Thornton, S. N. Sodium intake, cardiovascular disease, and physiology. Nat. Rev. Cardiol. 15, 497 (2018).

Article  PubMed  Google Scholar 

Friedman, P. A. Codependence of renal calcium and sodium transport. Annu. Rev. Physiol. 60, 179–197 (1998).

Article  CAS  PubMed  Google Scholar 

Amiry-Moghaddam, M. & Ottersen, O. P. The molecular basis of water transport in the brain. Nat. Rev. Neurosci. 4, 991–1001 (2003).

Article  CAS  PubMed  Google Scholar 

Hunter, R. W., Dhaun, N. & Bailey, M. A. The impact of excessive salt intake on human health. Nat. Rev. Nephrol. 18, 321–335 (2022).

Article  PubMed  Google Scholar 

Liang, D., Bhatta, S., Gerzanich, V. & Simard, J. M. Cytotoxic edema: mechanisms of pathological cell swelling. Neurosurg. Focus 22, E2 (2007).

Article  PubMed  PubMed Central  Google Scholar 

Rungta, R. L. et al. The cellular mechanisms of neuronal swelling underlying cytotoxic edema. Cell 161, 610–621 (2015).

Article  CAS  PubMed  Google Scholar 

Wang, Y. et al. Brain tissue sodium is a ticking clock telling time after arterial occlusion in rat focal cerebral ischemia. Stroke 31, 1386–1391 (2000).

Article  CAS  PubMed  Google Scholar 

Papadopoulos, M. C. et al. Molecular mechanisms of brain tumor edema. Neuroscience 129, 1011–1020 (2004).

Article  CAS  PubMed  Google Scholar 

Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsvetkov, P. et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375, 1254–1261 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai, Z. et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat. Cell Biol. 16, 55–65 (2014).

Article  CAS  PubMed  Google Scholar 

Boron, W. F. & Boulpaep, E. L. Medical Physiology: A Cellular and Molecular Approach 2nd edn (Saunders, 2012).

Kadir, L. A., Stacey, M. & Barrett-Jolley, R. Emerging roles of the membrane potential: action beyond the action potential. Front. Physiol. 9, 1661 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Murphy, E. & Eisner, D. A. Regulation of intracellular and mitochondrial sodium in health and disease. Circ. Res. 104, 292–303 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, J. et al. Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells. Cell Death Dis. 14, 238 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Wang, B. et al. Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute. Nat. Protoc. 14, 756–780 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grand, T. et al. 9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br. J. Pharmacol. 153, 1697–1705 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nilius, B. et al. The selectivity filter of the cation channel TRPM4. J. Biol. Chem. 280, 22899–22906 (2005).

Article  CAS  PubMed  Google Scholar 

Chen, M. & Simard, J. M. Cell swelling and a nonselective cation channel regulated by internal Ca2+ and ATP in native reactive astrocytes from adult rat brain. J. Neurosci. 21, 6512–6521 (2001).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Launay, P. et al. TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell 109, 397–407 (2002).

Article  CAS  PubMed  Google Scholar 

Bohlen, C. J. et al. A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 141, 834–845 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin King, J. V. et al. A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain. Cell 178, 1362–1374 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Autzen, H. E. et al. Structure of the human TRPM4 ion channel in a lipid nanodisc. Science 359, 228–232 (2018).

Article  CAS  PubMed  Google Scholar 

Guo, J. et al. Structures of the calcium-activated, non-selective cation channel TRPM4. Nature 552, 205–209 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nilius, B. et al. Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J. Biol. Chem. 280, 6423–6433 (2005).

Article  CAS  PubMed  Google Scholar 

Woo, S. K. et al. Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein. J. Biol. Chem. 288, 36409–36417 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, E., Liao, M., Cheng, Y. & Julius, D. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature 504, 113–118 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nilius, B. et al. Voltage dependence of the Ca2+-activated cation channel TRPM4. J. Biol. Chem. 278, 30813–30820 (2003).

Article  CAS  PubMed  Google Scholar 

Yamaguchi, S., Tanimoto, A., Otsuguro, K., Hibino, H. & Ito, S. Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity. J. Biol. Chem. 289, 35265–35282 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gerzanich, V. et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nat. Med. 15, 185–191 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan, J., Bengtson, C. P., Buchthal, B., Hagenston, A. M. & Bading, H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science 370, eaay3302 (2020).

Article  CAS  PubMed  Google Scholar 

Pironet, A., Vandewiele, F. & Vennekens, R. Exploring the role of TRPM4 in calcium-dependent triggered activity and cardiac arrhythmias. J. Physiol. 602, 1605–1621 (2024).

Article  CAS