Differential diagnosis of heritable and acquired osteomalacia in children: biochemical and biomaterial signatures

Arnold A, Dennison E, Kovacs CS, Mannstadt M, Rizzoli R, Brandi ML, et al (2021) Hormonal regulation of biomineralization, vol 17, Nat Rev Endocrinol, pp 261–27.

Uday S, Högler W (2018) Rickets and Osteomalacia. In: Huhtaniem I, Martini L, (eds) Reference module in biomedical sciences, 2nd edn. Elsevier Inc

El-Gazzar A, Högler W (2021) Mechanisms of bone fragility: From osteogenesis imperfecta to secondary osteoporosis. Int J Mol Sci 22(2):1–18

Article  Google Scholar 

Ward LM, Weber DR, Munns CF, Högler W, Zemel BS (2020) A contemporary view of the definition and diagnosis of osteoporosis in children and adolescents. J Clin Endocrinol Metab 105(5):2088–2097

Article  Google Scholar 

Ciancia S, van Rijn RR, Högler W, Appelman-Dijkstra NM, Boot AM, Sas TCJ et al (2022) Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Eur J Pediatr 181(7):2549–2561

Article  PubMed  PubMed Central  Google Scholar 

Mäkitie O (2013) Causes, mechanisms and management of paediatric osteoporosis. Nat Rev Rheumatol 9(8):465–475

Article  PubMed  Google Scholar 

Högler W, Ward L (2015) Osteoporosis in children with chronic disease. In: Calcium and bone disorders in children and adolescents, 2nd edn, pp 76–95

Uday S, Högler W (2023) Growth plate histology, bone histomorphometry, and radiologic features of nutritional rickets and osteomalacia. In: Hewison M, Bouillon R, Giovannucci E, Goltzman D, Meyer M, Welsh J (eds) Feldman and Pike’s Vitamin D: volume two: disease and therapeutics, 5th edn. Academic Press, pp 223–40

Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319–326

Article  CAS  PubMed  Google Scholar 

Rauch F (2011) Pediatric bone histomorphometry. In: Glorieux FH, Pettifor, John M, Jüppner H (eds) Pediatric bone: biology and diseases, 2nd. Academic Press, pp 383–401

Ralston SH (2005) Bone densitometry and bone biopsy. Best Pract Res Clin Rheumatol 19(3):487–501

Article  PubMed  Google Scholar 

Glorieux FH, Travers R, Taylor A, Bowen JR, Rauch F, Norman M et al (2000) Normative data for iliac bone histomorphometry in growing children. Bone 26(2):103–109

Article  CAS  PubMed  Google Scholar 

Lindsay R, Cosman F, Zhou H, Bostrom MP, Shen VW, Cruz JAD et al (2006) A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide. J Bone Miner Res 21(3):366–373

Article  CAS  PubMed  Google Scholar 

Parfitt AM, Drenzner M, Glorieux FH, Kanis JA, Malluche H, Meunier P et al (1987) Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 2(6):595–610

Article  CAS  PubMed  Google Scholar 

Dempster DW, Compston JE, Drezner MK, Glorieux FH, Kanis JA, Malluche H et al (2013) Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res 28(1):1–16

Article  Google Scholar 

Parfitt AM (2003) Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry. Curr Opin Nephrol Hypertens 12(4):387–403

Article  PubMed  Google Scholar 

Bhan A, Qiu S, Rao SD (2018) Bone histomorphometry in the evaluation of osteomalacia. Bone Rep 8:125–134

Article  PubMed  PubMed Central  Google Scholar 

Tsourdi E, Jähn K, Rauner M, Busse B, Bonewald LF (2018) Physiological and pathological osteocytic osteolysis. J Musculoskelet Neuronal Interact 18(3):292–303

CAS  PubMed  PubMed Central  Google Scholar 

Mosekilde L, Melsen F (1978) A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism. Acta Med Scand 204(1–2):97–102

Article  CAS  PubMed  Google Scholar 

Schnitzler CM, Pettifor JM (2019) Calcium deficiency rickets in african adolescents: cortical bone histomorphometry. JBMR Plus 3(6):1–10

Article  Google Scholar 

Rolvien T, Krause M, Jeschke A, Yorgan T, Püschel K, Schinke T et al (2017) Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone. Bone 103:78–87

Article  CAS  PubMed  Google Scholar 

Qing H, Ardeshirpour L, Divieti Pajevic P, Dusevich V, Jähn K, Kato S et al (2012) Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation. J Bone Miner Res 27(5):1018–1029

Article  CAS  PubMed  Google Scholar 

Robinson ME, AlQuorain H, Murshed M, Rauch F (2020) Mineralized tissues in hypophosphatemic rickets, vol 35, Pediatric Nephrology, pp 1843–54

Roschger P, Paschalis EP, Fratzl P, Klaushofer K (2008) Bone mineralization density distribution in health and disease. Bone 42(3):456–466

Article  CAS  PubMed  Google Scholar 

Roschger P, Gupta HS, Berzlanovich A, Ittner G, Dempster DW, Fratzl P et al (2003) Constant mineralization density distribution in cancellous human bone. Bone 32(3):316–323

Article  CAS  PubMed  Google Scholar 

Fratzl-Zelman N, Roschger P, Misof BM, Pfeffer S, Glorieux FH, Klaushofer K et al (2009) Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults. Bone 44(6):1043–1048

Article  CAS  PubMed  Google Scholar 

Hartmann MA, Blouin S, Misof BM, Fratzl-Zelman N, Roschger P, Berzlanovich A et al (2021) Quantitative backscattered electron imaging of bone using a thermionic or a field emission electron source. Calcif Tissue Int 109(2):190–202

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uday S, Högler W (2018) Prevention of rickets and osteomalacia in the UK: political action overdue. Arch Dis Child 103(9):901–906

Article  PubMed  Google Scholar 

Uday S, Högler W (2017) Nutritional rickets and osteomalacia in the twenty-first century: revised concepts, public health, and prevention strategies. Curr Osteoporos Rep 15(4):293–302

Article  PubMed  PubMed Central  Google Scholar 

Nordblad M, Graham F, Mughal MZ, Padidela R (2016) Rapid assessment of dietary calcium intake. Arch Dis Child 101(7):634–636

Article  PubMed  Google Scholar 

Uday S, Högler W (2022) The burden of vitamin D deficiency in household members of children presenting with symptomatic vitamin D deficiency. Front Endocrinol (Lausanne) 13:958422

Article  PubMed  Google Scholar 

Garabédian M, Vainsel M, Mallet E, Guillozo H, Toppet M, Grimberg R et al (1983) Circulating vitamin D metabolite concentrations in children with nutritional rickets. J Pediatr 103(3):381–386

Article  PubMed  Google Scholar 

Goel K, Sweet E, Logan R, Warren J, Arneil G, Shanks R (1976) Florid and subclinical rickets among immigrant children in Glasgow. Lancet 307(7970):1141–1145

Article  Google Scholar 

Pettifor JM, Isdale JM, Sahakian J, Hansen JD (1980) Diagnosis of subclinical rickets. Arch Dis Child 55(2):155–157

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pettifor JM (2003) Nutritional rickets. In: Pediatric bone: biology & diseases, pp 541–565

Thandrayen K, Pettifor JM (2018) The roles of vitamin D and dietary calcium in nutritional rickets. Bone Reports 8:81–89

Article  PubMed  PubMed Central  Google Scholar 

Shore RM, Chesney RW (2013) Rickets: Part II. Pediatr Radiol 43:152–172

Article  PubMed  Google Scholar 

Griffiths HJL (1979) Hyperparathyroidism. Orthopedics 2(6):629–634

Article  CAS  PubMed  Google Scholar 

Julies P, Lynn RM, Pall K, Leoni M, Calder A, Mughal Z et al (2020) Nutritional rickets under 16 years : UK surveillance results. Arch Dis Child 105(6):587–592

Article  PubMed  Google Scholar 

Schnitzler CM, Pettifor JM, Patel D, Mesquita JM, Moodley GP, Zachen D (1994) Metabolic bone disease in black teenagers with genu valgum or varum without radiologic rickets: a bone histomorphometric study. J Bone Miner Res 9(4):479–486

Comments (0)

No login
gif