Andersson C, Vasan RS (2018) Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol 15:230–240. https://doi.org/10.1038/nrcardio.2017.154

Article  PubMed  Google Scholar 

Bhammar DM, Angadi SS, Gaesser GA (2012) Effects of fractionized and continuous exercise on 24-h ambulatory blood pressure. Med Sci Sports Exerc 44:2270–2276. https://doi.org/10.1249/MSS.0b013e3182663117

Article  PubMed  Google Scholar 

Bhammar DM, Sawyer BJ, Tucker WJ et al (2017) Breaks in sitting time: effects on continuously monitored glucose and blood pressure. Med Sci Sports Exerc 49:2119–2130. https://doi.org/10.1249/MSS.0000000000001315

Article  PubMed  Google Scholar 

Bull FC, Al-Ansari SS, Biddle S et al (2020) World health organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 54:1451–1462. https://doi.org/10.1136/bjsports-2020-102955

Article  PubMed  Google Scholar 

Carter S, Hartman Y, Holder S et al (2017) Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev 45:80–86. https://doi.org/10.1249/JES.0000000000000106

Article  PubMed  Google Scholar 

Chauntry AJ, Bishop NC, Hamer M et al (2023) Frequently interrupting prolonged sitting with light body-weighted resistance activity alters psychobiological responses to acute psychological stress: a randomized crossover trial. Ann Behav Med 57:301–312. https://doi.org/10.1093/abm/kaac055

Article  PubMed  Google Scholar 

Chen C, Lu FC (2004) The guidelines for prevention and control of overweight and obesity in chinese adults. Biomed Environ Sci 17(Suppl):1–36

PubMed  Google Scholar 

Chobanian AV, Bakris GL, Black HR et al (2003) Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 42:1206–1252. https://doi.org/10.1161/01.HYP.0000107251.49515.c2

Article  CAS  PubMed  Google Scholar 

Dempsey PC, Sacre JW, Larsen RN et al (2016) Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes. J Hypertens 34:2376–2382. https://doi.org/10.1097/HJH.0000000000001101

Article  CAS  PubMed  Google Scholar 

Dogra S, Wolf M, Jeffrey MP et al (2019) Disrupting prolonged sitting reduces il-8 and lower leg swell in active young adults. BMC Sports Sci Med Rehabil 11:23. https://doi.org/10.1186/s13102-019-0138-4

Article  PubMed  PubMed Central  Google Scholar 

Finni T, Hu M, Kettunen P et al (2007) Measurement of emg activity with textile electrodes embedded into clothing. Physiol Meas 28:1405–1419. https://doi.org/10.1088/0967-3334/28/11/007

Article  CAS  PubMed  Google Scholar 

Gao Y, Li Q, Yang L et al (2024a) Causal association between sedentary behaviors and health outcomes: a systematic review and meta-analysis of Mendelian randomization studies. Sports Med 54:3051–3067. https://doi.org/10.1007/s40279-024-02090-5

Article  PubMed  Google Scholar 

Gao Y, Li QY, Finni T et al (2024b) Enhanced muscle activity during interrupted sitting improves glycemic control in overweight and obese men. Scand J Med Sci Sports 34:e14628. https://doi.org/10.1111/sms.14628

Article  PubMed  Google Scholar 

Gao Y, Silvennoinen M, Pesola AJ et al (2017) Acute Metabolic Response, Energy Expenditure, and EMG Activity in Sitting and Standing. Med Sci Sports Exerc 49:1927–1934. https://doi.org/10.1249/MSS.0000000000001305

Article  PubMed  Google Scholar 

Horwood A (2019) The biomechanical function of the foot pump in venous return from the lower extremity during the human gait cycle: an expansion of the gait model of the foot pump. Med Hypotheses 129:109220. https://doi.org/10.1016/j.mehy.2019.05.006

Article  PubMed  Google Scholar 

Kataoka H (2013) Clinical characteristics of lower-extremity edema in stage a cardiovascular disease status defined by the acc/aha 2001 chronic heart failure guidelines. Clin Cardiol 36:555–559. https://doi.org/10.1002/clc.22159

Article  PubMed  PubMed Central  Google Scholar 

Koebnick C, Black MH, Wu J et al (2013) High blood pressure in overweight and obese youth: implications for screening. J Clin Hypertens 15:793–805. https://doi.org/10.1111/jch.12199

Article  Google Scholar 

Kowalsky RJ, Jakicic JM, Hergenroeder A et al (2019) Acute cardiometabolic effects of interrupting sitting with resistance exercise breaks. Appl Physiol Nutr Metab 44:1025–1032. https://doi.org/10.1139/apnm-2018-0633

Article  PubMed  Google Scholar 

Lamberg S, Brakenridge CJ, Dunstan DW et al (2025) Electromyography of sedentary behavior: identifying potential for cardiometabolic risk reduction. Med Sci Sports Exerc 57:11–22. https://doi.org/10.1249/mss.0000000000003544

Article  CAS  PubMed  Google Scholar 

Morishima T, Restaino RM, Walsh LK et al (2016) Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol 311:H177-182. https://doi.org/10.1152/ajpheart.00297.2016

Article  PubMed  PubMed Central  Google Scholar 

Nishimura N, Iwase S, Takumi H et al (2021) Gravity-induced lower-leg swelling can be ameliorated by ingestion of α-glucosyl hesperidin beverage. Front Physiol 12:670640. https://doi.org/10.3389/fphys.2021.670640

Article  PubMed  PubMed Central  Google Scholar 

Nobre F, Mion D Jr (2005) Is the area under blood pressure curve the best parameter to evaluate 24-h ambulatory blood pressure monitoring data? Blood Press Monit 10:263–270. https://doi.org/10.1097/01.mbp.0000180669.38161.6e

Article  PubMed  Google Scholar 

Pasley JD, O’Connor PJ (2008) High day-to-day reliability in lower leg volume measured by water displacement. Eur J Appl Physiol 103:393–398. https://doi.org/10.1007/s00421-008-0719-5

Article  PubMed  Google Scholar 

Paterson C, Fryer S, Stone K et al (2022) The effects of acute exposure to prolonged sitting, with and without interruption, on peripheral blood pressure among adults: a systematic review and meta-analysis. Sports Med 52:1369–1383. https://doi.org/10.1007/s40279-021-01614-7

Article  PubMed  Google Scholar 

Pesola A, Brakenridge C, Lamberg S, et al. (2025) Silence of the muscles: wearable electromyography, sitting and type 2 diabetes. Exerc Sport Sci Rev Publish Ahead of Print. https://doi.org/10.1249/JES.0000000000000367

Pesola A, Laukkanen A, Haakana P et al (2014) Muscle inactivity and activity patterns after sedentary-time targeted randomized controlled trial. Med Sci Sports Exerc 46:2122–2133. https://doi.org/10.1249/MSS.0000000000000335

Article  PubMed  Google Scholar 

Pesola AJ, Gao Y, Finni T (2022) Responsiveness of electromyographically assessed skeletal muscle inactivity: methodological exploration and implications for health benefits. Sci Rep 12:20867. https://doi.org/10.1038/s41598-022-25128-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pesola AJ, Laukkanen A, Tikkanen O et al (2015) Muscle inactivity is adversely associated with biomarkers in physically active adults. Med Sci Sports Exerc 47:1188–1196. https://doi.org/10.1249/mss.0000000000000527

Article  CAS  PubMed  Google Scholar 

Pinto AJ, Bergouignan A, Dempsey PC et al (2023) Physiology of sedentary behavior. Physiol Rev 103:2561–2622. https://doi.org/10.1152/physrev.00022.2022

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rabe E, Stücker M, Ottillinger B (2010) Water displacement leg volumetry in clinical studies-a discussion of error sources. BMC Med Res Methodol 10:1–9. https://doi.org/10.1186/1471-2288-10-5

Article  Google Scholar 

Sabag A, Ahmadi MN, Francois ME et al (2024) Timing of moderate to vigorous physical activity, mortality, cardiovascular disease, and microvascular disease in adults with obesity. Diabetes Care 47:890–897. https://doi.org/10.2337/dc23-2448

Article  PubMed  PubMed Central  Google Scholar 

Safar ME (2001) Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens 10:257–261. https://doi.org/10.1097/00041552-200103000-00015