Qiu X, He H, Zeng H, Tong X, Zhang C, Liu Y, Liao Z, Liu Q. Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration. Genes Dis. 2024;11:101004.
Article CAS PubMed Google Scholar
Xiang S, Li J, Shen J, Zhao Y, Wu X, Li M, Yang X, Kaboli PJ, Du F, Zheng Y, Wen Q, Cho CH, Yi T, Xiao Z. Identification of prognostic genes in the tumor microenvironment of hepatocellular carcinoma. Front Immunol. 2021;12:653836.
Article CAS PubMed PubMed Central Google Scholar
Ruf B, Heinrich B, Greten TF. Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Cell Mol Immunol. 2021;18:112–27.
Article CAS PubMed Google Scholar
Bagchi S, Yuan R, Engleman EG. Immune checkpoint inhibitors for the treatment of cancer: clinical impact and mechanisms of response and resistance. Annu Rev Pathol. 2021;16:223–49.
Article CAS PubMed Google Scholar
Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS. cAMP signaling compartmentation: adenylyl cyclases as anchors of dynamic signaling complexes. Mol Pharmacol. 2018;93:270–6.
Article CAS PubMed Google Scholar
Chen R, Zeng L, Zhu S, Liu J, Zeh HJ, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D, Kang R. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis. Sci Adv. 2019;5:eaav5562.
Article CAS PubMed PubMed Central Google Scholar
Xie Y, Wu H, Hu W, Zhang H, Li A, Zhang Z, Ren S, Zhang X. Identification of hub genes of lung adenocarcinoma based on weighted gene co-expression network in Chinese population. Pathol Oncol Res. 2022;28:1610455.
Article CAS PubMed PubMed Central Google Scholar
Mao XH, Ye Q, Zhang GB, Jiang JY, Zhao HY, Shao YF, Ye ZQ, Xuan ZX, Huang P. Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer. World J Surg Oncol. 2021;19:29.
Article PubMed PubMed Central Google Scholar
Wang Q, Liu W, Zhang S, Liang Z, Jiang L, Xue A, Cen X, Bu Q. Combined transcriptomic and lipidomic analysis reveals aberrant lipid metabolism in central nervous system hemangioblastomas. Sci Rep. 2021;11:1314.
Article PubMed PubMed Central Google Scholar
Lu MY, Liu TW, Liang PC, Huang CI, Tsai YS, Tsai PC, Ko YM, Wang WH, Lin CC, Chen KY, Wang SC, Wei YJ, Hsu PY, Jang TY, Hsieh MY, Wang CW, Yeh ML, Lin ZY, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. Decision tree algorithm predicts hepatocellular carcinoma among chronic hepatitis C patients following viral eradication. Am J Cancer Res. 2023;13:190–203.
CAS PubMed PubMed Central Google Scholar
Wang S, Xiong Y, Zhao L, Gu K, Li Y, Zhao F, Li J, Wang M, Wang H, Tao Z, Wu T, Zheng Y, Li X, Liu XS. UCSCXenaShiny: an R/CRAN package for interactive analysis of UCSC Xena data. Bioinformatics. 2022;38:527–9.
Article CAS PubMed PubMed Central Google Scholar
Li C, Tang Z, Zhang W, Ye Z, Liu F. GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA. Nucleic Acids Res. 2021;49:W242–6.
Article CAS PubMed PubMed Central Google Scholar
Liu CJ, Hu FF, Xie GY, Miao YR, Li XW, Zeng Y, Guo AY. GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels. Brief Bioinform. 2023;24:1–10.
Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, Maitland A, Mostafavi S, Montojo J, Shao Q, Wright G, Bader GD, Morris Q. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010;38:W214–20.
Article CAS PubMed PubMed Central Google Scholar
Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S, Bork P, Jensen LJ, von Mering C. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:D638–46.
Article CAS PubMed PubMed Central Google Scholar
Zhang H, Liu Y, Liu J, Chen J, Wang J, Hua H, Jiang Y. cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment. J Hematol Oncol. 2024;17:5.
Article CAS PubMed PubMed Central Google Scholar
Roy D, Balasubramanian S, Krishnamurthy PT, Sola P, Rymbai E. Phosphodiesterase-4 inhibition in Parkinson’s disease: molecular insights and therapeutic potential. Cell Mol Neurobiol. 2023;43:2713–41.
Article CAS PubMed PubMed Central Google Scholar
Chung JH, Choi HJ, Kang YJ, Kim YS, Lee SY, Kwon RJ, Jeong HS, Park SJ, Jeong Y, Kang D, Ko J, Noh S, Chung HY, Moon HR, Yoon SH. MHY4571, a novel diarylcyclohexanone derivative, exerts anti-cancer activity by regulating the PKA-cAMP-response element-binding protein pathway in squamous cell lung cancer. Exp Hematol Oncol. 2022;11:68.
Article CAS PubMed PubMed Central Google Scholar
Zhang H, Kong Q, Wang J, Jiang Y, Hua H. Complex roles of cAMP-PKA-CREB signaling in cancer. Exp Hematol Oncol. 2020;9:32.
Article CAS PubMed PubMed Central Google Scholar
Pierre S, Eschenhagen T, Geisslinger G, Scholich K. Capturing adenylyl cyclases as potential drug targets. Nat Rev Drug Discov. 2009;8:321–35.
Article CAS PubMed Google Scholar
Sabbatini ME, Gorelick F, Glaser S. Adenylyl cyclases in the digestive system. Cell Signal. 2014;26:1173–81.
Article CAS PubMed PubMed Central Google Scholar
Sanchez-Collado J, Lopez JJ, Jardin I, Salido GM, Rosado JA. Cross-talk between the adenylyl cyclase/cAMP pathway and Ca(2+) homeostasis. Rev Physiol Biochem Pharmacol. 2021;179:73–116.
Article CAS PubMed Google Scholar
Wang W, Chen QY, Zhao P, Zhong J, Wang Y, Li X, Zhuo M, Chen X. Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice. Mol Pain. 2022;18:17448069221089596.
Article CAS PubMed PubMed Central Google Scholar
Johann K, Bohn T, Shahneh F, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M, Becker C. Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression. Nat Commun. 2021;12:5981.
Article CAS PubMed PubMed Central Google Scholar
Pan G, Huang M, Fu S, Wang Y, He L, Wu B, Yang J, Lin S, Fan Y. ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation. Sci Rep. 2025;15:20426.
Article PubMed PubMed Central Google Scholar
Haghshenas Z, Fathi S, Ahmadzadeh A, Nazari E. Identification of BCL11A, NTN5, and OGN as diagnosis biomarker of papillary renal cell carcinomas by bioinformatic analysis. J Kidney Cancer VHL. 2025;12:12–22.
Article PubMed PubMed Central Google Scholar
Bruno R, Poma AM, Ali G, Distefano C, Proietti A, Chella A, Lucchi M, Melfi F, Franco R, Fontanini G. Gene expression analysis of biphasic pleural mesothelioma: new potential diagnostic and prognostic markers. Diagnostics (Basel). 2022;12:1–12.
Gil GP, Ananina G, Maschietto M, Lima SCS, da Silva Costa SM, Baptista LC, Ito MT, Costa FF, Costa ML, de Melo MB. Epigenetic analysis in placentas from sickle cell disease patients reveals a hypermethylation profile. PLoS ONE 2022;17:1–23.
Fan Y, Mu J, Huang M, Imani S, Wang Y, Lin S, Fan J, Wen Q. Epigenetic identification of ADCY4 as a biomarker for breast cancer: an integrated analysis of adenylate cyclases. Epigenomics. 2019;11:1561–79.
Article CAS PubMed Google Scholar
Zhong X, Ming Z, He H, Xiong Y, Wang S, Xia Q. A highly sensitive methylation assay for prostate cancer diagnosis. World J Mens Health. 2026; 44:18–128.
Brito-Rocha T, Constancio V, Leite-Silva P, Carvalho-Maia C, Sequeira JP, Salta S, Lobo J, Machado DI, Nunes SP, Silva-Santos R, Freitas R, Goncalves Dias C, Vieira C, Soares M, Henrique R, Jeronimo C. Multi-cancer early detection via a DNA methylation multiplex ddPCR-based blood test. Int J Cancer. 2025;157:1006–19.
Comments (0)