The augmentative role of chitosan and platelet-rich fibrin in reducing epidural fibrosis after laminectomy in rats

Kizilay Z, Kahraman Cetin N, Topcu A, İsmailoğlu Ö, Kurt Ömürlü İ, Aktas S, et al. Effect of etanercept on the formation of epidural fibrosis in an experimental model. Turk Neurosurg. 2018;28:111–7.

PubMed  Google Scholar 

Demirel E, Yildiz K, Çadirci K, Aygün H, Şenocak E, Gündoğdu B. Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® gel and hyaluronic acid. Acta Orthop Traumatol Turc. 2018;52:469–74.

PubMed  PubMed Central  Google Scholar 

Christelis N, Simpson B, Russo M, Stanton-Hicks M, Barolat G, Thomson S, et al. Persistent spinal pain syndrome: a proposal for failed back surgery syndrome and ICD-11. Pain Med. 2021;22:807–18.

PubMed  PubMed Central  Google Scholar 

Wu C, Huang Y, Lee J, Tai T, Wu P, Jou I. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299–306.

PubMed  Google Scholar 

Karatay M, Erdem Y, Koktekir E, Erkoc YS, Caydere M, Bayar MA. The effect of bevacizumab on spinal epidural fibrosis in a postlaminectomy rat model. Turk Neurosurg. 2012;22:753–7.

PubMed  Google Scholar 

Lewik G, Lewik G, Müller LS, von Glinski A, Schulte TL, Lange T. Postoperative epidural fibrosis: challenges and opportunities-a review. Spine Surg Relat Res. 2024;8:133–42.

PubMed  Google Scholar 

Circi E, Atici Y, Baris A, Senel A, Leblebici C, Tekin SB, et al. Is tranexamic acid an effective prevention in the formation of epidural fibrosis? Histological evaluation in the rats. J Korean Neurosurg Soc. 2023;66:503–10.

PubMed  PubMed Central  Google Scholar 

Erdogan B, Is M, Aker F, Emon S, Engin T, Akar E, et al. Preventative effect of diclofenac sodium and/or diltiazem in rats with epidural fibrosis. Bratisl Med J. 2019;120:813–8.

Google Scholar 

Zhang C, Kong X, Liu C, Liang Z, Zhao H, Tong W, et al. ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats. Biochem Biophys Res Commun. 2014;444:395–400.

PubMed  Google Scholar 

Kasimcan MO, Bakar B, Aktaş S, Alhan A, Yilmaz M. Effectiveness of the biophysical barriers on the peridural fibrosis of a postlaminectomy rat model: an experimental research. Injury. 2011;42:778–81.

PubMed  Google Scholar 

Xu D, Zhuang Q, Li Z, Ren Z, Chen X, Li S. A randomized controlled trial on the effects of collagen sponge and topical tranexamic acid in posterior spinal fusion surgeries. J Orthop Surg Res. 2017;12:1–6.

Google Scholar 

He Y, Revel M, Loty B. A quantitative model of post-laminectomy scar formation: effects of a nonsteroidal anti-inflammatory drug. Spine. 1995;20:557–63.

PubMed  Google Scholar 

Bektaşoğlu PK, Somay A, Hazneci J, Borekci A, Gürer B. Cinnamaldehyde has antifibrotic effects on rats with epidural fibrosis. World Neurosurg. 2024;183:e395-400.

PubMed  Google Scholar 

Dayanır H, Dayanır D, Emmez G, Emmez H, Akyol S, İşeri N, et al. Medical ozone treatment on prevention of epidural fibrosis in the rat model. Niger J Clin Pract. 2023;26:1197–203.

PubMed  Google Scholar 

Keskin E, Tönge Ç, Kaya M, Işık E. Evaluation of the effects of berberine in the prevention of epidural fibrosis in rats: an experimental research. Saudi Med J. 2022;43:370.

PubMed  PubMed Central  Google Scholar 

Liu P, Zhang D, Huang G, Xue M, Fang Y, Lu L, et al. Tubastatin. Int J Mol Med. 2022;51:2.

PubMed  PubMed Central  Google Scholar 

Liu Y, Wang R, Han H, Li L. Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway. J Pharm Pharmacol. 2022;74:426–34.

Google Scholar 

Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, et al. Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways. J Cell Mol Med. 2021;25:3272–83.

PubMed  PubMed Central  Google Scholar 

Ribeiro ED, de Santana IHG, Viana MRM, Júnior ESH, Dias JCP, Ferreira-Júnior O, et al. The efficacy of platelet and leukocyte rich fibrin (L-PRF) in the healing process and bone repair in oral and maxillofacial surgeries: a systematic review. Clin Oral Investig. 2024;28:414.

PubMed  Google Scholar 

Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release. 2004;100:5–28.

PubMed  Google Scholar 

Mauricio Sandoval M, Claudia Albornoz R, Sonia Muñoz R, Mirta Fica R, García-Huidobro I, Renato Mertens M, et al. Addition of chitosan may improve the treatment efficacy of triple bandage and compression in the treatment of venous leg ulcers. J Drugs Dermatol. 2011;1:75–9.

Google Scholar 

Li C, Wang H, Liu H, Yin J, Cui L, Chen Z. The prevention effect of poly (L-glutamic acid)/chitosan on spinal epidural fibrosis and peridural adhesion in the post-laminectomy rabbit model. Eur Spine J. 2014;23:2423–31.

PubMed  Google Scholar 

Rodríguez-Vázquez M, Ramos-Zúñiga R. Chitosan-hydroxyapatite scaffold for tissue engineering in experimental lumbar laminectomy and posterolateral spinal fusion in Wistar rats. Asian Spine J. 2019;14:139.

PubMed  PubMed Central  Google Scholar 

Mirjalili F, Mahmoodi M. Controlled release of protein from gelatin/chitosan hydrogel containing platelet-rich fibrin encapsulated in chitosan nanoparticles for accelerated wound healing in an animal model. Int J Biol Macromol. 2023;225:588–604.

PubMed  Google Scholar 

Notario-Pérez F, Martín-Illana A, Cazorla-Luna R, Ruiz-Caro R, Veiga MD. Applications of chitosan in surgical and post-surgical materials. Mar Drugs. 2022;20: 396.

PubMed  PubMed Central  Google Scholar 

Ansarizadeh M, Mashayekhan S, Saadatmand M. Fabrication, modeling and optimization of lyophilized advanced platelet rich fibrin in combination with collagen-chitosan as a guided bone regeneration membrane. Int J Biol Macromol. 2019;125:383–91.

PubMed  Google Scholar 

Dohan Ehrenfest MD, Bielecki T, Jimbo R, Barbe G, Del Corso M, Inchingolo F, et al. Do the fibrin architecture and leukocyte content influence the growth factor release of platelet concentrates? An evidence-based answer comparing a pure platelet-rich plasma (P-PRP) gel and a leukocyte-and platelet-rich fibrin (L-PRF). Curr Pharm Biotechnol. 2012;13:1145–52.

PubMed  Google Scholar 

Winayu I, Ekantari N, Puspita I, Budhijanto W, Nugraheni P. The effect of reduced acetic acid concentration on nano-chitosan formulation as fish preservative. IOP Publishing; 2019. p. 012040.

Google Scholar 

Sangeetha R, Uma K, Chandavarkar V. Comparison of routine decalcification methods with microwave decalcification of bone and teeth. Oral Maxillofac Pathol J. 2013;17:386–91.

Google Scholar 

Borekci A, Kuru Bektasoglu P, Somay A, Hazneci J, Gürer B. Esomeprazole’s antifibrotic effects on rats with epidural fibrosis. Glob Spine J. 2024;15:2611–6.

Google Scholar 

Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res. 1996;6:986–94.

PubMed  Google Scholar 

Gyorfi M, Pillai I, Abd-Elsayed A. Spinal cord stimulation efficacy and erroneous conclusions of the Cochrane Library review of spinal cord stimulation for low back pain by Traeger et al. Brain Sci. 2023;13: 1181.

PubMed  PubMed Central  Google Scholar 

Eldin MMM, Razek NMA. Epidural fibrosis after lumbar disc surgery: prevention and outcome evaluation. Asian Spine J. 2015;9: 370.

Google Scholar 

Lv P, Zhao J, Su W, Liang X, Zhang K. An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1. Eur J Orthop Surg Traumatol. 2015;25:53–8.

Google Scholar 

Song Y, Li Z, He T, Qu M, Jiang L, Li W, et al. M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. Theranostics. 2019;9:2910.

PubMed  PubMed Central  Google Scholar 

Yilmaz A, Karatay M, Yildirim T, Celik H, Sertbas I, Erdem Y, et al. Prevention of epidural fibrosis using ranibizumab in a postlaminectomy rat model. Turk Neurosurg. 2017;27:119–23.

PubMed  Google Scholar 

Ismailoglu O, Kizilay Z, Cetin NK, Topcu A, Berber O. Effect of curcumin on the formation of epidural fibrosis in an experimental laminectomy model in rats. Turk Neurosurg. 2019;29:440–4.

PubMed  Google Scholar 

Liu S, Zhao J, Ruan H, Wang W, Wu T, Cui W, et al. Antibacterial and anti-adhesion effects of the silver nanoparticles-loaded poly (L-lactide) fibrous membrane. Mater Sci Eng, C. 2013;33:1176–82.

Google Scholar 

Ismailoglu O, Albayrak B, Gulsen I, Tanriover G, Demir N. Topical application of tacrolimus prevents epidural fibrosis in a rat postlaminectomy model: histopathological and ultrastructural analysis. Turk Neurosurg. 2011;21:630–3.

PubMed  Google Scholar 

Çetin E, Eren B, Güzey FK, Tufan A, Taş A, Örnek M, et al. Comparison of the effect of bipolar coagulation and fibrillar structured oxidizedcellulose on formation epidural fibrosis in rats. Turk J Med Sci. 2021;51:2206–12.

PubMed  PubMed Central  Google Scholar 

El-Dawy K, Barakat N, Ali H, Sindi IA, Adly HM, Saleh SA. Dexpanthenol improved stem cells against cisplatin-induced kidney injury by inhibition of TNF-α, TGFβ-1, β-catenin, and fibronectin pathways. Saudi J Biol Sci. 2023;30: 103773.

PubMed  PubMed Central  Google Scholar 

Todeschi J, Dannhoff G, Coca AH, Timbolschi DI, Proust F, Lefebvre F, et al. Effect of an intraoperative periradicular application of platelet-rich fibrin (PRF) on residual post-surgical neuropathic pain after disc herniation surgery: study protocol for NeuroPRF, a randomized controlled trial. Trials. 2023;24:418.

PubMed  PubMed Central  Google Scholar 

Anitua E, Pelacho B, Prado R, Aguirre JJ, Sánchez M, Padilla S, et al. Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia. J Controlled Release. 2015;202:31–9.

Google Scholar 

Ding Y, Cui L, Zhao Q, Zhang W, Sun H, Zheng L. Platelet-rich fibrin accelerates skin wound healing in diabetic mice. Ann Plast Surg. 2017;79:e15–9.

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