Available online 20 June 2025

Unresolved inflammation can progress into severe diseases that need safer and more effective therapeutic strategies. The adverse effects of conventional anti-inflammatory agents have evoked interest in natural products as alternatives. Panax ginseng is a traditional medical herb famous for its diverse pharmacological properties. This review comprehensively discusses the anti-inflammatory effects of P. ginseng and its constituents against inflammatory bowel disease, hepatitis, sepsis, gastritis, atopic dermatitis, acute lung disease, and rheumatoid arthritis. We summarize the therapeutic effects and underlying molecular mechanisms of P. ginseng reported in studies published as of February 2025. Our review highlights the potential of P. ginseng as an anti-inflammatory agent or functional food that affects the interconnected disease network.

Panax ginseng

inflammatory bowel disease

hepatitis

sepsis

gastritis

atopic dermatitis

acute lung disease

and rheumatoid arthritis

© 2025 The Korean Society of Ginseng. Publishing services by Elsevier B.V.