Kwak K, Akkaya M, Pierce SK. B cell signaling in context. Nat Immunol. 2019. https://doi.org/10.1038/s41590-019-0427-9.
Herzog S, Reth M, Jumaa H. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling. Nat Rev Immunol. 2009;9(3):195–205. https://doi.org/10.1038/nri2491.
Article PubMed CAS Google Scholar
Nemazee D. Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol. 2006;6(10):728–40. https://doi.org/10.1038/nri1939.
Article PubMed CAS Google Scholar
Nemazee D. Mechanisms of central tolerance for B cells. Nat Rev Immunol. 2017;17(5):281–94. https://doi.org/10.1038/nri.2017.19.
Article PubMed PubMed Central CAS Google Scholar
Tull TJ, Pitcher MJ, Guesdon W, et al. Human marginal zone B cell development from early T2 progenitors. J Exp Med. 2021;218(4):e20202001. https://doi.org/10.1084/jem.20202001.
Article PubMed PubMed Central CAS Google Scholar
Cyster JG, Allen CDC. B cell responses cell interaction dynamics and decisions. Cell. 2019. https://doi.org/10.1016/j.cell.2019.03.016.
Article PubMed PubMed Central Google Scholar
Rawlings DJ, Metzler G, Wray-Dutra M, Jackson SW. Altered B cell signalling in autoimmunity. Nat Rev Immunol. 2017;17(7):421–36. https://doi.org/10.1038/nri.2017.24.
Article PubMed PubMed Central CAS Google Scholar
Tsokos GC, Lo MS, Reis PC, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;12(12):716–30. https://doi.org/10.1038/nrrheum.2016.186.
Article PubMed CAS Google Scholar
Leffler J, Martin M, Gullstrand B, et al. Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol. 2012;188(7):3522–31. https://doi.org/10.4049/jimmunol.1102404.
Article PubMed CAS Google Scholar
Crow MK, Olferiev M, Kirou KA. Type I interferons in autoimmune disease. Annu Rev Pathol Mech Dis. 2019;14(1):369–93. https://doi.org/10.1146/annurev-pathol-020117-043952.
Giang S, La Cava A. Regulatory T cells in SLE biology and use in treatment. Curr Rheumatol Rep. 2016;18(11):67. https://doi.org/10.1007/s11926-016-0616-6.
Article PubMed CAS Google Scholar
Suárez-Fueyo A, Bradley SJ, Tsokos GC. T cells in systemic lupus erythematosus. Curr Opin Immunol. 2016;43:32–8. https://doi.org/10.1016/j.coi.2016.09.001.
Article PubMed PubMed Central CAS Google Scholar
Möckel T, Basta F, Weinmann-Menke J, Schwarting A. B cell activating factor (BAFF) structure, functions, autoimmunity and clinical implications in systemic lupus erythematosus (SLE). Autoimmun Rev. 2021;20(2):102736. https://doi.org/10.1016/j.autrev.2020.102736.
Article PubMed CAS Google Scholar
Parodis I, Rovin BH, Tektonidou MG, et al. Lupus nephritis. Nat Rev Dis Primer. 2025;11(1):69. https://doi.org/10.1038/s41572-025-00653-y.
Parodis I, Nikolopoulos D, Brylid A, Hultgren O, Alarcón-Riquelme ME, Sjöwall C. Old and new autoantibodies in systemic lupus erythematosus. Expert Rev Clin Immunol. 2026;22(1):19–29. https://doi.org/10.1080/1744666X.2026.2625964.
Article PubMed CAS Google Scholar
Hahne M, Kataoka T, Schröter M, et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998;188(6):1185–90. https://doi.org/10.1084/jem.188.6.1185.
Article PubMed PubMed Central CAS Google Scholar
Mackay F, Woodcock SA, Lawton P, et al. Mice transgenic for Baff develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999;190(11):1697–710. https://doi.org/10.1084/jem.190.11.1697.
Article PubMed PubMed Central CAS Google Scholar
Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999;189(11):1747–56. https://doi.org/10.1084/jem.189.11.1747.
Article PubMed PubMed Central CAS Google Scholar
López‐Fraga M, Fernández R, Albar JP, Hahne M. Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. EMBO Rep. 2001;2(10):945–51. https://doi.org/10.1093/embo-reports/kve198.
Article PubMed PubMed Central Google Scholar
Nardelli B, Belvedere O, Roschke V, et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood. 2001;97(1):198–204. https://doi.org/10.1182/blood.V97.1.198.
Article PubMed CAS Google Scholar
Huard B, Arlettaz L, Ambrose C, et al. BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol. 2004;16(3):467–75. https://doi.org/10.1093/intimm/dxh043.
Article PubMed CAS Google Scholar
Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T. Effect of interleukin-2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells. Cytokine. 2008;44(1):44–8. https://doi.org/10.1016/j.cyto.2008.06.005.
Article PubMed CAS Google Scholar
Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G. Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell. 2002;108(3):383–94. https://doi.org/10.1016/S0092-8674(02)00631-1.
Article PubMed CAS Google Scholar
Cachero TG, Schwartz IM, Qian F, et al. Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry. 2006;45(7):2006–13. https://doi.org/10.1021/bi051685o.
Article PubMed CAS Google Scholar
Eslami M, Schneider P. Function, occurrence and inhibition of different forms of BAFF. Curr Opin Immunol. 2021. https://doi.org/10.1016/j.coi.2021.06.009.
Thien M, Phan TG, Gardam S, et al. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity. 2004;20(6):785–98. https://doi.org/10.1016/j.immuni.2004.05.010.
Article PubMed CAS Google Scholar
Boghdadi G, Elewa EA. Increased serum APRIL differentially correlates with distinct cytokine profiles and disease activity in systemic lupus erythematosus patients. Rheumatol Int. 2014;34(9):1217–23. https://doi.org/10.1007/s00296-014-3020-4.
Article PubMed CAS Google Scholar
Sari S, Cinar S, Yalcinkaya Y, et al. The relationship between serum A proliferation-inducing ligand and B-cell activating factor levels with disease activity and organ involvement in systemic lupus erythematosus. Lupus. 2022;31(5):555–64. https://doi.org/10.1177/09612033221086123.
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