I. Martín-Timón, C. Sevillano-Collantes, A. Segura-Galindo, F.J. Del Cañizo-Gómez, Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?. World. J. Diabetes 5, 444–4470 (2014).
Article PubMed PubMed Central Google Scholar
T. Yingchoncharoen, T. Limpijankit, S. Jongjirasiri, J. Laothamatas, S. Yamwong, P. Sritara, Arterial stiffness contributes to coronary artery disease risk prediction beyond the traditional risk score (RAMA-EGAT score). Heart. Asia 4, 77–82 (2012).
Article PubMed PubMed Central Google Scholar
P. Lacolley, V. Regnault, S. Laurent, Mechanisms of arterial stiffening: from mechanotransduction to epigenetics. Arterioscler. Thromb. Vasc. Biol. 40, 1055–1062 (2020).
Article CAS PubMed Google Scholar
R.M. Bruno, G. Penno, G. Daniele, L. Pucci, D. Lucchesi, F. Stea et al., Type 2 diabetes mellitus worsens arterial stiffness in hypertensive patients through endothelial dysfunction. Diabetologia 55, 1847–1855 (2012).
Article CAS PubMed Google Scholar
Z. Dogan, C. Ileri, E.A. Kay, M. Sunbul, E.Y. Gurel, B. Özben Sadıc et al., Evaluation of arterial stiffness parameters and the growth differentiation factor-15 level in patients with premature myocardial infarction. J. Pers. Med. 13, 1489 (2023).
Article PubMed PubMed Central Google Scholar
E. Sökmen, C. Uçar, S. Sivri, M. Çelik, K. Güçlü, Relationship of growth differentiation factor-15 with aortic stiffness in essential hypertension. Future. Sci. OA 5, Fso406 (2019).
Article PubMed PubMed Central Google Scholar
H.M. Al-Kuraishy, A.I. Al-Gareeb, A. Alexiou, M. Papadakis, E.H. Nadwa, S.M. Albogami et al., Metformin and growth differentiation factor 15 (GDF15) in type 2 diabetes mellitus: a hidden treasure. J. Diabetes 14, 806–814 (2022).
Article CAS PubMed PubMed Central Google Scholar
J.E. Deanfield, J.P. Halcox, T.J. Rabelink, Endothelial function and dysfunction: testing and clinical relevance. Circulation 115, 1285–1295 (2007).
X. Zhang, S. Low, K. Ang, L.Y. Yeoh, S. Tavintharan, C.F. Sum, S.C. Lim et al., Microvascular endothelial function is an independent predictor for albuminuria progression among Asians with type 2 diabetes-A prospective cohort study. Microcirculation 25, e12453 (2018).
R.G. Kalaitzidis, D.P. Karasavvidou, A. Tatsioni, K. Pappas, G. Katatsis, A. Liontos et al., Albuminuria as a marker of arterial stiffness in chronic kidney disease patients. World. J. Nephrol. 4, 406–414 (2015).
Article PubMed PubMed Central Google Scholar
S. Low, S. Pek, A. Moh, J.J. Liu, B. Pandian, K. Ang et al., The association between osteoprotegerin and arterial stiffness in a 10-year longitudinal study of patients with type 2 diabetes. Diab. Vasc. Dis. Res. 21, 14791641241304435 (2024).
Article CAS PubMed PubMed Central Google Scholar
S. Low, S.L.T. Pek, A.M.C. Moh, J. Khoo, K. Ang, W.E. Tang et al., Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients. Ann. Acad. Med. Singap. 52, 125–134 (2023).
D.A. Nation, C.E. Wierenga, L. Delano-Wood, A.J. Jak, D.C. Delis, D.P. Salmon et al., Elevated pulse pressure is associated with age-related decline in language ability. J. Int. Neuropsychol. Soc. 16, 933–938 (2010).
Article CAS PubMed PubMed Central Google Scholar
X. Zhang, S.C. Lim, S. Tavintharan, L.Y. Yeoh, C.F. Sum, K. Ang et al., Association of central arterial stiffness with the presence and severity of diabetic retinopathy in Asians with type 2 diabetes. Diab. Vasc. Dis. Res. 16, 498–505 (2019).
S. Low, A. Moh, K.S. Goh, J. Khoo, K. Ang, A.Y.L. Liu et al., Association between kidney disease index and decline in cognitive function with mediation by arterial stiffness in Asians with type 2 diabetes. J. Alzheimers Dis. Rep. 8, 1199–1210 (2024).
Article PubMed PubMed Central Google Scholar
S.L. Pek, S. Tavintharan, X. Wang, S.C. Lim, K. Woon, L.Y. Yeoh et al., Elevation of a novel angiogenic factor, leucine-rich-α2-glycoprotein (LRG1), is associated with arterial stiffness, endothelial dysfunction, and peripheral arterial disease in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 100, 1586–1593 (2015).
Article CAS PubMed Google Scholar
X. Zhang, J.J. Liu, C.F. Sum, Y.L. Yeoh, S. Tavintharan, X.W. Ng et al., Ethnic disparity in central arterial stiffness and its determinants among Asians with type 2 diabetes. Atherosclerosis 242, 22–28 (2015).
Article CAS PubMed Google Scholar
X. Zhang, S. Low, C.F. Sum, S. Tavintharan, L.Y. Yeoh, J. Liu et al., Arterial stiffness is an independent predictor for albuminuria progression among Asians with type 2 diabetes-A prospective cohort study. J. Diabetes Complications 31, 933–938 (2017).
M.C. Moh, S. Low, T.P. Ng, K. Ang, T. Subramaniam, C.F. Sum et al., Role of endothelium-independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes. Microcirculation 27, e12609 (2020).
Article CAS PubMed Google Scholar
S.C. Lim, N.G. Morgenthaler, T. Subramaniam, Y.S. Wu, S.K. Goh, C.F. Sum, The relationship between adrenomedullin, metabolic factors, and vascular function in individuals with type 2 diabetes. Diabetes. Care 30, 1513–1519 (2007).
Article CAS PubMed Google Scholar
A.S. Levey, L.A. Stevens, C.H. Schmid, Y.L. Zhang, A.F. Castro 3rd, H.I. Feldman et al., A new equation to estimate glomerular filtration rate. Ann. Intern. Med. 150, 604–612 (2009).
Article PubMed PubMed Central Google Scholar
L. Wik, N. Nordberg, J. Broberg, J. Björkesten, E. Assarsson, S. Henriksson et al., Proximity extension assay in combination with next-generation sequencing for high-throughput proteome-wide analysis. Mol. Cell Proteom. 20, 100168 (2021).
R.L. Gurung, H. Zheng, H.W.L. Koh, M. Yiamunaa, J.J. Liu, S. Liu et al., Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes. J. Clin. Endocrinol. Metab. 110, e239–e248 (2025).
Article CAS PubMed Google Scholar
R.L. Gurung, H. Zheng, B.T.K. Lee, S. Liu, J.J. Liu, C. Chan et al., Proteomics profiling and association with cardiorenal complications in type 2 diabetes subtypes in Asian population. Diabetes Res. Clin. Pract. 214, 111790 (2024).
Article CAS PubMed Google Scholar
R.M. Baron, D.A. Kenny, The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51, 1173–1182 (1986).
Article CAS PubMed Google Scholar
C. Andersson, D. Enserro, L. Sullivan, T.J. Wang, J.L. Januzzi Jr. et al., Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study. Atherosclerosis 248, 245–251 (2018).
A. Dieden, L. Malan, C.M.C. Mels, L. Lammertyn, A. Wentzel, P.M. Nilsson et al., Exploring biomarkers associated with deteriorating vascular health using a targeted proteomics chip: The SABPA Study. Medicine 100, e25936 (2021).
Article CAS PubMed PubMed Central Google Scholar
K. Mourouzis, G. Siasos, N. Bozini, E. Oikonomou, M. Zaromitidou, V. Tsigkou et al., Association of growth differentiation factor 15 with arterial stiffness and endothelial function in subpopulations of patients with coronary artery disease: A Proof-of-Concept Study. Recent. Adv. Inflamm. Allergy Drug. Discov. 16, 107–115 (2022).
Article CAS PubMed Google Scholar
I. Ikonomidis, K. Katogiannis, G. Pavlidis, J. Thymis, F. Kousathana, L. Pilouta et al., Association og GDF15, NTpoBNP and PLGF with subclinical cardiac dysfunction in type 2 diabetes: effects of novel antidiabetic treatment. European. Heart J. 44(Supplement 2), 1 (2023).
L. Wang, J. Luo, W. Liu, X. Huang, J. Xu, Y. Zhou et al., Elevated circulating growth differentiation factor 15 is related to decreased heart rate variability in chronic kidney disease patients. Renal. Fail. 43, 340–346 (2021).
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