Smith EMD, Lythgoe H, Midgley A, Beresford MW, Hedrich CM. Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options. Clin Immunol. 2019;209:108274. https://doi.org/10.1016/j.clim.2019.108274.

Article  CAS  PubMed  Google Scholar 

Papadopoulou C, Chew C, Wilkinson MGL, McCann L, Wedderburn LR. Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care. Nat Rev Rheumatol. 2023;19:343–62. https://doi.org/10.1038/s41584-023-00967-9.

Article  PubMed  PubMed Central  Google Scholar 

Ruperto N, Buratti S, Duarte-Salazar C, Pistorio A, Reiff A, Bernstein B, et al. Health-related quality of life in juvenile-onset systemic lupus erythematosus and its relationship to disease activity and damage. Arthritis Care Res. 2004;51:458–64. https://doi.org/10.1002/art.20412.

Article  Google Scholar 

Witczak BN, Bollerslev J, Godang K, Schwartz T, Flatø B, Molberg Ø, et al. Body composition in long-standing juvenile dermatomyositis: associations with disease activity, muscle strength and cardiometabolic measures. Rheumatology. 2022;61:2959–68. https://doi.org/10.1093/rheumatology/keab805.

Article  CAS  PubMed  Google Scholar 

Smith EMD, Egbivwie N, Jorgensen AL, Ciurtin C, Al-Abadi E, Armon K, et al. Real world treatment of juvenile-onset systemic lupus erythematosus: Data from the UK JSLE cohort study. Clin Immunol. 2022;239:109028. https://doi.org/10.1016/j.clim.2022.109028.

Article  CAS  PubMed  Google Scholar 

Costa-Reis P, Nativ S, Isgro J, Rodrigues T, Yildirim-Toruner C, Starr A, et al. Major infections in a cohort of 120 patients with juvenile-onset systemic lupus erythematosus. Clin Immunol. 2013;149:442–9. https://doi.org/10.1016/j.clim.2013.08.009.

Article  CAS  PubMed  Google Scholar 

Knight AM, Trupin L, Katz P, Yelin E, Lawson EF. Depression risk in young adults with juvenile- and adult-onset lupus: twelve years of followup. Arthritis Care Res. 2018;70:475–80. https://doi.org/10.1002/acr.23290.

Article  Google Scholar 

Beresford MW, Davidson JE. Adolescent development and SLE. Best Pract Res Clin Rheumatol. 2006;20:353–68. https://doi.org/10.1016/j.berh.2005.11.003.

Article  PubMed  Google Scholar 

Wilkinson MGL, Rosser EC. B cells as a therapeutic target in paediatric rheumatic disease. Front Immunol. 2019;10:214. https://doi.org/10.3389/fimmu.2019.00214.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Tian X, Lu X, Peng Q, Shu X, Yang H, et al. Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis. Sci Rep. 2016;6:27479. https://doi.org/10.1038/srep27479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piper CJM, Wilkinson MGL, Deakin CT, Otto GW, Dowle S, Duurland CL, et al. CD19+CD24hiCD38hi B cells are expanded in juvenile dermatomyositis and exhibit a pro-inflammatory phenotype after activation through toll-like receptor 7 and interferon-α. Front Immunol. 2018;9:1372. https://doi.org/10.3389/fimmu.2018.01372.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Syntakas AEK, Nguyen HD, Restuadi R, Jebson BR, Alexiou V, Marshall LR, et al. OA34 Unravelling the role of B cells and interferon dysregulation in juvenile dermatomyositis. Rheumatology. 2024;63:keae163-034. https://doi.org/10.1093/rheumatology/keae163.034.

Article  Google Scholar 

Furie RA, Aroca G, Cascino MD, Garg JP, Rovin BH, Alvarez A, et al. B-cell depletion with obinutuzumab for the treatment of proliferative lupus nephritis: a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 2022;81:100–7. https://doi.org/10.1136/annrheumdis-2021-220920.

Article  CAS  PubMed  Google Scholar 

Aggarwal R, Bandos A, Reed AM, Ascherman DP, Barohn RJ, Feldman BM, et al. Predictors of clinical improvement in rituximab-treated refractory adult and juvenile dermatomyositis and adult polymyositis. Arthritis Rheumatol. 2014;66:740–9. https://doi.org/10.1002/art.38270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mysler EF, Spindler AJ, Guzman R, Bijl M, Jayne D, Furie RA, et al. Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double-blind, Phase III Study. Arthritis Rheum. 2013;65:2368–79. https://doi.org/10.1002/art.38037.

Article  CAS  PubMed  Google Scholar 

Mei HE, Schmidt S, Dörner T. Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity. Arthritis Res Ther. 2012;14:S1. https://doi.org/10.1186/ar3909.

Article  PubMed  PubMed Central  Google Scholar 

Montalvo MJ, Bandey IN, Rezvan A, Wu K-L, Saeedi A, Kulkarni R, et al. Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition. Cell Death Dis. 2024;15:1–14. https://doi.org/10.1038/s41419-024-06461-8.

Article  CAS  Google Scholar 

Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 2018;378:439–48. https://doi.org/10.1056/NEJMoa1709866.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, et al. CD19 CAR T-cell therapy in autoimmune disease — a case series with follow-up. N Engl J Med. 2024;390:687–700. https://doi.org/10.1056/NEJMoa2308917.

Article  PubMed  Google Scholar 

Taubmann J, Knitza J, Müller F, Völkl S, Aigner M, Kleyer A, et al. Rescue therapy of antisynthetase syndrome with CD19-targeted CAR-T cells after failure of several B-cell depleting antibodies. Rheumatology. 2024;63:e12–4. https://doi.org/10.1093/rheumatology/kead330.

Article  PubMed  Google Scholar 

Müller F, Boeltz S, Knitza J, Aigner M, Völkl S, Kharboutli S, et al. CD19-targeted CAR T cells in refractory antisynthetase syndrome. Lancet. 2023;401:815–8. https://doi.org/10.1016/S0140-6736(23)00023-5.

Article  PubMed  Google Scholar 

Krickau T, Naumann-Bartsch N, Aigner M, Kharboutli S, Kretschmann S, Spoerl S, et al. CAR T-cell therapy rescues adolescent with rapidly progressive lupus nephritis from haemodialysis. Lancet. 2024;403:1627–30. https://doi.org/10.1016/S0140-6736(24)00424-0.

Article  CAS  PubMed  Google Scholar 

Marasco E, Bracaglia C, Merli P, Alvarez PM, Nicolai R, Algeri M, et al. P101 Anti-CD19 CAR-T cell therapy for refractory childhood-onset systemic lupus erythematosus. Poster Present., Lupus Foundation of America; 2024, p. A113.1-A113. https://doi.org/10.1136/lupus-2024-el.155.

Nicolai R, Merli P, Moran Alvarez P, Bracaglia C, Del Bufalo F, Marasco E, et al. Autologous CD19‐ targeting CAR T cells in refractory juvenile dermatomyositis. Arthritis Rheumatol 2024:art.42933. https://doi.org/10.1002/art.42933.

Tucker LB, Menon S, Schaller JG, Isenberg DA. Adult- and childhood-onset systemic lupus erythematosus: a comparison of onset, clinical features, serology, and outcome. Rheumatology. 1995;34:866–72. https://doi.org/10.1093/rheumatology/34.9.866.

Article  CAS  Google Scholar 

Bader-Meunier B, Armengaud JB, Haddad E, Salomon R, Deschênes G, Koné-Paut I, et al. Initial presentation of childhood-onset systemic lupus erythematosus: a French multicenter study. J Pediatr. 2005;146:648–53. https://doi.org/10.1016/j.jpeds.2004.12.045.

Article  CAS  PubMed  Google Scholar 

Charras A. Systemic lupus erythematosus in children and young people. Curr Rheumatol Rep. 2021;23:1–5.

Article  Google Scholar 

Palafox-Flores JG. Systemic lupus erythematosus in pediatric patients: Pulmonary manifestations. Respir Med. 2023;220:107456.

Article  PubMed  Google Scholar 

Labouret M, Costi S, Bondet V, Trebossen V, Le Roux E, Ntorkou A, et al. Juvenile neuropsychiatric systemic lupus erythematosus: identification of novel central neuroinflammation biomarkers. J Clin Immunol. 2023;43:615–24. https://doi.org/10.1007/s10875-022-01407-1.

Article  CAS  PubMed  Google Scholar 

Quilter M, Hiraki L, Korczak D. Depressive and anxiety symptom prevalence in childhood-onset systemic lupus erythematosus: a systematic review. Lupus. 2019;28:878–87. https://doi.org/10.1177/0961203319853621.

Article  CAS  PubMed