Prospective changes in sleep quality and depressive symptom burden following initiation of GLP-1-based therapies in patients with obesity: a real-world study

Młynarska E, Bojdo K, Bulicz A et al (2025) Obesity as a multifactorial chronic disease: molecular mechanisms, systemic impact, and emerging digital interventions. Curr Issues Mol Biol 47:787. https://doi.org/10.3390/cimb47100787

Article  CAS  PubMed  PubMed Central  Google Scholar 

NCD Risk Factor Collaboration (2024) Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 403:1027–1050. https://doi.org/10.1016/S0140-6736(23)02750-2

Article  Google Scholar 

Scherer PE, Hill JA (2016) Obesity, diabetes, and cardiovascular diseases: a compendium. Circ Res 118:1703–1705. https://doi.org/10.1161/CIRCRESAHA.116.308999

Article  CAS  PubMed  PubMed Central  Google Scholar 

LaGrotte C, Fernandez-Mendoza J, Calhoun SL, Liao D, Bixler EO, Vgontzas AN (2016) The relative association of obstructive sleep apnea, obesity and excessive daytime sleepiness with incident depression: a longitudinal, population-based study. Int J Obes (Lond) 40:1397–1404. https://doi.org/10.1038/ijo.2016.87

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogilvie RP, Patel SR (2017) The epidemiology of sleep and obesity. Sleep Health 3:383–388. https://doi.org/10.1016/j.sleh.2017.07.013

Article  PubMed  PubMed Central  Google Scholar 

Salvador R, Moutinho CG, Sousa C, Vinha AF, Carvalho M, Matos C (2025) Semaglutide as a GLP-1 agonist: a breakthrough in obesity treatment. Pharmaceuticals (Basel) 18:399. https://doi.org/10.3390/ph18030399

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinha R, Papamargaritis D, Sargeant JA, Davies MJ (2023) Efficacy and safety of tirzepatide in type 2 diabetes and obesity management. J Obes Metab Syndr 32:25–45. https://doi.org/10.7570/jomes22067

Article  PubMed  PubMed Central  Google Scholar 

Tuccinardi D, Masi D, Watanabe M et al (2025) Precision obesity medicine: a phenotype-guided framework for pharmacologic therapy across the lifespan. J Endocrinol Invest 48:2761–2798. https://doi.org/10.1007/s40618-025-02700-7

Article  PubMed  PubMed Central  Google Scholar 

Ciudin A, Baker JL, Belančić A et al (2026) Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO): 2026 update. Nat Med 32:1962–1966. https://doi.org/10.1038/s41591-026-04397-4

Article  CAS  PubMed  Google Scholar 

Lincoff AM, Brown-Frandsen K, Colhoun HM et al (2023) Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med 389:2221–2232. https://doi.org/10.1056/NEJMoa2307563

Article  CAS  PubMed  Google Scholar 

Chuang MH, Chen JY, Wang HY, Jiang ZH, Wu VC (2024) Clinical outcomes of tirzepatide or GLP-1 receptor agonists in individuals with type 2 diabetes. JAMA Netw Open 7:e2427258. https://doi.org/10.1001/jamanetworkopen.2024.27258

Article  PubMed  PubMed Central  Google Scholar 

Hunter K, Hölscher C (2012) Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci 13:33. https://doi.org/10.1186/1471-2202-13-33

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hölscher C (2014) The incretin hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer’s disease. Alzheimers Dement 10:S47–S54. https://doi.org/10.1016/j.jalz.2013.12.009

Article  PubMed  Google Scholar 

Anderberg RH, Richard JE, Hansson C, Nissbrandt H, Bergquist F, Skibicka KP (2016) GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality. Psychoneuroendocrinology 65:54–66. https://doi.org/10.1016/j.psyneuen.2015.11.021

Article  CAS  PubMed  Google Scholar 

Athauda D, Foltynie T (2016) The glucagon-like peptide 1 receptor as a therapeutic target in Parkinson’s disease: mechanisms of action. Drug Discov Today 21:802–818. https://doi.org/10.1016/j.drudis.2016.01.013

Article  CAS  PubMed  Google Scholar 

Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502. https://doi.org/10.1093/clinchem/18.6.499

Article  CAS  PubMed  Google Scholar 

World Health Organization (2000) Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization, Geneva

Google Scholar 

American Diabetes Association Professional Practice Committee (2025) 2. Diagnosis and classification of diabetes: Standards of Care in Diabetes—2025. Diabetes Care 48:S27–S49. https://doi.org/10.2337/dc25-S002

Article  Google Scholar 

Mach F, Koskinas KC, Roeters van Lennep JE et al (2025) 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J 46:4359–4378. https://doi.org/10.1093/eurheartj/ehaf190

Article  CAS  PubMed  Google Scholar 

Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16:606–613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sari YE, Kokoglu B, Balcioglu H, Bilge U, Colak E, Unluoglu I (2016) Turkish reliability of the Patient Health Questionnaire-9. Biomed Res India 27:S460–S462

Google Scholar 

Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K (2004) Monitoring depression treatment outcomes with the Patient Health Questionnaire-9. Med Care 42:1194–1201. https://doi.org/10.1097/00005650-200412000-00006

Article  PubMed  Google Scholar 

Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193–213. https://doi.org/10.1016/0165-1781(89)90047-4

Article  CAS  PubMed  Google Scholar 

Ağargün MY, Kara H, Anlar Ö (1996) The validity and reliability of the Pittsburgh Sleep Quality Index. Turk Psikiyatri Derg 7:107–115

Google Scholar 

Edinger JD, Arnedt JT, Bertisch SM et al (2021) Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med 17:263–298. https://doi.org/10.5664/jcsm.8988

Article  PubMed  PubMed Central  Google Scholar 

Faul F, Erdfelder E, Buchner A, Lang AG (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41:1149–1160. https://doi.org/10.3758/BRM.41.4.1149

Article  PubMed  Google Scholar 

World Obesity Federation (2024) World Obesity Atlas 2024. World Obesity Federation, London

Google Scholar 

Henney AE, Riley DR, Anson M et al (2025) Comparative efficacy of tirzepatide, liraglutide, and semaglutide in reduction of risk of major adverse cardiovascular events in patients with obstructive sleep apnea and type 2 diabetes: real-world evidence. Ann Am Thorac Soc 22:1042–1052. https://doi.org/10.1513/AnnalsATS.202409-923OC

Article  PubMed  Google Scholar 

Bajpai J, Saxena M, Agarwal U, Pradhan A (2025) Dual incretin analogue tirzepatide: SURMOUNTing the challenge of obesity-induced obstructive sleep apnea. World J Exp Med 15:109762. https://doi.org/10.5493/wjem.v15.i4.109762

Article  PubMed  PubMed Central  Google Scholar 

Carmellini P, Cuomo A, Rescalli MB, Fagiolini A (2025) GLP-1 receptor agonists in mood disorders: a psychiatric perspective. Life (Basel) 15:1422. https://doi.org/10.3390/life15091422

Article  CAS  PubMed  PubMed Central 

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