Ghani U. Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack. Eur J Med Chem. 2015;103:133–62. https://doi.org/10.1016/j.ejmech.2015.08.043.
Article CAS PubMed Google Scholar
Alam A, Badshah G, Ayaz M, Elhenawy AA, Ahmad I, Shah SAA, Latif A, Ali L, Ali M, Ahmad M. Bis-Schiff bases as potent antidiabetic agents: Synthesis, enzyme inhibition, molecular docking and dynamic simulations. J Mol Struct. 2025;1351:144173. https://doi.org/10.1016/j.molstruc.2025.144173.
Liu R, Li L, Shao C, Cai H, Wang Z. The impact of diabetes on vascular disease: progress from the perspective of epidemics and treatments. J Diabetes Res. 2022;2022:1531289. https://doi.org/10.1155/2022/1531289.
Article CAS PubMed PubMed Central Google Scholar
Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JC, Mbanya JC. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. https://doi.org/10.1016/j.diabres.2021.109119.
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:1–22. https://doi.org/10.1038/nrdp.2015.19.
Lebovitz HE. Alpha-glucosidase inhibitors. Endocrinol Metab Clin N Am. 1997;26:539–51. https://doi.org/10.1016/S0889-8529(05)70266-8.
Shah TA, Alam A, Zainab, Assad M, Parveen Z, Rafiq H, Ayaz M, Shah SAA, Latif A, Ali M. Synthesis and Molecular Docking Study of Hydrazone Schiff Bases of α-Naphthalene‐Containing Alkyl Phenyl Ether Fragment as Potent α‐Amylase and α‐Glucosidase Inhibitors. ChemistrySelect. 2024;9:e202402297. https://doi.org/10.1002/slct.202402297.
Derosa G, Maffioli P. α-Glucosidase inhibitors and their use in clinical practice. Arch Med Sci. 2012;8:899–906. https://doi.org/10.5114/aoms.2012.31621.
Article CAS PubMed PubMed Central Google Scholar
Jabbar A, Elhenawy AA, Ayaz M, Alam A, Khan A, Shah SAA, Zghab I, Zaman K. Acylhydrazone derivatives of barbituric acid: Synthesis, in vitro α-amylase inhibition, molecular docking, ADMET and DFT analysis. Results Chem. 2025;17:102651. https://doi.org/10.1016/j.rechem.2025.102651.
Chai T-T, Kwek M-T, Ong H-C, Wong F-C. Water fraction of edible medicinal fern Stenochlaena palustris is a potent α-glucosidase inhibitor with concurrent antioxidant activity. Food Chem. 2015;186:26–31. https://doi.org/10.1016/j.foodchem.2014.12.099.
Article CAS PubMed Google Scholar
Majhi S, Das D. Chemical derivatization of natural products: Semisynthesis and pharmacological aspects-A decade update. Tetrahedron. 2021;78:131801. https://doi.org/10.1016/j.tet.2020.131801.
Hairani R, Chavasiri W. A new series of chrysin derivatives as potent non-saccharide⍺-glucosidase inhibitors. Fitoterapia. 2022;163:105301. https://doi.org/10.1016/j.fitote.2022.105301.
Article CAS PubMed Google Scholar
Nguyen DV, Hengphasatporn K, Danova A, Suroengrit A, Boonyasuppayakorn S, Fujiki R, Shigeta Y, Rungrotmongkol T, Chavasiri W. Structure—yeast α-glucosidase inhibitory activity relationship of 9-O-berberrubine carboxylates. Sci Rep. 2023;13:18865. https://doi.org/10.1038/s41598-023-45116-0.
Article CAS PubMed PubMed Central Google Scholar
Phan T-H-T, Hengphasatporn K, Shigeta Y, Xie W, Maitarad P, Rungrotmongkol T, Chavasiri W. Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives. ACS omega. 2023;8:26340–50. https://doi.org/10.1021/acsomega.3c02868.
Article CAS PubMed PubMed Central Google Scholar
Salehi B, Gültekin-Özgüven M, Kırkın C, Özçelik B, Flaviana Bezerra Morais-Braga M, Nalyda Pereira Carneiro J, Fonseca Bezerra C, Gonçalves da Silva T, Douglas Melo, Coutinho H, Amina B. Anacardium plants: chemical, nutritional composition and biotechnological applications. Biomolecules. 2019; 9: 465. https://doi.org/10.3390/biom9090465
Gandhi T, Patel M, Dholakiya BK. Studies on effect of various solvents on extraction of cashew nut shell liquid (CNSL) and isolation of major phenolic constituents from extracted CNSL. J Nat Prod Plant Resour. 2012; 2: 135–142. [Online]. Available: http://scholarsresearchlibrary.com/JNPPR-vol2-iss1/JNPPR-2012-2-1-135-142.pdf
Balasubramanyam K, Swaminathan V, Ranganathan A, Kundu TK. Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003;278:19134–40. https://doi.org/10.1074/jbc.M301580200.
Article CAS PubMed Google Scholar
Kubo I, Muroi H, Himejima M, Yamagiwa Y, Mera H, Tokushima K, Ohta S, Kamikawa T. Structure-antibacterial activity relationships of anacardic acids. J Agric Food Chem. 1993;41:1016–9. https://doi.org/10.1021/jf00030a036.
Oliveira MSC, de Morais SM, Magalhães DV, Batista WP, Vieira ÍGP, Craveiro AA, de Manezes JESA, Carvalho AFU, de Lima GPG. Antioxidant, larvicidal and antiacetylcholinesterase activities of cashew nut shell liquid constituents. Acta Trop. 2011;117:165–70. https://doi.org/10.1016/j.actatropica.2010.08.003.
Article CAS PubMed Google Scholar
Wu Y, He L, Zhang L, Chen J, Yi Z, Zhang J, Liu M, Pang X. Anacardic acid (6-pentadecylsalicylic acid) inhibits tumor angiogenesis by targeting Src/FAK/Rho GTPases signaling pathway. J Pharmacol Exp Ther. 2011;339:403–11. https://doi.org/10.1124/jpet.111.181891.
Article CAS PubMed Google Scholar
dos Santos Nascimento H, da Luz SR, do, Amaral Crispim B, Lampugnani G, Kummrow F, Barufatti A. By-Products of the Cashew Nut Production Chain as Alternatives for the Development of Larvicides: A Review. Waste and Biomass Valorization. 2024; 15: 3217–3237. https://doi.org/10.1007/s12649-023-02365-4
Toyomizu M, Sugiyama S, Jin R, Nakatsu T. α-Glucosidase and aldose reductase inhibitors: constituents of cashew, Anacardium occidentale, nut shell liquids. Phytother Res. 1993;7:252–4. https://doi.org/10.1002/ptr.2650070309.
de Souza MQ, Teotônio IMSN, de Almeida FC, Heyn GS, Alves PS, Romeiro LAS, Pratesi R, de Medeiros Nóbrega YK, Pratesi CB. Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complement Altern Med. 2018;18:1–11. https://doi.org/10.1186/s12906-018-2247-0.
Kubo I, Kinst-Hori I, Yokokawa Y. Tyrosinase inhibitors from Anacardium occidentale fruits. J Nat Prod. 1994;57:545–51. https://doi.org/10.1021/np50106a021.
Article CAS PubMed Google Scholar
Teerasripreecha D, Phuwapraisirisan P, Puthong S, Kimura K, Okuyama M, Mori H, Kimura A, Chanchao C. In vitro antiproliferative/cytotoxic activity on cancer cell lines of a cardanol and a cardol enriched from Thai Apis mellifera propolis. BMC Complement Altern Med. 2012;12:1–17. https://doi.org/10.1186/1472-6882-12-27.
Sun J, Xiao D, Lang M, Xu X. Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation. Mol Divers. 2025;29:1669–81. https://doi.org/10.1007/s11030-024-10943-4.
Article CAS PubMed Google Scholar
Ibrahim KM, Elsisi DM, Ammar YA, Araki FF, Micky JA. Sulfonylhydrazide Derivatives as Potential Anti-cancer Agents: Synthesis, In Vitro and In Silico Studies. J Protein Chem. 2024;43:949–66. https://doi.org/10.1007/s10930-024-10232-x.
Ahmad S, Abdul Qadir M, Ahmed M, Imran M, Yousaf N, Asari A, Hameed A, Muddassar M. Acetylsalicylic acid-sulfa drugs conjugates as potential urease inhibitors and anti-inflammatory agents: bio-oriented drug synthesis, molecular docking, and dynamics simulation studies. J Biomol Struct Dyn. 2024;42:9373–87. https://doi.org/10.1080/07391102.2023.2252083.
Article CAS PubMed Google Scholar
Kurşun Aktar BS. Design, synthesis, anticholinesterase and antidiabetic inhibitory activities, and molecular docking of novel fluorinated sulfonyl hydrazones. ACS omega. 2024;9:42037–48. https://doi.org/10.1021/acsomega.4c07160.
Article CAS PubMed PubMed Central Google Scholar
Dahlous KA, Ajmal M, Ullah S, Khan A, al-Rashida M, Islam T, Xianliang Z, Noreen F, Ahmed N, Al-Harrasi A. Design, synthesis, in-vitro and in-silico studies of 6-bromochromone based thiosemicarbazones as α-glucosidase inhibitors. J Mol Struct. 2025;1329:141374. https://doi.org/10.1016/j.molstruc.2025.141374.
Comments (0)