K. G J BL, L B, D. C M E, A M, C MM (2021) The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy. Eur J Endocrinol 185. https://doi.org/10.1530/eje-21-0479
Leo M, Menconi F, Rocchi R, Latrofa F, Sisti E, Profilo MA, Mazzi B, Albano E, Nardi M, Vitti P, Marcocci C, Marinò M (2015) Role of the underlying thyroid disease on the phenotype of graves’ orbitopathy in a tertiary referral center. Thyroid 25:347–351. https://doi.org/10.1089/thy.2014.0475
Taylor PN, Zhang L, Lee RWJ, Muller I, Ezra DG, Dayan CM, Kahaly GJ, Ludgate M (2020) New insights into the pathogenesis and nonsurgical management of graves orbitopathy. Nat Rev Endocrinol 16:104–116. https://doi.org/10.1038/s41574-019-0305-4
Article CAS PubMed Google Scholar
Lee ACH, Kahaly GJ (2025) Targeted immunotherapies for graves’ thyroidal & orbital diseases. Front Immunol 16:1571427. https://doi.org/10.3389/fimmu.2025.1571427
Article CAS PubMed PubMed Central Google Scholar
Gong B, Meng F, Wang X, Han Y, Yang W, Wang C, Shan Z (2024) Effects of iodine intake on gut microbiota and gut metabolites in Hashimoto thyroiditis-diseased humans and mice. Commun Biol 7:136. https://doi.org/10.1038/s42003-024-05813-6
Article CAS PubMed PubMed Central Google Scholar
Virili C, Stramazzo I, Bagaglini MF, Carretti AL, Capriello S, Romanelli F, Trimboli P, Centanni M (2024) The relationship between thyroid and human-associated microbiota: A systematic review of reviews. Rev Endocr Metab Disord 25:215–237. https://doi.org/10.1007/s11154-023-09839-9
Shi TT, Xin Z, Hua L, Zhao RX, Yang YL, Wang H, Zhang S, Liu W, Xie RR (2019) Alterations in the intestinal microbiota of patients with severe and active graves’ orbitopathy: a cross-sectional study. J Endocrinol Invest 42:967–978. https://doi.org/10.1007/s40618-019-1010-9
Article CAS PubMed Google Scholar
Xue C, Li G, Zheng Q, Gu X, Shi Q, Su Y, Chu Q, Yuan X, Bao Z, Lu J, Li L (2023) Tryptophan metabolism in health and disease. Cell Metab 35:1304–1326. https://doi.org/10.1016/j.cmet.2023.06.004
Article CAS PubMed Google Scholar
Seo SK, Kwon B (2023) Immune regulation through Tryptophan metabolism. Exp Mol Med 55:1371–1379. https://doi.org/10.1038/s12276-023-01028-7
Article CAS PubMed PubMed Central Google Scholar
Xue C, Li G, Zheng Q, Gu X, Shi Q, Su Y, Chu Q, Yuan X, Bao Z, Lu J, Li L (2023) Tryptophan metabolism in health and disease. Cell Metabol 35:1304–1326. https://doi.org/10.1016/j.cmet.2023.06.004
Roager HM, Licht TR (2018) Microbial Tryptophan catabolites in health and disease. Nat Commun 9:3294. https://doi.org/10.1038/s41467-018-05470-4
Article CAS PubMed PubMed Central Google Scholar
Scott SA, Fu J, Chang PV (2020) Microbial Tryptophan metabolites regulate gut barrier function via the Aryl hydrocarbon receptor. Proc Natl Acad Sci U S A 117:19376–19387. https://doi.org/10.1073/pnas.2000047117
Article CAS PubMed PubMed Central Google Scholar
Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336:1268–1273. https://doi.org/10.1126/science.1223490
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Xiao-Feng F, Qin B, Huang (2018) Tumor-Repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation. Cancer Cell 33:480–494e487. https://doi.org/10.1016/j.ccell.2018.02.005
Piper CJM, Rosser EC, Oleinika K, Nistala K, Krausgruber T, Rendeiro AF, Banos A, Drozdov I, Villa M, Thomson S, Xanthou G, Bock C, Stockinger B, Mauri C, Cells B (2019) Cell Rep 29:1878–1892e1877. https://doi.org/10.1016/j.celrep.2019.10.018
Cervantes-Barragan L, Chai JN, Tianero MD, Di Luccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M (2017) Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8αα(+) T cells. Science 357:806–810. https://doi.org/10.1126/science.aah5825
Article CAS PubMed PubMed Central Google Scholar
Łacheta D, Miśkiewicz P, Głuszko A, Nowicka G, Struga M, Kantor I, Poślednik KB, Mirza S, Szczepański MJ (2019) Immunological Aspects of Graves’ Ophthalmopathy, Biomed Res Int, (2019) 7453260. https://doi.org/10.1155/2019/7453260
Bartalena L, Piantanida E, Gallo D, Lai A, Tanda ML, Epidemiology N, History (2020) Risk factors, and prevention of graves’ orbitopathy. Front Endocrinol (Lausanne) 11:615993. https://doi.org/10.3389/fendo.2020.615993
Görtz G-E, Philipp S, Bruderek K, Jesenek C, Horstmann M, Henning Y, Oeverhaus M, Daser A, Bechrakis NE, Eckstein A, Brandau S, Berchner-Pfannschmidt U (2023) Macrophage-Orbital fibroblast interaction and hypoxia promote inflammation and adipogenesis in graves’ orbitopathy. Endocrinology 164. https://doi.org/10.1210/endocr/bqac203
Subekti I, Pramono LA (2018) Current diagnosis and management of graves’ disease. Acta Med Indones 50:177–182
Hoang TD, Stocker DJ, Chou EL, Burch HB (2022) Update on clinical management of graves disease and thyroid eye disease. Endocrinol Metab Clin North Am 51(2022):287–304. https://doi.org/10.1016/j.ecl.2021.12.004
Article PubMed PubMed Central Google Scholar
Park M, Kim JY, Kang JM, Lee HJ, Banga JP, Kim GJ, Lew H (2021) PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Res Ther 12. https://doi.org/10.1186/s13287-021-02337-2
Yang W, Pan Q, Li Q, Zhou S, Cao X (2025) A simple, reliable and easily generalizable cell-based assay for screening potential drugs that inhibit lipid accumulation. Curr Res Toxicol 8:100213. https://doi.org/10.1016/j.crtox.2024.100213
Article CAS PubMed Google Scholar
Yang W, Wang J, Chen Z, Chen J, Meng Y, Chen L, Chang Y, Geng B, Sun L, Dou L, Li J, Guan Y, Cui Q, Yang J (2017) NFE2 induces miR-423-5p to promote gluconeogenesis and hyperglycemia by repressing the hepatic FAM3A-ATP-Akt pathway, diabetes. 66:1819–1832. https://doi.org/10.2337/db16-1172
Wang J, Yang W, Chen Z, Chen J, Meng Y, Feng B, Sun L, Dou L, Li J, Cui Q, Yang J (2018) Long noncoding RNA LncSHGL recruits hnRNPA1 to suppress hepatic gluconeogenesis and lipogenesis, diabetes, 67. 581–593. https://doi.org/10.2337/db17-0799
Yang W-L, Zhang C-Y, Ji W-Y, Zhao L-L, Yang F-Y, Zhang L, Cao X (2024) Berberine metabolites stimulate GLP-1 secretion by alleviating oxidative stress and mitochondrial dysfunction. Am J Chin Med 52:253–274. https://doi.org/10.1142/s0192415x24500113
Article CAS PubMed Google Scholar
Henrikson RC, Smith TJ (1994) Ultrastructure of cultured human orbital fibroblasts. Cell Tissue Res 278:629–631. https://doi.org/10.1007/bf00331384
Article CAS PubMed Google Scholar
Byeon HJ, Chae MK, Ko J, Lee EJ, Kikkawa DO, Jang SY, Yoon JS (2023) The role of adipsin, complement factor D, in the pathogenesis of graves’ orbitopathy. Invest Opthalmology Visual Sci 64:13. https://doi.org/10.1167/iovs.64.11.13
Wang N, Hou S-y, Qi X, Deng M, Cao J-m, Tong B-D, Xiong W (2021) LncRNA LPAL2/miR-1287-5p/EGFR Axis modulates TED-Derived orbital fibroblast activation through cell adhesion factors. J Clin Endocrinol Metabolism 106:e2866–e2886. https://doi.org/10.1210/clinem/dgab256
Patrick CC, Roztocil E, Husain F, Feldon SE, Woeller CF (2024) Tapinarof, an Aryl hydrocarbon receptor ligand, mitigates fibroblast activation in thyroid eye disease: implications for novel therapy. Investig Ophthalmol Vis Sci 65:40. https://doi.org/10.1167/iovs.65.13.40
Conover CA, Bale LK, Stan MN (2024) PAPP-A as a potential target in thyroid eye disease. J Clin Endocrinol Metab 109:3119–3125. https://doi.org/10.1210/clinem/dgae339
Article PubMed PubMed Central Google Scholar
Kim JY, Park S, Lee HJ, Lew H, Kim GJ (2020) Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with graves’ ophthalmopathy. Stem Cell Res Ther 11:469. https://doi.org/10.1186/s13287-020-01982-3
Article CAS PubMed PubMed Central Google Scholar
Zhuo J, Liu D, Yu Q, Hu M, Huang H, Chen Y, Li Y, Gao Y, Chen W, Meng X, Zou F, Zhang J, Cai S, Dong H (2024) Indole-3-acetic acid attenuates pulmonary fibrosis by modulating lung microbiota, inhibiting fibroblast activation, and alleviating alveolar epithelial cell senescence. Life Sci 359:123191. https://doi.org/10.1016/j.lfs.2024.123191
Article CAS PubMed Google Scholar
Sun R, Zhou HF, Fan XQ (2021) Ocular surface changes in graves’ ophthalmopathy. Int J Ophthalmol 14:616–621. https://doi.org/10.18240/ijo.2021.04.20
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