roodenburg JL, Panders AK, Vermey A, et al. Protocol for the prevention and treatment of oral sequelae resulting from head and neck radiation therapy. Cancer. 1992;70:2171–80. https://doi.org/10.1002/1097-0142(19921015)70:8%3C;2171::aid-cncr2820700827%3E;3.0.co;2-s.
Article CAS PubMed Google Scholar
Silverman S. Oral cancer: complications of therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88:122–6. https://doi.org/10.1016/s1079-2104(99)70103-4.
Whitmyer CC, Waskowski JC, Iffland HA. Radiotherapy and oral sequelae: preventive and management protocols. J Dent Hyg JDH. 1997;71:23–9.
McGuire DB. Barriers and strategies in implementation of oral care standards for cancer patients. Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2003;11:435–41. https://doi.org/10.1007/s00520-003-0466-4.
Mohan R, Grosshans D. Proton therapy – present and future. Adv Drug Deliv Rev. 2017;109:26–44. https://doi.org/10.1016/j.addr.2016.11.006.
Levin WP, Kooy H, Loeffler JS, DeLaney TF. Proton beam therapy. Br J Cancer. 2005;93:849–54. https://doi.org/10.1038/sj.bjc.6602754.
Article CAS PubMed PubMed Central Google Scholar
Sherry AD, Pasalic D, Gunn GB, Fuller CD, Phan J, Rosenthal DI, et al. Proton beam therapy for head and neck carcinoma of unknown primary: toxicity and quality of life. Int J Part Ther. 2021;8:234–47. https://doi.org/10.14338/IJPT-20-00034.1.
Article PubMed PubMed Central Google Scholar
Sethi S, O’Neil M, Jensen E, Smart G, Poirier B. Toxicity with proton therapy for oral and/or oropharyngeal cancers: a scoping review. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol. 2023;52:567–74. https://doi.org/10.1111/jop.13426.
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169:467–73. https://doi.org/10.7326/M18-0850.
El Harram S, Sqalli T, Radiation-Induced, Caries. Exploring the pathway to manage the challenge. Cureus. 2025;17:e76810. https://doi.org/10.7759/cureus.76810.
Article PubMed PubMed Central Google Scholar
Kielbassa AM, Hinkelbein W, Hellwig E, Meyer-Lückel H. Radiation-related damage to dentition. Lancet Oncol. 2006;7:326–35. https://doi.org/10.1016/S1470-2045(06)70658-1.
Moore C, Markey N, Donnelly M, O’Neill C, Cardwell C, McKenna G. A prospective clinical study of the influence of dental and salivary gland radiation dose on dental caries development in patients with head and neck cancer. J Dent. 2025;159:105817. https://doi.org/10.1016/j.jdent.2025.105817.
Sroussi HY, Epstein JB, Bensadoun R, Saunders DP, Lalla RV, Migliorati CA, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6:2918–31. https://doi.org/10.1002/cam4.1221.
Article PubMed PubMed Central Google Scholar
Richards ME, Brennan MT. Chronic oral complications of oral cancer therapy. Dent Clin North Am. 2025;69:419–36. https://doi.org/10.1016/j.cden.2025.03.005.
Gupta N, Pal M, Rawat S, Grewal M, Garg H, Chauhan D, et al. Radiation-induced dental caries, prevention and treatment - A systematic review. Natl J Maxillofac Surg. 2015;6:160. https://doi.org/10.4103/0975-5950.183870.
Article PubMed PubMed Central Google Scholar
Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 1. Br Dent J. 2015;218:65–8. https://doi.org/10.1038/sj.bdj.2015.28.
Article CAS PubMed Google Scholar
Maret D, Palmier NR, Guignes P, Betancourt S, Teulières M-C, Vigarios E, et al. Consequences of hyposalivation in relation to cancer treatment and early management of radiation-induced caries: case reports. Br Dent J. 2024;237:705–9. https://doi.org/10.1038/s41415-024-7894-6.
Article PubMed PubMed Central Google Scholar
Lieshout HFJ, Bots CP. The effect of radiotherapy on dental hard tissue—a systematic review. Clin Oral Investig. 2014;18:17–24. https://doi.org/10.1007/s00784-013-1034-z.
Article CAS PubMed Google Scholar
Lu H, Zhao Q, Guo J, Zeng B, Yu X, Yu D, et al. Direct radiation-induced effects on dental hard tissue. Radiat Oncol. 2019;14:5. https://doi.org/10.1186/s13014-019-1208-1.
Article PubMed PubMed Central Google Scholar
Silva ARS, Alves FA, Antunes A, Goes MF, Lopes MA. Patterns of Demineralization and Dentin Reactions in Radiation-Related Caries. Caries Res. 2009;43:43–9. https://doi.org/10.1159/000192799.
Article CAS PubMed Google Scholar
Tu Y, Hao L, Ding Y, Zhong Y, Hua C, Jiang L. The influence of different radiotherapy doses on the mechanical properties and microstructure of the enamel and dentin of human premolar teeth. Strahlenther Onkol. 2024;200:1047–56. https://doi.org/10.1007/s00066-024-02296-6.
Chambers MS, Mellberg JR, Keene HJ, Bouwsma OJ, Garden AS, Sipos T, et al. Clinical evaluation of the intraoral fluoride releasing system in radiation-induced xerostomic subjects. Part 2: Phase I study. Oral Oncol. 2006;42:946–53. https://doi.org/10.1016/j.oraloncology.2005.12.029.
Article CAS PubMed Google Scholar
De Carvalho AJD, Paranhos LR, Oliveira MB, Novais VR. Oral care and the use of fluoride in the prevention of radiation-related caries: a scoping review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023;136:173–86. https://doi.org/10.1016/j.oooo.2023.02.007.
Epstein J. A double-blind crossover trial of Oral Balance gel and Biotene® toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol. 1999;35:132–7. https://doi.org/10.1016/S1368-8375(98)00109-2.
Article CAS PubMed Google Scholar
Gossweiler AG, Martinez Mier EA. Topical fluorides may prevent, radiation caries in adults undergoing head and neck radiotherapy. J Evid-Based Dent Pract. 2025;25:102050. https://doi.org/10.1016/j.jebdp.2024.102050.
Lee H-J, Han D-H, Kim J-H, Wu H-G. The effect of comprehensive oral care program on oral health and quality of life in patients undergoing radiotherapy for head and neck cancer: A quasi-experimental case-control study. Med (Baltim). 2021;100:e25540. https://doi.org/10.1097/MD.0000000000025540.
Luka B, Fiedler A, Ganss C, Soetedjo V, Vach K, Schlueter N. Preventing caries after radiotherapy, to the head and neck region – a systematic review. J Evid-Based Dent Pract. 2024;24:101989. https://doi.org/10.1016/j.jebdp.2024.101989.
Comments (0)