Izadi M, Kheirjou R, Mohammadpour R, Aliyoldashi MH, Moghadam SJ, Khorvash F, Jafari NJ, Shirvani S, Khalili N. Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes Metab Syndr. 2019;13:822–5.

Article  PubMed  Google Scholar 

Subrata SA, Phuphaibul R. Diabetic foot ulcer care: a concept analysis of the term integrated into nursing practice. Scand J Caring Sci. 2019;33:298–310.

Article  PubMed  Google Scholar 

Alsabek MB, Abdul AA. Diabetic foot ulcer, the effect of resource-poor environments on healing time and direct cost: a cohort study during Syrian crisis. Int Wound J. 2022;19:531–7.

Article  PubMed  Google Scholar 

Sharma R, Sharma SK, Mudgal SK, Jelly P, Thakur K. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials. Sci Rep. 2021;11:2189.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang L, Zhao N, Yang M, Huang J, Fu X, Lei C, Cai P. Diabetic foot wound ulcers management by vacuum sealing drainage: a meta-analysis. Int Wound J. 2024;21: e14390.

Article  PubMed  Google Scholar 

Xu J, Hua Y, Lei J, Peng X, Cheng L, Jiang Q, Yang J. Effects of skin flap grafting combined with vacuum sealing drainage on ulcer area, pain level, and serum inflammation in diabetic foot patients. Am J Transl Res. 2023;15:6939–48.

CAS  PubMed  PubMed Central  Google Scholar 

Huang Q, Wang JT, Gu HC, Cao G, Cao JC. Comparison of vacuum sealing drainage and traditional therapy for treatment of diabetic foot ulcers: a meta-analysis. J Foot Ankle Surg. 2019;58:954–8.

Article  PubMed  Google Scholar 

Bai XG, Wang J, Li X, Li W, Xu J. A protocol of systematic review and meta-analysis of continuous vacuum sealing drainage for diabetic foot ulcer. Medicine (Baltimore). 2020;99: e20541.

Article  PubMed  Google Scholar 

Machado-Alba JE, Machado-Duque ME. Use of intravenous alprostadil in patients with severe critical ischemia of the lower limbs. Vascular. 2019;27:318–23.

Article  CAS  PubMed  Google Scholar 

Wu JD, Tao S, Jin X, Jiang LL, Shen Y, Luo Y, Zhang P, Lee KO, Ye L, Ma JH. PGE1 improves diabetic peripheral neuropathy in patients with type 2 diabetes. Prostaglandins Other Lipid Mediat. 2016;126:24–8.

Article  CAS  PubMed  Google Scholar 

Agathos E, Tentolouris A, Eleftheriadou I, Katsaouni P, Nemtzas I, Petrou A, Papanikolaou C, Tentolouris N. Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy. J Int Med Res. 2018;46:1779–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Liu K, Jiang T, Ren S, Kang Y, Li W, Yao H, Yang X, Dai H, Chen Z. Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing. Mater Sci Eng C Mater Biol Appl. 2021;131: 112519.

Article  CAS  PubMed  Google Scholar 

Cao X, Chen P. The effects of alprostadil combined with α-lipoic acid in the treatment of senile diabetic nephropathy. Am J Transl Res. 2021;13:10823–9.

CAS  PubMed  PubMed Central  Google Scholar 

Kapoor S. Pain Management in patients with diabetic nephropathy: the emerging role of α-lipoic acid. Foot Ankle Spec. 2012;5:228–9.

Article  PubMed  Google Scholar 

Guan H, Ye M, Fang C, Zhang L, Han P, Qiu S, Fang X, Li L. The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: a protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99: e23507.

Article  CAS  PubMed  Google Scholar 

Volchegorskiĭ IA, Alekseev MN, Volchegorskaia MI, Rassokhina LM. Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome. Klin Med (Mosk). 2008;86:52–9.

PubMed  Google Scholar 

Lavery LA, Davis KE, Berriman SJ, Braun L, Nichols A, Kim PJ, Margolis D, Peters EJ, Attinger C. WHS guidelines update: diabetic foot ulcer treatment guidelines. Wound Repair Regen. 2016;24:112–26.

Article  PubMed  Google Scholar 

Eraydin Ş, Avşar G. The effect of foot exercises on wound healing in type 2 diabetic patients with a foot ulcer: a randomized control study. J Wound Ostomy Continence Nurs. 2018;45:123–30.

Article  PubMed  Google Scholar 

Sultana R, Ahmed I, Saima S, Salam MT, Sultana S. Diabetic foot ulcer-a systematic review on relevant microbial etiology and antibiotic resistance in Asian countries. Diabetes Metab Syndr. 2023;17: 102783.

Article  CAS  PubMed  Google Scholar 

Jodheea-Jutton A, Hindocha S, Bhaw-Luximon A. Health economics of diabetic foot ulcer and recent trends to accelerate treatment. Foot (Edinb). 2022;52: 101909.

Article  PubMed  Google Scholar 

Ramachandran V, Mohanasundaram T, Karunakaran D, Gunasekaran M, Tiwari R. Physiological and pathophysiological aspects of diabetic foot ulcer and its treatment strategies. Curr Diabetes Rev. 2023;19: e1057439545.

Article  Google Scholar 

Mariadoss A, Sivakumar AS, Lee CH, Kim SJ. Diabetes mellitus and diabetic foot ulcer: etiology, biochemical and molecular based treatment strategies via gene and nanotherapy. Biomed Pharmacother. 2022;151: 113134.

Article  CAS  PubMed  Google Scholar 

Yin XL, Hu L, Li T, Zou Y, Li HL. A meta-analysis on the efficacy of vacuum sealing drainage combined with autologous platelet-rich plasma in the treatment of Grade 2 and Grade 3 diabetic foot ulcers. Int Wound J. 2023;20:1033–41.

Article  PubMed  Google Scholar 

Xu J, Wang QY, Li W. Autologous platelet-rich gel and continuous vacuum sealing drainage for the treatment of patients with diabetic foot ulcer: study protocol. Medicine (Baltimore). 2019;98: e17928.

Article  PubMed  Google Scholar 

Zhang L, Zhang JC, Pang ZX, Wang YB. Clinical study of vacuum suction therapy combined with Alprostadil and Apalstat in the treatment of diabetic foot ulcers. J Hebei Med Univ. 2020;41:532–5.

Google Scholar 

Park JY, Jin SJ, Suh HP, Lee SA, Cho C, Yu J, Hwang JH, Hong JP, Kim YK. The role of age in determining the effects of lipo-PGE1 infusion on immediate arterial maximal flow velocity in patients with diabetes undergoing free flap surgery for lower extremity reconstruction: a prospective observational study. J Plast Reconstr Aesthet Surg. 2020;73:885–92.>

Article  PubMed  Google Scholar 

Nasole E, Nicoletti C, Yang ZJ, Girelli A, Rubini A, Giuffreda F, Di Tano A, Camporesi E, Bosco G. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. J Enzyme Inhib Med Chem. 2014;29:297–302.

Article  CAS  PubMed  Google Scholar 

Jiang DQ, Li MX, Wang Y, Wang Y. Effects of prostaglandin E1 plus methylcobalamin alone and in combination with lipoic acid on nerve conduction velocity in patients with diabetic peripheral neuropathy: a meta-analysis. Neurosci Lett. 2015;594:23–9.

Article  CAS  PubMed  Google Scholar 

Zhang L, Zhang HY, Huang FC, Huang Q, Liu C, Li JR. Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients with erectile dysfunction. Eur Rev Med Pharmacol Sci. 2016;20:3930–3.

CAS  PubMed  Google Scholar 

Zhu G, Xu J, Dai H, Min D, Guo G. Effect of peripheral nerve block versus general anesthesia on the hemodynamics and prognosis of diabetic patients undergoing diabetic foot Surgery. Diabetol Metab Syndr. 2023;15:213.

Article  PubMed  PubMed Central  Google Scholar 

Aslan S, Demirdal T, Erbak H, Aslan C. The role of soluble urokinase plasminogen activator receptor (suPAR) in the diagnostics of diabetic foot infection. Infect Dis (Lond). 2020;52:107–13.

Article  CAS  PubMed  Google Scholar 

Kulwas A, Lisewska B, Jundziłł W, Ruszkowska B, Drewniak W, Ruprecht Z, Gadomska G, Rość D. Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) in diabetic foot syndrome. Adv Med Sci. 2017;62:87–91.

Article  PubMed  Google Scholar 

Zhang J, Gu C, Lawrence DA, Cheung AK, Huang Y. A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes. Exp Physiol. 2014;99:802–15.>