This work was supported in part by the Physician Scientist Fund at IUSM (MS) and through an award made by the National Heart, Lung, and Blood Institute of the National Institutes of Health, under the award number K23HL168362 (MS). This work was funded, in part, with support from IUSM IMPRS and the Indiana Clinical and Translational Sciences Institute funded, through an award made by the National Center for Advancing Translational Sciences of the National Institutes of Health, under the award number UL1TR00252 (BH). This work was funded, in part, with support from IUSM MPESC, through an award made by the National Heart, Lung, and Blood Institute of the National Institutes of Health, under the award number R25HL163860 (MK). Role of Funding Sources: Funding sources for this study had no role in design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.