Safety of nonselective nonsteroidal anti-inflammatory drugs in cardiac surgery: a historical cohort study

Mangano D, Siliciano D, Hollenberg M, Leung J, Browner W. Postoperative myocardial ischemia. Therapeutic trials using intensive analgesia following surgery. The Study of Perioperative Ischemia (SPI) Research Group. Anesthesiology 1992; 76: 342–53.

Article  CAS  PubMed  Google Scholar 

White PF, Kehlet H, Neal JM, et al. The role of the anesthesiologist in fast-track surgery: From multimodal analgesia to perioperative medical care. Anesth Analg 2007;104:1380–96. https://doi.org/10.1213/01.ane.0000263034.96885.e1

Article  PubMed  Google Scholar 

Zubrzycki M, Liebold A, Skrabal C, et al. Assessment and pathophysiology of pain in cardiac surgery. J Pain Res 2018;11:1599–611. https://doi.org/10.2147/jpr.s162067

Article  PubMed  PubMed Central  Google Scholar 

Wick EC, Grant MC, Wu CL. Postoperative multimodal analgesia pain management with nonopioid analgesics and techniques: a review. JAMA Surg 2017;152:691–7. https://doi.org/10.1001/jamasurg.2017.0898

Article  PubMed  Google Scholar 

Engelman DT, Ben Ali W, Williams JB, et al. Guidelines for perioperative care in cardiac surgery: Enhanced Recovery after Surgery Society recommendations. JAMA Surg 2019;154:755–66. https://doi.org/10.1001/jamasurg.2019.1153

Article  PubMed  Google Scholar 

Chang RW, Tompkins DM, Cohn SM. Are NSAIDs safe? Assessing the risk-benefit profile of nonsteroidal anti-inflammatory drug use in postoperative pain management. Am Surg 2021;87:872–9. https://doi.org/10.1177/0003134820952834

Article  PubMed  Google Scholar 

Huerta C, Castellsague J, Varas-Lorenzo C, García Rodríguez LA. Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population. Am J Kidney Dis 2005;45:531–9. https://doi.org/10.1053/j.ajkd.2004.12.005

Article  CAS  PubMed  Google Scholar 

Maxwell SR, Payne RA, Murray GD, Webb DJ. Selectivity of NSAIDs for COX-2 and cardiovascular outcome. Br J Clin Pharmacol 2006;62:243–5. https://doi.org/10.1111/j.1365-2125.2006.02620.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angiolillo DJ, Weisman SM. Clinical pharmacology and cardiovascular safety of naproxen. Am J Cardiovasc Drugs 2017;17:97–107. https://doi.org/10.1007/s40256-016-0200-5

Article  CAS  PubMed  Google Scholar 

U.S. Food and Drug Administration. Memorandum: Analysis and recommendations for Agency action regarding non-steroidal anti-inflammatory drugs and cardiovascular risk; 2005. Available from URL: https://www.fda.gov/media/74279/download (accessed December 2024).

Ott E, Nussmeier NA, Duke PC, et al. Efficacy and safety of the cyclooxygenase 2 inhibitors parecoxib and valdecoxib in patients undergoing coronary artery bypass surgery. J Thorac Cardiovasc Surg 2003;125:1481–92. https://doi.org/10.1016/s0022-5223(03)00125-9

Article  CAS  PubMed  Google Scholar 

Nussmeier NA, Whelton AA, Brown MT, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. N Engl J Med 2005;352:1081–91. https://doi.org/10.1056/nejmoa050330

Article  CAS  PubMed  Google Scholar 

FDA U.S. Food and Drug Administration. FDA strengthens warning that non-aspirin nonsteroidal anti- inflammatory drugs (NSAIDs) can cause heart attacks or strokes; 2015. Available from URL: https://www.fda.gov/downloads/Drugs/DrugSafety/UCM453941.pdf (accessed December 2024).

Hynninen MS, Cheng DC, Hossain I, et al. Non-steroidal anti-inflammatory drugs in treatment of postoperative pain after cardiac surgery. Can J Anesth 2000;47:1182–7. https://doi.org/10.1007/BF03019866

Article  CAS  PubMed  Google Scholar 

Kulik A, Bykov K, Choudhry NK, Bateman BT. Non-steroidal anti-inflammatory drug administration after coronary artery bypass surgery: utilization persists despite the boxed warning. Pharmacoepidemiol Drug Saf 2015;24:647–53. https://doi.org/10.1002/pds.3788

Article  CAS  PubMed  Google Scholar 

Qazi SM, Sindby EJ, Nørgaard MA. Ibuprofen—a safe analgesic during cardiac surgery recovery? A randomized controlled trial. J Cardiovasc Thorac Res 2015;7: 141–8. https://doi.org/10.15171/jcvtr.2015.31

Article  PubMed  PubMed Central  Google Scholar 

Oliveri L, Jerzewski K, Kulik A. Black box warning: is ketorolac safe for use after cardiac surgery? J Cardiothorac Vasc Anesth 2014;28:274–9.https://doi.org/10.1053/j.jvca.2013.07.014

Article  CAS  PubMed  Google Scholar 

de Souza Brito F, Mehta RH, Lopes RD, et al. Nonsteroidal anti-inflammatory drugs and clinical outcomes in patients undergoing coronary artery bypass surgery. Am J Med 2017;130:462–8. https://doi.org/10.1016/j.amjmed.2016.10.023

Article  CAS  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008;61:344–9. https://doi.org/10.1016/j.jclinepi.2007.11.008

Article  Google Scholar 

Mehran R, Rao SV, Bhatt DL,et al. Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium. Circulation 2011;123:2736–47. https://doi.org/10.1161/circulationaha.110.009449

Article  PubMed  Google Scholar 

Lopes JA, Jorge S. The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin Kidney J 2013;6:8–14. https://doi.org/10.1093/ckj/sfs160

Article  PubMed  Google Scholar 

Gilbert EH, Lowenstein SR, Koziol-McLain J, Barta DC, Steiner J. Chart reviews in emergency medicine research: where are the methods? Ann Emerg Med 1996;27:305–8. https://doi.org/10.1016/s0196-0644(96)70264-0

Article  CAS  PubMed  Google Scholar 

Worster A, Bledsoe RD, Cleve P, Fernandes CM, Upadhye S, Eva K. Reassessing the methods of medical record review studies in emergency medicine research. Ann Emerg Med 2005;45:448–51. https://doi.org/10.1016/j.annemergmed.2004.11.021

Article  PubMed  Google Scholar 

Kowarik A, Templ M. Imputation with the R package VIM. J Stat Softw 2016;74: 1–16. https://doi.org/10.18637/jss.v074.i07

Article  Google Scholar 

Kursa MB, Rudnicki WR. Feature selection with the boruta package. J Stat Softw 2010;36:1–13. https://doi.org/10.18637/jss.v036.i11

Article  Google Scholar 

Lewis MJ, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes MR. nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data. Bioinforma Adv 2023;3: vbad048. https://doi.org/10.1093/bioadv/vbad048

Article  Google Scholar 

Huang C, Li SX, Caraballo C, et al. Performance metrics for the comparative analysis of clinical risk prediction models employing machine learning. Circ Cardiovasc Qual Outcomes 2021;14:E007526. https://doi.org/10.1161/circoutcomes.120.007526

Article  PubMed  Google Scholar 

Rozemberczki B, Watson L, Bayer P, et al. The Shapley value in machine learning. Int Jt Conf Artif Intell 2022;https://doi.org/10.48550/arXiv.2202.05594

Mehaffey JH, Hayanga JW, Kawsara M, et al. Contemporary coronary artery bypass grafting vs multivessel percutaneous coronary intervention. Ann Thorac Surg2023;116:1213–20. https://doi.org/10.1016/j.athoracsur.2023.05.032

Article  PubMed  PubMed Central  Google Scholar 

Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW. Acute kidney injury after cardiac surgery according to Risk/Injury/Failure/Loss/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications. J Crit Care 2013;28:389–96. https://doi.org/10.1016/j.jcrc.2012.12.008

Article  PubMed  Google Scholar 

Yokoyama Y, Chaitman BR, Hardison RM, et al. Association between new electrocardiographic abnormalities after coronary revascularization and five-year cardiac mortality in BARI randomized and registry patients. Am J Cardiol 2000;86:819–24. https://doi.org/10.1016/s0002-9149(00)01099-7

Article  CAS  PubMed  Google Scholar 

Woodman R, Harker L. Bleeding complications associated with cardiopulmonary bypass. Blood 1990;76:1680–97. https://doi.org/10.1182/blood.V76.9.1680.1680

Article  CAS  PubMed 

Comments (0)

No login
gif