Sood E, Newburger JW, Anixt JS, Cassidy AR, Jackson JL, Jonas RA, et al. Neurodevelopmental outcomes for individuals with congenital heart disease: updates in neuroprotection, risk-stratification, evaluation, and management: a scientific statement from the American Heart Association. Circulation. 2024;149:e997–e1022.

Article  CAS  PubMed  Google Scholar 

Ortinau CM, Smyser CD, Arthur L, Gordon EE, Heydarian HC, Wolovits J, et al. Optimizing neurodevelopmental outcomes in neonates with congenital heart disease. Pediatrics. 2022;150:e2022056415L.

Sadhwani A, Wypij D, Rofeberg V, Gholipour A, Mittleman M, Rohde J, et al. Fetal brain volume predicts neurodevelopment in congenital heart disease. Circulation. 2022;145:1108–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leon RL, Mir IN, Herrera CL, Sharma K, Spong CY, Twickler DM, et al. Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes. Pediatr Res. 2022;91:787–94.

Article  PubMed  Google Scholar 

Barker DJ, Thornburg KL, Osmond C, Kajantie E, Eriksson JG. Beyond birthweight: the maternal and placental origins of chronic disease. J Dev Orig Health Dis. 2010;1:360–4.

Article  CAS  PubMed  Google Scholar 

Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989;298:564–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton GJ, Fowden AL, Thornburg KL. Placental origins of chronic disease. Physiol Rev. 2016;96:1509–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thornburg KL, O’Tierney PF, Louey S. Review: the placenta is a programming agent for cardiovascular disease. Placenta. 2010;31:S54–9.

Article  PubMed  PubMed Central  Google Scholar 

Leon RL, Sharma K, Mir IN, Herrera CL, Brown SL, Spong CY, et al. Placental vascular malperfusion lesions in fetal congenital heart disease. Am J Obstet Gynecol. 2022;227:620.e1–e8.

Article  PubMed  Google Scholar 

Courtney J, Troja W, Owens KJ, Brockway HM, Hinton AC, Hinton RB, et al. Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries. Placenta. 2020;101:57–65.

Article  CAS  PubMed  Google Scholar 

Jones HN, Olbrych SK, Smith KL, Cnota JF, Habli M, Ramos-Gonzales O, et al. Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Placenta. 2015;36:1078–86.

Article  PubMed  PubMed Central  Google Scholar 

O’Hare CB, Mangin-Heimos KS, Gu H, Edmunds M, Bebbington M, Lee CK, et al. Placental delayed villous maturation is associated with fetal congenital heart disease. Am J Obstet Gynecol. 2023;228:231.e1–e11.

Article  PubMed  Google Scholar 

Albalawi A, Brancusi F, Askin F, Ehsanipoor R, Wang J, Burd I, et al. Placental characteristics of fetuses with congenital heart disease. J Ultrasound Med. 2017;36:965–72.

Article  PubMed  Google Scholar 

Rychik J, Goff D, McKay E, Mott A, Tian Z, Licht DJ, et al. Characterization of the placenta in the newborn with congenital heart disease: distinctions based on type of cardiac malformation. Pediatr Cardiol. 2018;39:1165–71.

Article  PubMed  PubMed Central  Google Scholar 

Ozcan T, Kikano S, Plummer S, Strainic J, Ravishankar S. The association of fetal congenital cardiac defects and placental vascular malperfusion. Pediatr Dev Pathol. 2021;24:187–92.

Article  PubMed  Google Scholar 

Mir IN, Chalak LF, Brown LS, Johnson-Welch S, Heyne R, Rosenfeld CR, et al. Impact of multiple placental pathologies on neonatal death, bronchopulmonary dysplasia, and neurodevelopmental impairment in preterm infants. Pediatr Res. 2020;87:885–91.

Article  CAS  PubMed  Google Scholar 

Redline RW, Wilson-Costello D, Borawski E, Fanaroff AA, Hack M. Placental lesions associated with neurologic impairment and cerebral palsy in very low-birth-weight infants. Arch Pathol Lab Med. 1998;122:1091–8.

CAS  PubMed  Google Scholar 

Roy B, Arbuckle S, Walker K, Morgan C, Galea C, Badawi N, et al. The role of the placenta in perinatal stroke: a systematic review. J Child Neurol. 2020;35:773–83.

Article  PubMed  Google Scholar 

Vik T, Redline R, Nelson KB, Bjellmo S, Vogt C, Ng P, et al. The placenta in neonatal encephalopathy: a case-control study. J Pediatr. 2018;202:77–85.e3.

Article  PubMed  Google Scholar 

Elbers J, Viero S, MacGregor D, DeVeber G, Moore AM. Placental pathology in neonatal stroke. Pediatrics. 2011;127:e722–9.

Article  PubMed  Google Scholar 

Schlatterer SD, Murnick J, Jacobs M, White L, Donofrio MT, Limperopoulos C. Placental pathology and neuroimaging correlates in neonates with congenital heart disease. Sci Rep. 2019;9:4137.

Article  PubMed  PubMed Central  Google Scholar 

Nijman M, van der Meeren LE, Nikkels PGJ, Stegeman R, Breur J, Jansen NJG, et al. Placental pathology contributes to impaired volumetric brain development in neonates with congenital heart disease. J Am Heart Assoc. 2024;13:e033189.

Article  PubMed  PubMed Central  Google Scholar 

Zaidi S, Brueckner M. Genetics and genomics of congenital heart disease. Circ Res. 2017;120:923–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Courtney JA, Cnota JF, Jones HN. The role of abnormal placentation in congenital heart disease: cause, correlate, or consequence? Front Physiol. 2018;9:1045.

Article  PubMed  PubMed Central  Google Scholar 

de la Pompa JL, Epstein JA. Coordinating tissue interactions: Notch signaling in cardiac development and disease. Dev Cell. 2012;22:244–54.

Article  PubMed  PubMed Central  Google Scholar 

Ronan JL, Wu W, Crabtree GR. From neural development to cognition: unexpected roles for chromatin. Nat Rev Genet. 2013;14:347–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dietrich B, Haider S, Meinhardt G, Pollheimer J, Knofler M. WNT and NOTCH signaling in human trophoblast development and differentiation. Cell Mol Life Sci. 2022;79:292.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton GJ, Jauniaux E. Development of the human placenta and fetal heart: synergic or independent? Front Physiol. 2018;9:373.

Article  PubMed  PubMed Central  Google Scholar 

Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39:1890–900.

Article  PubMed  Google Scholar 

Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, et al. Sampling and definitions of placental lesions: Amsterdam placental workshop group consensus statement. Arch Pathol Lab Med. 2016;140:698–713.

Article  PubMed  Google Scholar 

Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, et al. Brain charts for the human lifespan. Nature. 2022;604:525–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rollins CK, Ortinau CM, Stopp C, Friedman KG, Tworetzky W, Gagoski B, et al. Regional brain growth trajectories in fetuses with congenital heart disease. Ann Neurol. 2021;89:143–57.

Article  PubMed  Google Scholar 

Ajwani S,