This study was supported by grants from National Key R&D Program of China (No. 2023YFC2413400), the National Natural Science Foundation of China (No. 82473086, No.82403006), Noncommunicable Chronic Diseases-National Science and Technology Major Project (2025ZD0552400, 2025ZD0552402), CAMS Innovation Fund for Medical Sciences (ClFMS, 2024-I2M-ZD-001), Beijing Natural Science Foundation (No. 7242104, No. 7244385, No. 7264329, L248053), Peking Union Medical College Hospital Talent Cultivation Program (Category D, UHB11961、UHB12423), National High Level Hospital Clinical Research Funding (2022-PUMCH-D-001, 2025-PUMCH-A-070), the Fundamental Research Funds for the Central Universities, Peking Union Medical College (No.3332025182), the Postdoctoral Fellowship Program of CPSF (GZB2024007).