Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019;394:64–80.

Article  PubMed  Google Scholar 

Wong KCW, Hui EP, Lo KW, Lam WKJ, Johnson D, Li L, et al. Nasopharyngeal carcinoma: an evolving paradigm. Nat Rev Clin Oncol. 2021;18:679–95.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Chen L, Hu GQ, Zhang N, Zhu XD, Yang KY, et al. Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma. New Engl J Med. 2019;381:1124–35.

Article  CAS  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.

Article  PubMed  Google Scholar 

Au KH, Ngan RKC, Ng AWY, Poon DMC, Ng WT, Yuen KT, et al. Treatment outcomes of nasopharyngeal carcinoma in modern era after intensity modulated radiotherapy (IMRT) in Hong Kong: a report of 3328 patients (HKNPCSG 1301 study). Oral Oncol. 2018;77:16–21.

Article  CAS  PubMed  Google Scholar 

Liu YP, Wen YH, Tang J, Wei Y, You R, Zhu XL, et al. Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Oncol. 2021;22:381–90.

Article  PubMed  Google Scholar 

Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, et al. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis. Lancet Oncol. 2023;24:611–23.

Article  CAS  PubMed  Google Scholar 

Tang XR, Li YQ, Liang SB, Jiang W, Liu F, Ge WX, et al. Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study. Lancet Oncol. 2018;19:382–93.

Article  CAS  PubMed  Google Scholar 

Lin DC, Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, et al. The genomic landscape of nasopharyngeal carcinoma. Nat Genet. 2014;46:866–71.

Article  CAS  PubMed  Google Scholar 

Jackman SL, Turecek J, Belinsky JE, Regehr WG. The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016;529:88–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, et al. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature. 2017;544:316–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Satterfield R, Young SM Jr., Jonas P. Triple function of synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses. Cell Rep. 2017;21:2082–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang X, Li N, Zhang J, Zhang Y, Yang X, Luo Y, et al. 5-IP(7) is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis. Nat Metab. 2021;3:1400–14.

Article  CAS  PubMed  Google Scholar 

Liu X, Li C, Yang Y, Liu X, Li R, Zhang M, et al. Synaptotagmin 7 in twist-related protein 1-mediated epithelial–mesenchymal transition of non-small cell lung cancer. EBioMedicine. 2019;46:42–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li L, Zhao S, Liu Z, Zhang N, Pang S, Liu J, et al. Sunitinib treatment promotes metastasis of drug-resistant renal cell carcinoma via TFE3 signaling pathway. Cell Death Dis. 2021;12:220.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanda M, Tanaka H, Shimizu D, Miwa T, Umeda S, Tanaka C, et al. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Oncogene. 2018;37:5355–66.

Article  CAS  PubMed  Google Scholar 

Fu Y, Tian G, Zhang Z, Yang X. SYT7 acts as an oncogene and a potential therapeutic target and was regulated by DeltaNp63alpha in HNSCC. Cancer Cell Int. 2021;21:696.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poturnajova M, Kozovska Z, Matuskova M. Aldehyde dehydrogenase 1A1 and 1A3 isoforms—mechanism of activation and regulation in cancer. Cell Signal. 2021;87:110120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamashita D, Minata M, Ibrahim AN, Yamaguchi S, Coviello V, Bernstock JD, et al. Identification of ALDH1A3 as a viable therapeutic target in breast cancer metastasis-initiating cells. Mol Cancer Ther. 2020;19:1134–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Wang HW, Wang S, Fan L, Feng S, Cai X, et al. USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells. J Clin Investig. 2019;129:2043–55.

Article  PubMed  PubMed Central  Google Scholar 

Yun X, Zhang K, Wang J, Pangeni RP, Yang L, Bonner M, et al. Targeting USP22 suppresses tumorigenicity and enhances cisplatin sensitivity through ALDH1A3 downregulation in cancer-initiating cells from lung adenocarcinoma. Mol Cancer Res. 2018;16:1161–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nie S, Qian X, Shi M, Li H, Peng C, Ding X, et al. ALDH1A3 accelerates pancreatic cancer metastasis by promoting glucose metabolism. Front Oncol. 2020;10:915.

Article  PubMed  PubMed Central  Google Scholar 

Huang X, Hou Y, Weng X, Pang W, Hou L, Liang Y, et al. Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway. Oncogenesis. 2021;10:4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan JJ, Cai J, Guo YF, Bian XW, Yu SC. ALDH1A3, a metabolic target for cancer diagnosis and therapy. Int J Cancer. 2016;139:965–75.

Article  CAS  PubMed  Google Scholar 

Ho Y, Tsao SW, Zeng M, Lui VW. STAT3 as a therapeutic target for Epstein-Barr virus (EBV): associated nasopharyngeal carcinoma. Cancer Lett. 2013;330:141–9.

Article  CAS  PubMed  Google Scholar 

Yu H, Lee H, Herrmann A, Buettner R, Jove R. Revisiting STAT3 signalling in cancer: new and unexpected biological functions. Nat Rev Cancer. 2014;14:736–46.

Article  CAS  PubMed  Google Scholar 

Cheng JZ, Chen JJ, Xue K, Wang ZG, Yu D. Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma. Cancer Cell Int. 2018;18:110.

Article  PubMed  PubMed Central  Google Scholar 

Xiao B, Li J, Fan Y, Ye M, Lv S, Xu B, et al. Downregulation of SYT7 inhibits glioblastoma growth by promoting cellular apoptosis. Mol Med Rep. 2017;16:9017–22.

Article  CAS  PubMed  Google Scholar 

Dong S, Pan J, Shen YB, Zhu LX, Chen L, Zhu F, et al. SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination. Endocr Relat Cancer. 2022;29:175–89.

Article  CAS  PubMed  Google Scholar 

Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, et al. Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc Natl Acad Sci USA. 2013;110:8644–9.