Hardiman P, Pillay OS, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003;361(9371):1810–2. https://doi.org/10.1055/s-2007-99292.

Article  PubMed  Google Scholar 

Liu J, Wu Q, Hao Y, Jiao M, Wang X, Jiang S, Han L. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021;36(4):1108–19. https://doi.org/10.1093/humrep/deaa371.

Article  PubMed  PubMed Central  Google Scholar 

Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian J Med Res. 2019;150(4):333. https://doi.org/10.4103/ijmr.IJMR_1937_17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diamanti-Kandarakis E, Kandarakis H, Legro RS. The role of genes and environment in the etiology of PCOS. Endocrine. 2006;30:19–26. https://doi.org/10.1385/ENDO:30:1:19.

Article  CAS  PubMed  Google Scholar 

Jonard S, Dewailly D. The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest. Hum Reprod Update. 2004;10(2):107–17. https://doi.org/10.1093/HUMUPD/DMH010.

Article  PubMed  Google Scholar 

Azziz R. Polycystic ovary syndrome. Obstet Gynecol. 2018;132(2):321–36. https://doi.org/10.1097/AOG.0000000000002698.

Article  PubMed  Google Scholar 

Yilmaz B, Vellanki P, Ata B, Yildiz BO. Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil Steril. 2018;110(3):523–33. https://doi.org/10.1016/j.fertnstert.2018.04.024.

Article  PubMed  Google Scholar 

Sadeghi H, Adeli I, Calina D, Docea A, Mousavi T, Daniali M, et al. Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci. 2022;23(2):583. https://doi.org/10.3390/ijms23020583.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agarwal A, Nandipati KC, Sharma RK, Zippe CD, Raina R. Role of oxidative stress in pathophysiology of erectile dysfunction. J Androl. 2005;27:335–47. https://doi.org/10.1038/ijir.2013.49.

Article  CAS  PubMed  Google Scholar 

Coutinho EA, Kauffman AS. The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS). Med Sci. 2019;7(8):84. https://doi.org/10.3390/medsci7080084.

Article  CAS  Google Scholar 

Ullah A, Jahan S, Razak S, Pirzada M, Ullah H, Almajwal A, Rauf N, Afsar T. Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. J Ovarian Res. 2017;10:1–8. https://doi.org/10.1186/s13048-017-0359-7.

Article  CAS  Google Scholar 

Radwan RA, Abuelezz NZ, Abdelraouf SM, Bakeer EM, Abd El Rahman AA. Decreased serum level of gamma-amino butyric acid in Egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25 (OH) vitamin D levels. J Med Biochem. 2019;38(4):512. https://doi.org/10.2478/jomb-2018-0051.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marx TL, Mehta AE. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term. Cleve Clin J Med. 2003;70(1):31–45. https://doi.org/10.3949/ccjm.70.1.31.

Article  PubMed  Google Scholar 

Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N. Polycystic ovaries and herbal remedies: A systematic review. JBRA Assist Reprod. 2023;27(1):85–91. https://doi.org/10.5935/1518-0557.20220024.

Article  PubMed  PubMed Central  Google Scholar 

PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information., 2004-. PubChem Compound Summary for CID 4498, Nipecotic acid [cited 2024 Oct 18]. https://pubchem.ncbi.nlm.nih.gov/compound/Nipecotic-acid

Singh K, Kumar P, Bhatia R, Mehta V, Kumar B, Akhtar MJ. Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies. Eur J Med Chem. 2022;234:114269. https://doi.org/10.1016/j.ejmech.2022.114269.

Article  CAS  PubMed  Google Scholar 

Joseph S, Barai RS, Bhujbalrao R, Idicula-Thomas S, PCOSKB. A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome. Nucleic Acids Res. 2016;44(D1):D1032–5. https://doi.org/10.1093/nar/gkv1146.

Article  CAS  PubMed  Google Scholar 

Tian J, Chau C, Hales TG, Kaufman DL. GABAA receptors mediate inhibition of T cell responses. J Neuroimmunol. 1999;96(1):21–8. https://doi.org/10.1016/s0165-5728(98)00264-1

Article  Google Scholar 

Prajapati DP, Patel M, Dharamsi A. Beneficial effect of polyherbal formulation in letrozole induced polycystic ovarian syndrome (PCOS). J Traditional Complement Med. 2022;12(6):575–83. https://doi.org/10.1016/j.jtcme.2022.08.003.

Article  CAS  Google Scholar 

Younas A, Hussain L, Shabbir A, Asif M, Hussain M, Manzoor F. Effects of Fagonia indica on letrozole-induced polycystic ovarian syndrome (PCOS) in young adult female rats. Evidence‐Based Complement Altern Med. 2022;2022(1):1397060. https://doi.org/10.1155/2022/1397060.

Article  Google Scholar 

Gadhave PV, Sutar GV, Sajane SJ, Redasani VK, Das K, Alobid S, Almoteer AI, Rabbani SI, Yasmin F, Gilkaramenthi R, AlAnazi MA. Protective effects of vanillic acid on letrozole-induced polycystic ovarian syndrome: A comprehensive study in female wistar rats. Saudi Pharm J. 2024;32(2):101953. https://doi.org/10.1016/j.jsps.2024.101953.

Article  CAS  Google Scholar 

Ibrahim YF, Alorabi M, Abdelzaher WY, Toni ND, Thabet K, Hegazy A, Bahaa HA, Batiha GE, Welson NN, Morsy MA, Venugopala KN. Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats. Biomed Pharmacother. 2022;149:112870. https://doi.org/10.1016/j.biopha.2022.112870.

Article  CAS  PubMed  Google Scholar 

Jaw SP, Nguyen B, Vuong QT, Trinh TA, Nguyen M, Truong DD. Effects of GABA uptake inhibitors on posthypoxic myoclonus in rats. Brain Res Bull. 1996;39(3):189–92. https://doi.org/10.1016/0361-9230(95)02103-5.

Article  CAS  PubMed  Google Scholar 

Bhattamisra SK, Mohapatra L, Panda BP, Parida S. Effect of isoflavone rich soya seed extract on glucose utilization and endurance capacity in diabetic rat. 2013:42–52. https://doi.org/10.13005/BPJ/948

Mohapatra L, Bhattamishra SK, Panigrahy R, Parida S, Pati P. Antidiabetic effect of Sargassum wightii and Ulva fasciata in high fat diet and multi low dose streptozotocin induced type 2 diabetic mice. Pharm Biosci J. 2016;7:13–23. https://doi.org/10.1002/fsn3.2301

Article  CAS  Google Scholar 

Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018;21(6):645. https://doi.org/10.22038/IJBMS.2018.25778.6349.

Article  PubMed  PubMed Central  Google Scholar 

Ataabadi MS, Alaee S, Bagheri MJ, Bahmanpoor S. Role of essential oil of Mentha spicata (Spearmint) in addressing reverse hormonal and folliculogenesis disturbances in a polycystic ovarian syndrome in a rat model. Adv Pharm Bull. 2017;7(4):651. https://doi.org/10.15171/apb.2017.078.

Article  CAS  Google Scholar 

Kafali H, Iriadam M, Ozardali I, Demir N. Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease. Arch Med Res. 2004;35(2):103–8. https://doi.org/10.1016/j.arcmed.2003.10.005.

Article  CAS  PubMed  Google Scholar 

Walters KA. Role of androgens in normal and pathological ovarian function. Reproduction. 2015;149(4):R193–218. https://doi.org/10.1530/REP-14-0517.

Article  CAS  PubMed  Google Scholar 

Reyes-García MG, Hernández-Hernández F, Hernández-Téllez B, García-Tamayo F. GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6/IL-12 production. J Neuroimmunol. 2007;188(1–2):64–8. https://doi.org/10.1016/j.jneuroim.2007.05.013

Article  CAS  Google Scholar 

Solís J, Nicoll RA. Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus. Neurosci Lett. 1992;147(1):16–20. https://doi.org/10.1016/0304-3940(92)90764-x.