Diverse modes of ceftazidime/avibactam resistance acquisition in carbapenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa from a Chinese intensive care unit

Papp-Wallace KM, Mack AR, Taracila MA, Bonomo RA. Resistance to novel β-lactam–β-lactamase inhibitor combinations. Infect Dis Clin North Am. 2020;34:773–819.

Article  PubMed  PubMed Central  Google Scholar 

Horcajada JP, Montero M, Oliver A, Sorlí L, Luque S, Gómez-Zorrilla S, Benito N, Grau S. Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections. Clin Microbiol Rev. 2019;32:e00031-e119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yahav D, Giske CG, Grāmatniece A, Abodakpi H, Tam VH, Leibovici L. New β-lactam–β-lactamase inhibitor combinations. Clin Microbiol Rev. 2020;34:e00115-e120.

Article  PubMed  PubMed Central  Google Scholar 

Ding L, Shen S, Chen J, Tian Z, Shi Q, Han R, Guo Y, Hu F. Klebsiella pneumoniae carbapenemase variants: the new threat to global public health. Clin Microbiol Rev. 2023;36:e00008-23.

Article  PubMed  PubMed Central  Google Scholar 

Zhang P, Wang J, Li Y, Shi W, Cai H, Yang Q, Li X, Yu Y, Qu T, Jiang Y. Emergence of blaKPC-33-harboring hypervirulent ST463 Pseudomonas aeruginosa causing fatal infections in China. J Infect. 2022;85:e86–8.

Article  CAS  PubMed  Google Scholar 

Faccone D, de Mendieta JM, Albornoz E, Chavez M, Genero F, Echegorry M, Ceriana P, Mora A, Seah C, Corso A, Melano RG, Pasteran F. Emergence of KPC-31, a KPC-3 variant associated with ceftazidime-avibactam resistance, in an extensively drug-resistant ST235 Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother. 2022;66:e00648-22.

Article  PubMed  PubMed Central  Google Scholar 

García P, Brito B, Alcalde-Rico M, Munita JM, Martínez JRW, Olivares-Pacheco J, Quiroz V, Wozniak A. Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance. Front Cell Infect Microbiol. 2022;12: 981792.

Article  PubMed  PubMed Central  Google Scholar 

Tu Y, Wang D, Zhu Y, Li J, Jiang Y, Wu W, Li X, Zhou H. Emergence of a KPC-90 variant that confers resistance to ceftazidime-avibactam in an ST463 carbapenem-resistant Pseudomonas aeruginosa strain. Microbiol Spectr. 2021;10:e01869-21.

Article  Google Scholar 

Yang Q, Li Y, Fang L, Lei T, Cai H, Hua X, Zheng M, Yu Y. A novel KPC-113 variant conferring carbapenem and ceftazidime-avibactam resistance in a multidrug-resistant Pseudomonas aeruginosa isolate. Clin Microbiol Infect. 2022;29:387.e7-387.14.

Article  PubMed  Google Scholar 

Chi X, Meng X, Xiong L, Chen T, Zhou Y, Ji J, Zheng B, Xiao Y. Small wards in the ICU: a favorable measure for controlling the transmission of carbapenem-resistant Klebsiella pneumoniae. Intensive Care Med. 2022;48:1573–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Chen J, Shen H, Chen Z, Yang Q, Zhu J, Li X, Yang Q, Zhao F, Ji J, Cai H, Li Y, Zhang L, Leptihn S, Hua X, Yu Y. Emergence of ceftazidime- and avibactam-resistant Klebsiella pneumoniae carbapenemase-producing Pseudomonas aeruginosa in China. mSystems. 2021;6:12.

Article  Google Scholar 

Hu Y, Liu C, Wang Q, Zeng Y, Sun Q, Shu L, Lu J, Cai J, Wang S, Zhang R, Wu Z. Emergence and expansion of a carbapenem-resistant Pseudomonas aeruginosa clone are associated with plasmid-borne blaKPC-2 and virulence-related genes. mSystems. 2021;6:e00154-21.

Article  PubMed  PubMed Central  Google Scholar 

Reyes J, Komarow L, Chen L, Ge L, Hanson BM, Cober E, Herc E, Alenazi T, Kaye KS, Garcia-Diaz J, Li L, Kanj SS, Liu Z, Oñate JM, Salata RA, Marimuthu K, Gao H, Zong Z, Valderrama-Beltrán SL, Yu Y, Tambyah P, Weston G, Salcedo S, Abbo LM, Xie Q, Ordoñez K, Wang M, Stryjewski ME, Munita JM, Paterson DL, Evans S, Hill C, Baum K, Bonomo RA, Kreiswirth BN, Villegas MV, Patel R, Arias CA, Chambers HF, Fowler VG, Doi Y, Van Duin D, Satlin MJ, Reyes J, Komarow L, Chen L, Ge L, Hanson B, Cober E, Herc E, Alenazi T, Kaye K, Garcia-Diaz J, Li L, Kanj S, Liu Z, Oñate J, Salata R, Marimuthu K, Gao H, Zong Z, Valderrama-Beltrán S, Yu Y, Tambyah P, Weston G, Salcedo S, Abbo L, Xie Q, Ordoñez K, Wang M, Stryjewski M, Munita J, Paterson D, Evans S, Hill C, Baum K, Bonomo R, Kreiswirth B, Virginia Villegas M, Patel R, Arias C, Chambers H, Fowler V, Doi Y, Van Duin D, Satlin M. Global epidemiology and clinical outcomes of carbapenem-resistant Pseudomonas aeruginosa and associated carbapenemases (POP): a prospective cohort study. Lancet Microbe. 2023;4:e159–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang P, Wu W, Wang N, Feng H, Wang J, Wang F, Zhang Y, Chen H, Yang Q, Jiang Y, Qu T. Pseudomonas aeruginosa high-risk sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases, China, 2020–2022. Emerg Infect Dis. 2023;29:2136–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Wang W, Liang M, Yu Q, Cai S, Lei T, Jiang Y, Du X, Zhou Z, Yu Y. A novel CMY variant confers transferable high-level resistance to ceftazidime-avibactam in multidrug-resistant Escherichia coli. Microbiol Spectr. 2023;11:e03349-22.

Article  PubMed  PubMed Central  Google Scholar 

Blanc DS, Magalhães B, Koenig I, Senn L, Grandbastien B. Comparison of whole genome (wg-) and core genome (cg-) MLST (BioNumericsTM) versus SNP variant calling for epidemiological investigation of Pseudomonas aeruginosa. Front Microbiol. 2020;11:1729.

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Fang L, Dong M, Cai H, Hua X, Jiang Y, Yu Y, Yang Q. bla KPC-2 overexpression and bla GES-5 carriage as major imipenem/relebactam resistance mechanisms in Pseudomonas aeruginosa high-risk clones ST463 and ST235, respectively, in China. Antimicrob Agents Chemother. 2023;67:e00675-23.

Article  PubMed  PubMed Central  Google Scholar 

Klucar L, Stano M, Hajduk M. phiSITE: database of gene regulation in bacteriophages. Nucleic Acids Res. 2010;38:D366–70.

Article  CAS  PubMed  Google Scholar 

Stano M, Klucar L. phiGENOME: an integrative navigation throughout bacteriophage genomes. Genomics. 2011;98:376–80.

Article  CAS  PubMed  Google Scholar 

Jin W, Wachino J, Yamaguchi Y, Kimura K, Kumar A, Yamada M, Morinaka A, Sakamaki Y, Yonezawa M, Kurosaki H, Arakawa Y. Structural insights into the TLA-3 extended-spectrum β-lactamase and its inhibition by avibactam and OP0595. Antimicrob Agents Chemother. 2017;61:e00501-e517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magiorakos A-P, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–81.

Article  CAS  PubMed  Google Scholar 

Li Y, Zhu Y, Zhou W, Chen Z, Moran RA, Ke H, Feng Y, van Schaik W, Shen H, Ji J, Ruan Z, Hua X, Yu Y. Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates. Clin Microbiol Infect. 2021;28:880.e1-880.e8.

Article  PubMed  Google Scholar 

Jiang M, Sun B, Huang Y, Liu C, Wang Y, Ren Y, Zhang Y, Wang Y, Mu D. Diversity of ceftazidime-avibactam resistance mechanism in KPC2-producing Klebsiella pneumoniae under antibiotic selection pressure. Infect Drug Resist. 2022;15:4627–36.

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Hu X, Zhao Y, Shi Y, Ding H, Xv J, Ren J, Wu R, Zhao Z. Genetic factors associated with enhanced blaKPC expression in Tn3/Tn4401 chimeras. Antimicrob Agents Chemother. 2020;64:e01836-e1919.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhanel GG, Lawrence CK, Adam H, Schweizer F, Zelenitsky S, Zhanel M, Lagacé-Wiens PRS, Walkty A, Denisuik A, Golden A, Gin AS, Hoban DJ, Lynch JP, Karlowsky JA. Imipenem-relebactam and meropenem–vaborbactam: two novel carbapenem-β-lactamase inhibitor combinations. Drugs. 2018;78:65–98.

Article  CAS  PubMed  Google Scholar 

Hu Y, Liu C, Shen Z, Zhou H, Cao J, Chen S, Lv H, Zhou M, Wang Q, Sun L, Sun Q, Hu F, Wang Y, Zhang R. Prevalence, risk factors and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae in patients from Zhejiang, China, 2008–2018. Emerg Microbes Infect. 2020;9:1771–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang X, Sun Q, Li J, Jiang Y, Li Y, Lin J, Chen K, Chan EW-C, Zhang R, Chen S. Molecular epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae in China. Emerg Microbes Infect. 2022;11:841–9.

Article  CAS  PubMed 

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