Oxidized metabolites of linoleic acid as biomarkers of pancreatic beta-cell function in the first-onset type 2 diabetic patients with obesity

Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N et al (2019) The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis. J Hepatol 71(4):793–801

Article  PubMed  Google Scholar 

Ruze R, Liu T, Zou X, Song J, Chen Y, Xu R et al (2023) Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments. Front Endocrinol (Lausanne) 14:1161521

Article  PubMed  Google Scholar 

Tong Y, Xu S, Huang L, Chen C (2022) Obesity and insulin resistance: pathophysiology and treatment. Drug Discov Today 27(3):822–830

Article  PubMed  Google Scholar 

Imai Y, Cousins RS, Liu S, Phelps BM, Promes JA (2020) Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes. Ann N Y Acad Sci 1461(1):53–72

Article  PubMed  Google Scholar 

Luc K, Schramm-Luc A, Guzik TJ, Mikolajczyk TP (2019) Oxidative stress and inflammatory markers in prediabetes and diabetes. J Physiol Pharmacol. 70(6): 809-824

Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97(10):2499–2574

Article  PubMed  PubMed Central  Google Scholar 

Andrés-Blasco I, Gallego-Martínez A, Machado X, Cruz-Espinosa J, Di Lauro S, Casaroli-Marano R et al (2023) Oxidative stress, inflammatory, angiogenic, and apoptotic molecules in proliferative diabetic retinopathy and diabetic macular edema patients. Int J Mol Sci. https://doi.org/10.3390/ijms24098227

Article  PubMed  PubMed Central  Google Scholar 

Tabatabaei-Malazy O, Khodaeian M, Bitarafan F, Larijani B (2017) Polymorphisms of antioxidant genes as a target for diabetes management. Int J Mol Cell Med 6(3):135–147

PubMed  PubMed Central  Google Scholar 

Balboa MA, Balsinde J (2006) Oxidative stress and arachidonic acid mobilization. Biochim Biophys Acta 1761(4):385–391

Article  PubMed  Google Scholar 

Persaud SJ, Muller D, Belin VD, Kitsou-Mylona I, Asare-Anane H, Papadimitriou A et al (2007) The role of arachidonic acid and its metabolites in insulin secretion from human islets of Langerhans. Diabetes 56(1):197–203

Article  PubMed  Google Scholar 

Wang R, Li B, Lam SM, Shui G (2020) Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet Genomics 47(2):69–83

Article  PubMed  Google Scholar 

Xu F, Tavintharan S, Sum CF, Woon K, Lim SC, Ong CN (2013) Metabolic signature shift in type 2 diabetes mellitus revealed by mass spectrometry-based metabolomics. J Clin Endocrinol Metab 98(6):E1060–E1065

Article  PubMed  Google Scholar 

Lin L, Dekkers IA, Huang L, Tao Q, Paiman EHM, Bizino MB et al (2021) Renal sinus fat volume in type 2 diabetes mellitus is associated with glycated hemoglobin and metabolic risk factors. J Diabetes Complications 35(9):107973

Article  PubMed  Google Scholar 

Quispe R, Martin SS, Jones SR (2016) Triglycerides to high-density lipoprotein-cholesterol ratio, glycemic control and cardiovascular risk in obese patients with type 2 diabetes. Curr Opin Endocrinol Diabetes Obes 23(2):150–156

Article  PubMed  Google Scholar 

Dhokte S, Czaja K (2024) Visceral adipose tissue: the hidden culprit for type 2 diabetes. Nutrients. https://doi.org/10.3390/nu16071015

Article  PubMed  PubMed Central  Google Scholar 

Ginsberg HN, Packard CJ, Chapman MJ, Borén J, Aguilar-Salinas CA, Averna M et al (2021) Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society. Eur Heart J 42(47):4791–806

Article  PubMed  PubMed Central  Google Scholar 

Sanoie M, Teymoori F, Abooshahab R, Akbarzadeh M, Asghari G, Yuzbashian E et al (2025) Plasma fatty acid profiles modulate PPARγ expression in adipose tissue: a lipidomic insight into obesity-related metabolic dysregulation. Endocrinology, Diabetes & Metabolism 8(5):e70080

Article  Google Scholar 

Ma S, Yada K, Lee H, Fukuda Y, Iida A, Suzuki K (2017) Taheebo polyphenols attenuate free fatty acid-induced inflammation in murine and human macrophage cell lines as inhibitor of cyclooxygenase-2. Front Nutr 4:63

Article  PubMed  PubMed Central  Google Scholar 

Wells MA, Vendrov KC, Edin ML, Ferslew BC, Zha W, Nguyen BK et al (2016) Characterization of the cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis. Prostaglandins Other Lipid Mediat 125:19–29

Article  PubMed  PubMed Central  Google Scholar 

Welch BM, McNell EE, Edin ML, Ferguson KK (2022) Inflammation and oxidative stress as mediators of the impacts of environmental exposures on human pregnancy: evidence from Oxylipins. Pharmacol Ther 239:108181

Article  PubMed  PubMed Central  Google Scholar 

Balestrieri B, Di Costanzo D, Dwyer DF (2021) Macrophage-mediated immune responses: from fatty acids to oxylipins. Molecules. https://doi.org/10.3390/molecules27010152

Article  PubMed  PubMed Central  Google Scholar 

Desoye G, Herrera E (2021) Adipose tissue development and lipid metabolism in the human fetus: the 2020 perspective focusing on maternal diabetes and obesity. Prog Lipid Res 81:101082

Article  PubMed  Google Scholar 

Dyall SC, Balas L, Bazan NG, Brenna JT, Chiang N, da Costa Souza F et al (2022) Polyunsaturated fatty acids and fatty acid-derived lipid mediators: recent advances in the Understanding of their biosynthesis, structures, and functions. Prog Lipid Res 86:101165

Article  PubMed  PubMed Central  Google Scholar 

Misheva M, Johnson J, McCullagh J (2022) Role of oxylipins in the inflammatory-related diseases NAFLD, obesity, and type 2 diabetes. Metabolites. https://doi.org/10.3390/metabo12121238

Article  PubMed  PubMed Central  Google Scholar 

Tans R, Bande R, van Rooij A, Molloy BJ, Stienstra R, Tack CJ et al (2020) Evaluation of cyclooxygenase Oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry. Prostaglandins Leukot Essent Fat Acids 160:102157

Article  Google Scholar 

Feugray G, Pereira T, Iacob M, Moreau-Grangé L, Prévost G, Brunel V et al (2022) Determination of lipoxygenase, CYP450, and non-enzymatic metabolites of arachidonic acid in essential hypertension and type 2 diabetes. Metabolites. https://doi.org/10.3390/metabo12090859

Article  PubMed  PubMed Central  Google Scholar 

Liu X, Gu Y, Kumar S, Amin S, Guo Q, Wang J et al (2023) Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Cell Metab 35(4):667–84e6

Article  PubMed  PubMed Central  Google Scholar 

Gorbatenko VO, Goriainov SV, Babenko VA, Plotnikov EY, Chistyakov DV, Sergeeva MG (2024) Tlr3-mediated astrocyte responses in high and normal glucose adaptation differently regulated by Metformin. Cell Biochem Biophys 82(3):2701–2715

Article  PubMed  Google Scholar 

Ávila-Román J, Talero E, de Los Reyes C, García-Mauriño S, Motilva V (2018) Microalgae-derived Oxylipins decrease inflammatory mediators by regulating the subcellular location of NFκB and PPAR-γ. Pharmacol Res 128:220–230

Article  PubMed  Google Scholar 

Harford KA, Reynolds CM, McGillicuddy FC, Roche HM (2011) Fats, inflammation and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue. Proc Nutr Soc 70(4):408–417

Article  PubMed  Google Scholar 

Jiménez-Franco A, Castañé H, Martínez-Navidad C, Placed-Gallego C, Hernández-Aguilera A, Fernández-Arroyo S et al (2024) Metabolic adaptations in severe obesity: insights from circulating oxylipins before and after weight loss. Clin Nutr 43(1):246–58

Article  PubMed  Google Scholar 

Milne GL, Yin H, Morrow JD (2008) Human biochemistry of the isoprostane pathway. J Biol Chem 283(23):15533–15537

Article  PubMed  PubMed Central  Google Scholar 

Roberts LJ 2nd, Morrow JD (2002) Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell Mol Life Sci 59(5):808–820

Westphal C, Konkel A, Schunck WH (2015) Cytochrome p450 enzymes in the bioactivation of polyunsaturated fatty acids and their role in cardiovascular disease. Adv Exp Med Biol 851:151–187

Article  PubMed 

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