Association of sleep problems with suicidal behaviors and healthcare utilization in adults with chronic diseases: the role of mental illness

Diseases GBD, Injuries C. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the global burden of disease study 2021. Lancet. 2024;403(10440):2133–61.

Article  Google Scholar 

Bauer UE, Briss PA, Goodman RA, Bowman BA. Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA. Lancet. 2014;384(9937):45–52.

Article  PubMed  Google Scholar 

Steffler M, Li Y, Weir S, Shaikh S, Murtada F, Wright JG, Kantarevic J. Trends in prevalence of chronic disease and Multimorbidity in Ontario, Canada. CMAJ. 2021;193(8):E270–7.

Article  PubMed  PubMed Central  Google Scholar 

Ferro MA, Rhodes AE, Kimber M, Duncan L, Boyle MH, Georgiades K, Gonzalez A, MacMillan HL. Suicidal behaviour among adolescents and young adults with Self-Reported chronic illness. Can J Psychiatry. 2017;62(12):845–53.

Article  PubMed  PubMed Central  Google Scholar 

Kirtley OJ, Rodham K, Crane C. Understanding suicidal ideation and behaviour in individuals with chronic pain: a review of the role of novel transdiagnostic psychological factors. Lancet Psychiatry. 2020;7(3):282–90.

Article  PubMed  Google Scholar 

Dean-Boucher A, Robillard CL, Turner BJ. Chronic medical conditions and suicidal behaviors in a nationally representative sample of American adolescents. Soc Psychiatry Psychiatr Epidemiol. 2020;55(3):329–37.

Article  PubMed  Google Scholar 

Sporinova B, Manns B, Tonelli M, Hemmelgarn B, MacMaster F, Mitchell N, Au F, Ma Z, Weaver R, Quinn A. Association of mental health disorders with health care utilization and costs among adults with chronic disease. JAMA Netw Open. 2019;2(8):e199910.

Article  PubMed  PubMed Central  Google Scholar 

Kim H, Park SM, Jang SN, Kwon S. Depressive symptoms, chronic medical illness, and health care utilization: findings from the Korean longitudinal study of ageing (KLoSA). Int Psychogeriatr. 2011;23(8):1285–93.

Article  PubMed  Google Scholar 

Han KM, Ko YH, Yoon HK, Han C, Ham BJ, Kim YK. Relationship of depression, chronic disease, self-rated health, and gender with health care utilization among community-living elderly. J Affect Disord. 2018;241:402–10.

Article  PubMed  Google Scholar 

Nie Q, Shen Y, Luo M, Sheng Z, Zhou R, Li G, Huang W, Chen S. Analysis of sleep for the American population: result from NHANES database. J Affect Disord. 2024;347:134–43.

Article  PubMed  Google Scholar 

Chu Y, Aune D, Yu C, Wu Y, Ferrari G, Rezende LFM, Wang Y. Temporal trends in sleep pattern among Chinese adults between 2010 and 2018: findings from five consecutive nationally representative surveys. Public Health. 2023;225:360–8.

Article  PubMed  CAS  Google Scholar 

Li J, Cao D, Huang Y, Chen Z, Wang R, Dong Q, Wei Q, Liu L. Sleep duration and health outcomes: an umbrella review. Sleep Breath. 2022;26(3):1479–501.

Article  PubMed  Google Scholar 

Stubbs B, Wu YT, Prina AM, Leng Y, Cosco TD. A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness. J Psychiatr Res. 2016;82:149–54.

Article  PubMed  Google Scholar 

Liu RT, Steele SJ, Hamilton JL, Do QBP, Furbish K, Burke TA, Martinez AP, Gerlus N. Sleep and suicide: A systematic review and meta-analysis of longitudinal studies. Clin Psychol Rev. 2020;81:101895.

Article  PubMed  PubMed Central  Google Scholar 

Statistics Canada. Canadian Community Health Survey - Annual Component (CCHS). https://www23.statcan.gc.ca/imdb/p2SV.pl?Function=getSurvey&Id=238854. Accessed 10 Jan 2025.

Dai H, Mei Z, An A, Wu J. Association between sleep problems and health-related quality of life in Canadian adults with chronic diseases. Sleep Med. 2019;61:26–30.

Article  PubMed  Google Scholar 

Faubel R, Lopez-Garcia E, Guallar-Castillon P, Balboa-Castillo T, Gutierrez-Fisac JL, Banegas JR, Rodriguez-Artalejo F. Sleep duration and health-related quality of life among older adults: a population-based cohort in Spain. Sleep. 2009;32(8):1059–68.

PubMed  PubMed Central  Google Scholar 

Garland SN, Rowe H, Repa LM, Fowler K, Zhou ES, Grandner MA. A decade’s difference: 10-year change in insomnia symptom prevalence in Canada depends on sociodemographics and health status. Sleep Health. 2018;4(2):160–5.

Article  PubMed  PubMed Central  Google Scholar 

Power JD, Perruccio AV, Badley EM. Pain as a mediator of sleep problems in arthritis and other chronic conditions. Arthritis Rheum. 2005;53(6):911–9.

Article  PubMed  Google Scholar 

Chaput JP, Yau J, Rao DP, Morin CM. Prevalence of insomnia for Canadians aged 6 to 79. Health Rep. 2018;29(12):16–20.

PubMed  Google Scholar 

Khan S. Concurrent mental and substance use disorders in Canada. Health Rep. 2017;28(8):3–8.

PubMed  Google Scholar 

Nguyen HV, Mital S. Effects of e-cigarette use on mental health among youths: quasi-experimental evidence from Canada. Addiction. 2022;117(10):2673–82.

Article  PubMed  Google Scholar 

Asbridge M, Ralph K, Stewart S. Private space second-hand smoke exposure and the mental health of non-smokers: a cross-sectional analysis of Canadian adults. Addict Behav. 2013;38(3):1679–86.

Article  PubMed  Google Scholar 

Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.

Article  PubMed  CAS  Google Scholar 

Kelly SM, Updegraff JA. Substituting activities mediates the effect of cognitive flexibility on physical activity: a daily diary study. J Behav Med. 2017;40(4):669–74.

Article  PubMed  Google Scholar 

Liu RT, Steele SJ, Hamilton JL, Do QBP, Furbish K, Burke TA, Martinez AP, Gerlus N. Sleep and suicide: A systematic review and meta-analysis of longitudinal studies. Clin Psychol Rev. 2020;81:101895. https://doi.org/10.1016/j.cpr.2020.101895).

Article  PubMed  PubMed Central  Google Scholar 

Garbarino S, Lanteri P, Bragazzi NL, Magnavita N, Scoditti E. Role of sleep deprivation in immune-related disease risk and outcomes. Commun Biol. 2021;4(1):1304. https://doi.org/10.1038/s42003-021-02825-4;2.

Article  PubMed  PubMed Central  Google Scholar 

Herzog S, Bartlett EA, Zanderigo F, Galfalvy HC, Burke A, Mintz A, Schmidt M, Hauser E, Huang YY, Melhem N, Sublette ME, Miller JM, Mann JJ. Neuroinflammation, Stress-Related suicidal ideation, and negative mood in depression. JAMA Psychiatry. 2025;82(1):85–93. https://doi.org/10.1001/jamapsychiatry.2024.3543.

Article  PubMed  Google Scholar 

Hoprekstad GE, Skrede S, Bartz-Johannessen C, Joa I, Reitan SK, Steen VM, Torsvik A, Johnsen E, Kroken RA, Rettenbacher M. Association between cytokines and suicidality in patients with psychosis: A multicentre longitudinal analysis. Brain Behav Immun Health. 2024;37:100756. https://doi.org/10.1016/j.bbih.2024.100756.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sălcudean A, Bodo CR, Popovici RA, Cozma MM, Păcurar M, Crăciun RE, Crisan AI, Enatescu VR, Marinescu I, Cimpian DM, Nan AG, Sasu AB, Anculia RC, Strete EG. Neuroinflammation-A crucial factor in the pathophysiology of Depression-A comprehensive review. Biomolecules. 2025;15(4):502. https://doi.org/10.3390/biom15040502.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rogante E, Cifrodelli M, Sarubbi S, Costanza A, Erbuto D, Berardelli I, Pompili M. The role of emotion dysregulation in Understanding suicide risk: A systematic review of the literature. Healthc (Basel). 2024;12(2):169. https://doi.org/10.3390/healthcare12020169.

Article  Google Scholar 

Baldini V, Gnazzo M, Maragno M, Biagetti R, Stefanini C, Canulli F, Varallo G, Donati C, Neri G, Fiorillo A, Plazzi G. Suicidal risk among adolescent psychiatric inpatients: the role of insomnia, depression, and social-personal factors. Eur Psychiatry. 2025;68(1):e42. https://doi.org/10.1192/j.eurpsy.2025.29.

Article  PubMed  PubMed Central  Google Scholar 

Saghir Z, Syeda JN, Muhammad AS, Balla Abdalla TH, Kim S, Lee D. The amygdala, sleep debt, sleep deprivation, and the emotion of anger: A possible connection?? CureusBiol Psychiatry. 20182011;10(7):e2912.

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