Stocchetti N, Maas AI. Traumatic intracranial hypertension. N Engl J Med. 2014;370(22):2121–30. https://doi.org/10.1056/NEJMra1208708.
Article PubMed CAS Google Scholar
Olaru C, Langberg S, McCoin NS. A review of the clinical presentation, causes, and diagnostic evaluation of increased intracranial pressure in the emergency department. West J Emerg Med. 2024;25(6):1003–10. https://doi.org/10.5811/westjem.18500.
Article PubMed PubMed Central Google Scholar
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, et al. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Med. 2012;38(11):1800–9. https://doi.org/10.1007/s00134-012-2655-4.
Godoy DA, Nunez-Patino RA, Zorrilla-Vaca A, Ziai WC, Hemphill JC 3rd. Intracranial hypertension after spontaneous intracerebral hemorrhage: a systematic review and meta-analysis of prevalence and mortality rate. Neurocrit Care. 2019;31(1):176–87. https://doi.org/10.1007/s12028-018-0658-x.
Mahto N, Owodunni OP, Okakpu U, Kazim SF, Varela S, Varela Y, et al. Postprocedural complications of external ventricular drains: a meta-analysis evaluating the absolute risk of hemorrhages, infections, and revisions. World Neurosurg. 2023;171:41–64. https://doi.org/10.1016/j.wneu.2022.11.134.
Evensen KB, Paulat K, Prieur F, Holm S, Eide PK. Utility of the tympanic membrane pressure waveform for non-invasive estimation of the intracranial pressure waveform. Sci Rep. 2018;8(1):15776. https://doi.org/10.1038/s41598-018-34083-6.
Article PubMed PubMed Central CAS Google Scholar
Doximity AI for doctors (2010), Doximity Inc, San Francisco, https://www.doximity.com/ .Accessed 15 June 2026.
511KeV (2024) File: MRI Brain T2 Axial (7).jpg. Wikimedia Commons. https://commons.wikimedia.org/wiki/File:MRI_T2_Brain_axial_image.jpg Accessed 15 June 2026.
Haggstrom, Mikael (2019) File: CT of a normal brain (thumbnail).png. Wikimedia Commons. https://commons.wikimedia.org/wiki/File:CT_of_a_normal_brain_(thumbnail).png Accessed 15 June 2026.
Gopen Q, Rosowski JJ, Merchant SN. Anatomy of the normal human cochlear aqueduct with functional implications. Hear Res. 1997;107(1–2):9–22. https://doi.org/10.1016/s0378-5955(97)00017-8.
Article PubMed CAS Google Scholar
CCFP | Cerebral Cochlear Fluid Pressure Analyser. https://www.marchbanks.co.uk/ccfp-analyser Accessed 8 Jun 2026.
Marchbanks R. MarchBanks TMD Inquiry Email. In: Mellor M, editor.2025.
Thalen EO, Wit HP, Segenhout JM, Albers FW. Dynamics of inner ear pressure change caused by intracranial pressure manipulation in the guinea pig. Acta Otolaryngol. 2001;121(4):470–6.
Article PubMed CAS Google Scholar
Olson DM, Fishel M. The use of automated pupillometry in critical care. Crit Care Nurs Clin North Am. 2016;28(1):101–7. https://doi.org/10.1016/j.cnc.2015.09.003.
Jiang J, Sari H, Goldman R, Huff E, Hanna A, Samraj R, et al. Neurological pupillary index (NPi) Measurement using pupillometry and outcomes in critically Ill children. Cureus. 2023;15(10):e46480. https://doi.org/10.7759/cureus.46480.
Article PubMed PubMed Central Google Scholar
Neuroptics. https://neuroptics.com/pupillometry-clinical-overview/ Accessed 8 Jun 2026.
Pansell J, Hack R, Rudberg P, Bell M, Cooray C. Can quantitative pupillometry be used to screen for elevated intracranial pressure? A retrospective cohort study. Neurocrit Care. 2022;37(2):531–7. https://doi.org/10.1007/s12028-022-01518-y.
Article PubMed PubMed Central Google Scholar
Robba C, Pozzebon S, Moro B, Vincent JL, Creteur J, Taccone FS. Multimodal non-invasive assessment of intracranial hypertension: an observational study. Crit Care. 2020;24(1):379. https://doi.org/10.1186/s13054-020-03105-z.
Article PubMed PubMed Central Google Scholar
Taylor WR, Chen JW, Meltzer H, Gennarelli TA, Kelbch C, Knowlton S, et al. Quantitative pupillometry, a new technology: normative data and preliminary observations in patients with acute head injury. Technical note. J Neurosurg. 2003;98(1):205–13. https://doi.org/10.3171/jns.2003.98.1.0205.
NPi-200 manual. https://neuroptics.com/wp-content/uploads/2017/02/NPi-200_Instructions.pdf Accessed 8 Jun 2026.
Stutzman S, Iype P, Marshall J, Speir K, Schneider N, Tran C, et al. Inter-device reliability of the NPi-200 and NPi-300 pupillometers. J Clin Neurosci. 2022;100:180–3. https://doi.org/10.1016/j.jocn.2022.04.023.
Hsu CH, Kuo LT. Application of pupillometry in neurocritical patients. J Pers Med. 2023. https://doi.org/10.3390/jpm13071100.
Article PubMed PubMed Central Google Scholar
Bowser M. Pupillometer Cost- DMC Email. In: Santoyo D, editor.2025.
Lussier BL, Olson DM, Aiyagari V. Automated pupillometry in neurocritical care: research and practice. Curr Neurol Neurosci Rep. 2019;19(10):71. https://doi.org/10.1007/s11910-019-0994-z.
Petrosino M, Gouvea Bogossian E, Rebora P, Galimberti S, Chesnut R, Bouzat P, et al. Neurological pupil index and intracranial hypertension in patients with acute brain injury: a secondary analysis of the ORANGE Study. JAMA Neurol. 2025;82(2):176–84. https://doi.org/10.1001/jamaneurol.2024.4189.
Article PubMed PubMed Central Google Scholar
Montgomery SP, Moore B, Hampton SM, Macy G, Li W, Bronshteyn YS. Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition. J Vis Exp. 2023(198). https://doi.org/10.3791/64929.
Berhanu D, Ferreira JC, Abegao Pinto L, Aguiar de Sousa D, Lucas Neto L, Tavares Ferreira J. The role of optic nerve sheath ultrasonography in increased intracranial pressure: a systematic review and meta analysis. J Neurol Sci. 2023;454:120853. https://doi.org/10.1016/j.jns.2023.120853.
Koziarz A, Sne N, Kegel F, Nath S, Badhiwala JH, Nassiri F, et al. Bedside optic nerve ultrasonography for diagnosing increased intracranial pressure: a systematic review and meta-analysis. Ann Intern Med. 2019;171(12):896–905. https://doi.org/10.7326/M19-0812.
Rajajee V, Fletcher JJ, Rochlen LR, Jacobs TL. Comparison of accuracy of optic nerve ultrasound for the detection of intracranial hypertension in the setting of acutely fluctuating vs stable intracranial pressure: post-hoc analysis of data from a prospective, blinded single center study. Crit Care. 2012;16(3):R79. https://doi.org/10.1186/cc11336.
Article PubMed PubMed Central Google Scholar
Purkayastha S, Sorond F. Transcranial Doppler ultrasound: technique and application. Semin Neurol. 2012;32(4):411–20. https://doi.org/10.1055/s-0032-1331812.
Rasulo FA, Calza S, Robba C, Taccone FS, Biasucci DG, Badenes R, et al. Transcranial Doppler as a screening test to exclude intracranial hypertension in brain-injured patients: the IMPRESSIT-2 prospective multicenter international study. Crit Care. 2022;26(1):110. https://doi.org/10.1186/s13054-022-03978-2.
Article PubMed PubMed Central Google Scholar
Wang Y, Duan YY, Zhou HY, Yuan LJ, Zhang L, Wang W, et al. Middle cerebral arterial flow changes on transcranial color and spectral Doppler sonography in patients with increased intracranial pressure. J Ultrasound Med. 2014;33(12):2131–6. https://doi.org/10.7863/ultra.33.12.2131.
Qu X, Wang H, Du C, Sun B. Value of transcranial color-coded duplex sonography-derived middle cerebral artery pulsatility index in intracranial pressure assessment at moderate to high altitudes. Sci Rep. 2026. https://doi.org/10.1038/s41598-026-44246-5.
Article PubMed PubMed Central Google Scholar
Rasulo FA, Bertuetti R, Robba C, Lusenti F, Cantoni A, Bernini M, et al. The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study. Crit Care. 2017;21(1):44. https://doi.org/10.1186/s13054-017-1632-2.
Article PubMed PubMed Central Google Scholar
de Moraes FM, Adissy ENB, Rocha E, Barros FCD, Freitas FGR, Miranda M, et al. Multimodal monitoring intracranial pressure by invasive and noninvasive means. Sci Rep. 2023;13(1):18404. https://doi.org/10.1038/s41598-023-45834-5.
Article PubMed PubMed Central CAS Google Scholar
Horton JC. Idiopathic intracranial hypertension. N Engl J Med. 2025;393(14):1409–19. https://doi.org/10.1056/NEJMra2404929.
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